Competition between T cells maintains clonal dominance during memory inflation induced by MCMV

European Journal of Immunology

Volumn 43, Issue 5, 2013, Pages 1252-1263

  Turula, Holly ^a   Smith, Corinne J ^a   Grey, Finn ^b   Zurbach, Katherine A ^a   Snyder, Christopher M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CD8+ T cells; Immune responses; Memory cells

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELL SELECTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; IMMUNE RESPONSE; MEMORY T LYMPHOCYTE; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; VIROGENESIS;

ADOPTIVE TRANSFER; ANIMALS; CELL TRACKING; CLONE CELLS; HERPESVIRIDAE INFECTIONS; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; MICE; MICE, TRANSGENIC; MUROMEGALOVIRUS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TIME FACTORS;

EID: 84876842649     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242940     Document Type: Article

References (41)

1. Crough, T. and Khanna, R., Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol. Rev. 2009. 22: 76-98.
2. Riddell, S. R., Watanabe, K. S., Goodrich, J. M., Li, C. R., Agha, M. E. and Greenberg, P. D., Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 1992. 257: 238-241.
3. Walter, E. A., Greenberg, P. D., Gilbert, M. J., Finch, R. J., Watanabe, K. S., Thomas, E. D. and Riddell, S. R., Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 1995. 333: 1038-1044.
4. Simon, C. O., Holtappels, R., Tervo, H. M., Bohm, V., Daubner, T., Oehrlein-Karpi, S. A., Kuhnapfel, B. et al., CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation. J. Virol. 2006. 80: 10436-10456.
5. Komatsu, H., Sierro, S., V Cuero, A. and Klenerman, P., Population analysis of antiviral T cell responses using MHC class I-peptide tetramers. Clin. Exp. Immunol. 2003. 134: 9-12.
6. + T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 2005. 202: 673-685.
7. + T cells over time. J. Immunol. 2003. 170: 2022-2029.
8. + T cells in protection against CMV disease. Blood 2003. 101: 2686-2692.
9. + T cell populations after murine cytomegalovirus infection. Eur. J. Immunol. 2005. 35: 1113-1123.
10. Snyder, C. M., Cho, K. S., Bonnett, E. L., van Dommelen, S., Shellam, G. R. and Hill, A. B., Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity 2008. 29: 650-659.
11. + T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus. J. Immunol. 2007. 179: 3203-3213.
12. Iancu, E. M., Corthesy, P., Baumgaertner, P., Devevre, E., Voelter, V., Romero, P., Speiser, D. E. et al., Clonotype selection and composition of human CD8 T cells specific for persistent herpes viruses varies with differentiation but is stable over time. J. Immunol. 2009. 183: 319-331.
13. + T cell populations specific for persistent DNA viruses. J Exp Med 2005. 202:1349-1361.
14. Trautmann, L., Rimbert, M., Echasserieau, K., Saulquin, X., Neveu, B., Dechanet, J., Cerundolo, V. et al., Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses. J. Immunol. 2005. 175: 6123-6132.
15. Torti, N., Walton, S. M., Brocker, T., Rulicke, T. and Oxenius, A., Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. P.LoS. Pathog. 2011. 7: e1002313.
16. Bhattacharya, D., Rossi, D. J., Bryder, D. and Weissman, I. L., Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J. Exp. Med. 2006. 203: 73-85.
17. + tumors or T cells. J. Leukoc. Biol. 2011. 89: 291-300.
18. Muller, A. M., Linderman, J. A., Florek, M., Miklos, D. and Shizuru, J. A., Allogeneic T cells impair engraftment and hematopoiesis after stem cell transplantation. Proc. Natl. Acad. Sci. USA 2010. 107: 14721-14726.
19. van Os, R., Sheridan, T. M., Robinson, S., Drukteinis, D., Ferrara, J. L. and Mauch, P. M., Immunogenicity of Ly5 (CD45)-antigens hampers long-term engraftment following minimal conditioning in a murine bone marrow transplantation model. Stem Cells 2001. 19: 80-87.
