Dichotomy in the anxiolytic versus antidepressant effect of C-terminal truncation of the GluN2A subunit of NMDA receptors

Behavioural Brain Research

Volumn 247, Issue , 2013, Pages 227-231

  Inta, Dragos ^a   Vogt, Miriam A ^a   Pfeiffer, Natascha ^a   Köhr, Georg ^b,c   Gass, Peter ^a  

^a MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Anxiety; Deletion; Depression; GluN2A; Intracellular signalling; NMDA receptors

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANXIETY; ARTICLE; BEHAVIOR CHANGE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DARK LIGHT BOX TEST; EXPERIMENTAL TEST; FORCED SWIMMING TEST; LOCOMOTION; MOOD DISORDER; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; DEPRESSION; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84876814467     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.03.036     Document Type: Article

References (33)

1. Berman R.M., Cappiello A., Anand A., Oren D.A., Heninger G.R., Charney D.S., et al. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47:351-354.
2. Zarate C.A., Singh J.B., Carlson P.J., Brutsche N.E., Ameli R., Luckenbaugh D.A., et al. A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry 2006, 63:856-864.
3. Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry 1994, 51:199-214.
4. Engin E., Treit D., Dickson C.T. Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models. Neuroscience 2009, 161:359-369.
5. Seeburg P.H., Single F., Kuner T., Higuchi M., Sprengel R. Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse. Brain Research 2001, 907:233-243.
6. Monyer H., Burnashev N., Laurie D.J., Sakmann B., Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994, 12:529-540.
7. Cull-Candy S., Brickley S., Farrant M. NMDA receptor subunits: diversity, development and disease. Current Opinion in Neurobiology 2001, 11:327-335.
8. Inta D., Lima-Ojeda J.M., Dormann C., Kohr G., Sprengel R., Gass P. Combined subunit-specific and unspecific inhibition of NMDA receptors triggers distinct cortical c-fos expression patterns. Synapse 2012, 66:752-754.
9. Inta D., Trusel M., Riva M.A., Sprengel R., Gass P. Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications. International Journal of Neuropsychopharmacology 2009, 12:1133-1136.
10. Liu Y., Wong T.P., Aarts M., Rooyakkers A., Liu L., Lai T.W., et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. Journal of Neuroscience 2007, 27:2846-2857.
11. Gass P., Kiessling M., Bading H. Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain. Neuroscience Letters 1993, 162:39-42.
12. Kohr G. NMDA receptor function: subunit composition versus spatial distribution. Cell and Tissue Research 2006, 326:439-446.
13. von Engelhardt J., Doganci B., Jensen V., Hvalby O., Gongrich C., Taylor A., et al. Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron 2008, 60:846-860.
14. Mohn A.R., Gainetdinov R.R., Caron M.G., Koller B.H. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 1999, 98:427-436.
15. Duncan G.E., Inada K., Farrington J.S., Koller B.H., Moy S.S. Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress. Brain Research 2009, 1265:186-195.
16. Niewoehner B., Single F.N., Hvalby O., Jensen V., Meyer zum Alten Borgloh S., Seeburg P.H., et al. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. European Journal of Neuroscience 2007, 25:837-846.
17. Inta D., Monyer H., Sprengel R., Meyer-Lindenberg A., Gass P. Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review. Neuroscience and Biobehavioral Reviews 2010, 34:285-294.
18. Urani A., Chourbaji S., Gass P. Mutant mouse models of depression: candidate genes and current mouse lines. Neuroscience and Biobehavioral Reviews 2005, 29:805-828.
19. Gogas K.R. Glutamate-based therapeutic approaches: NR2B receptor antagonists. Current Opinion in Pharmacology 2006, 6:68-74.
20. Zhang L., Xu T., Wang S., Yu L., Liu D., Zhan R., et al. NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test. Progress in Neuropsychopharmacology and Biological Psychiatry 2013, 40:12-17.
21. Kutsuwada T., Sakimura K., Manabe T., Takayama C., Katakura N., Kushiya E., et al. Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron 1996, 16:333-344.
22. Miyamoto Y., Yamada K., Noda Y., Mori H., Mishina M., Nabeshima T. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. Journal of Neuroscience 2001, 21:750-757.
23. Boyce-Rustay J.M., Holmes A. Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice. Neuropsychopharmacology 2006, 31:2405-2414.
24. Sprengel R., Suchanek B., Amico C., Brusa R., Burnashev N., Rozov A., et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 1998, 92:279-289.
25. Chourbaji S., Zacher C., Sanchis-Segura C., Spanagel R., Gass P. Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice. Behavioural Brain Research 2005, 164:100-106.
26. Chourbaji S., Vogt M.A., Fumagalli F., Sohr R., Frasca A., Brandwein C., et al. AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression. FASEB Journal 2008, 22:3129-3134.
27. Chourbaji S., Hellweg R., Brandis D., Zorner B., Zacher C., Lang U.E., et al. Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain Research. Molecular Brain Research 2004, 121:28-36.
28. Chourbaji S., Urani A., Inta I., Sanchis-Segura C., Brandwein C., Zink M., et al. IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. Neurobiology of Disease 2006, 23:587-594.
29. Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., et al. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. Journal of Neuroscience 2005, 25:6243-6250.
30. Taniguchi S., Nakazawa T., Tanimura A., Kiyama Y., Tezuka T., Watabe A.M., et al. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO Journal 2009, 28:3717-3729.
31. Barkus C., McHugh S.B., Sprengel R., Seeburg P.H., Rawlins J.N., Bannerman D.M. Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. European Journal of Pharmacology 2010, 626:49-56.
32. Tse Y.C., Bagot R.C., Hutter J.A., Wong A.S., Wong T.P. Modulation of synaptic plasticity by stress hormone associates with plastic alteration of synaptic NMDA receptor in the adult hippocampus. PLoS One 2011, 6:e27215.
33. Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 1995, 269:1737-1740.