20. Xu, H., Exner, B. G., Chilton, P. M., Schanie, C. and Ildstad, S. T., CD45 congenic bone marrow transplantation: evidence for T cell-mediated immunity. Stem Cells 2004. 22: 1039-1048.
21. Waterstrat, A., Liang, Y., Swiderski, C. F., Shelton, B. J. and Van Zant, G., Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood 2010. 115: 408-417.
22. Chen, W., Chatta, G. S., Rubin, W. D., Clark, J. G., Hackman, R. C., Madtes, D. K., Ligitt, D. H. et al., T cells specific for a polymorphic segment of CD45 induce graft-versus-host disease with predominant pulmonary vasculitis. J. Immunol. 1998. 161: 909-918.
23. Taft, R. A., Davisson, M. and Wiles, M. V., Know thy mouse. Trends Genet. 2006. 22: 649-653.
24. Fanning, S. L., Appel, M. Y., Berger, S. A., Korngold, R. and Friedman, T. M., The immunological impact of genetic drift in the B10.BR congenic inbred mouse strain. J. Immunol. 2009. 183: 4261-4272.
25. Alam, S. M., Travers, P. J., Wung, J. L., Nasholds, W., Redpath, S., Jameson, S. C. and Gascoigne, N. R., T-cell-receptor affinity and thymocyte positive selection. Nature 1996. 381: 616-620.
26. Rosette, C., Werlen, G., Daniels, M. A., Holman, P. O., Alam, S. M., Travers, P. J., Gascoigne, N. R. et al., The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 2001. 15: 59-70.
27. Munks, M. W., Cho, K. S., Pinto, A. K., Sierro, S., Klenerman, P. and Hill, A. B., Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection. J. Immunol. 2006. 177: 450-458.
28. Cunningham, P. T., Lloyd, M. L., Harvey, N. L., Williams, E., Hardy, C. M., Redwood, A. J., Lawson, M. A. et al., Promoter control over foreign antigen expression in a murine cytomegalovirus vaccine vector. Vaccine 2010. 29: 141-151.
29. + T cell memory inflation during murine cytomegalovirus infection. J. Immunol. 2009. 183: 3932-3941.
30. Kedl, R. M., Schaefer, B. C., Kappler, J. W. and Marrack, P., T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat. Immunol. 2002. 3: 27-32.
31. Kedl, R. M., Rees, W. A., Hildeman, D. A., Schaefer, B., Mitchell, T., Kappler, J. and Marrack, P., T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 2000. 192: 1105-1113.
32. + T cell response to infection. Immunity 2007. 26: 827-841.
33. + T cell precursor frequency regulates primary and memory responses to infection. Immunity 2008. 28: 859-869.
34. + T cells without selection of higher affinity TCR. Nat. Immunol. 2001. 2: 711-717.
35. Zurita, E., Chagoyen, M., Cantero, M., Alonso, R., Gonzalez-Neira, A., Lopez-Jimenez, A., Lopez-Moreno, J. A. et al., Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res. 2011. 20: 481-489.
36. Zehn, D., Lee, S. Y. and Bevan, M. J., Complete but curtailed T-cell response to very low-affinity antigen. Nature 2009. 458: 211-214.
37. Loewendorf, A. I., Arens, R., Purton, J. F., Surh, C. D. and Benedict, C. A., Dissecting the Requirements for Maintenance of the CMV-Specific Memory T-Cell Pool. Viral Immunol. 2011. 24: 1-5.
38. Holtappels, R., Simon, C. O., Munks, M. W., Thomas, D., Deegen, P., Kuhnapfel, B., Daubner, T. et al., Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination. J. Virol. 2008. 82: 5781-5796.
39. Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K., A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 1991. 350: 423-426.
40. Wagner, M., Jonjic, S., Koszinowski, U. H. and Messerle, M., Systematic excision of vector sequences from the BAC-cloned herpesvirus genome during virus reconstitution. J. Virol. 1999. 73: 7056-7060.
41. Cho, K. S. and Hill, A. B., T cell acquisition of APC membrane can impact interpretation of adoptive transfer experiments using CD45 congenic mouse strains. J. Immunol. Methods 2008. 330: 137-145.