Identification of GPR39 receptor and ghrelin receptor in thyroid tissues in paediatric patients with immune and non-immune thyroid diseases

Hormone Research in Paediatrics

Volumn 79, Issue 3, 2013, Pages 130-136

  Bossowski, Artur ^a   Czarnocka, Barbara ^c   Harasymczuk, Jerzy ^d   Moniuszko, Anna ^a   Bardadin, Krzysztof ^c   Łyczkowska, Anna ^c   Hanusek, Karolina ^c   Bossowska, Anna ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b Ministry of Internal Affairs Hospital   (Poland)

^c MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Ghrelin receptor family; Graves' disease; Non toxic nodular goiter

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 39; GHRELIN; GHRELIN RECEPTOR; MESSENGER RNA; OBESTATIN; PREPROGHRELIN; UNCLASSIFIED DRUG; HORMONE RECEPTOR; PROTEIN P51; RADIOACTIVE IODINE;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE THYROIDITIS; CHILD; CLINICAL ARTICLE; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; GENE EXPRESSION; GRAVES DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NODULAR GOITER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; THYROID DISEASE; THYROID FUNCTION; TOXIC GOITER; WESTERN BLOTTING; BOY; CONTROLLED STUDY; ECHOGRAPHY; GENE IDENTIFICATION; GENETIC IDENTIFICATION; GIRL; POLYACRYLAMIDE GEL ELECTROPHORESIS; SCINTIGRAPHY; THYROID FOLLICLE CELL;

ADOLESCENT; CHILD; FEMALE; GHRELIN; GOITER; GOITER, NODULAR; GRAVES DISEASE; HUMANS; MALE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GHRELIN; RNA, MESSENGER; THYROID DISEASES; THYROID GLAND; YOUNG ADULT;

EID: 84876811926     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000347218     Document Type: Article

References (30)

1. Knudsen N, Laurberg P, Rasmussen LB, Bulow I, Perrild H, Ovesen L, Jorgensen T: Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005; 90:4019-4024. (Pubitemid 41058166)
2. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382:250-252. (Pubitemid 26251358)
3. Flier JS, Harris M, Hollenberg AN: Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest 2000; 105:859-861.
4. Soares J: Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008; 4:1-16.
5. Riis AL, Hansen TK, Moller N, Weeke J, Jorgensen JO: Hyperthyroidism is associated with suppressed circulating ghrelin levels. J Clin Endocrinol Metab 2003; 88:853-857. (Pubitemid 36207833)
6. El Gawad SS, El Kenawy F, Mousa AA, Omar AA: Plasma levels of resistin and ghrelin before and after treatment in patients with hyperthyroidism. Endocr Pract 2012; 18:376-381.
7. Caminos JE, Seoane LM, Tovar SA, Casanueva FF, Dieguez C: Influence of thyroid status and growth hormone deficiency on ghrelin. Eur J Endocrinol 2002; 147:159-163. (Pubitemid 34814753)
8. Kluge M, Riedl S, Uhr M, Schmidt D, Zhang X, Yassouridisand A, Steiger A: Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma. Eur J Endocrinol 2010; 162:1059-1065.
9. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 11:996-999. (Pubitemid 41611907)
10. Li JB, Asakawa A, Cheng K, Li Y, Chaolu H, Tsai M, Inui A: Biological effects of obestatin. Endocrine 2011; 39:205-211.
11. Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT: Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007; 148:1648-1653. (Pubitemid 46457120)
12. Hassouna R, Zizzari P, Tolle V: The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake. J Neuroendocrinol 2010; 22:793-804.
13. Somogyi V, Gyorffy A, Scalise TJ, Kiss DS, Goszleth G, Bartha T, Frenyo VL, Zsarnovszky A: Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin. Nutr Res Rev 2011; 22:1-23.
14. Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E: Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 2010; 45:107-118.
15. Sawicka B, Bossowski A, Szalecki M, Wysocka J, Koput A, Żelazowska-Rutkowska B, Tobolczyk J, Rogowski F, Łuba M: Relationship between metabolic parameters and thyroid hormones and the level of gastric peptides in children with autoimmune thyroid diseases. J Pediatr Endocrinol Metabol 2010; 23:345-355.
16. El Gawad SS, El-Kenawy FM, Mousa AA, Omar AA: Plasma levels of resistin and ghrelin before and after treatment in patients with hyperthyroidism. Endocr Pract 2011; 8:1-18.
17. Kosowicz J, Baumann-Antczak A, Ruchała M, Gryczyńska M, Gurgul E, Sowiński J: Thyroid hormones affect plasma ghrelin and obestatin levels. Horm Metab Res 2011; 43:121-125.
18. Sosić-Jurjević B, Stevanović D, Milosević V, Sekulić M, Starcević V: Central ghrelin affects pituitary-thyroid axis: histomorphological and hormonal study in rats. Neuroendocrinology 2009; 89:327-336.
19. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, et al: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273:974-977. (Pubitemid 26275178)
20. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD: Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997; 48:23-9. (Pubitemid 27298124)
21. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988-2991. (Pubitemid 34655375)
22. Leite-Moreira AF, Soares JB: Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today 2007; 12:276-288. (Pubitemid 46467484)
23. Morillo-Bernal J, Fernández-Santos JM, De Miguel M, García-Marín R, Gordillo-Martínez F, Díaz-Parrado E, Utrilla JC, Martín-Lacave I: Ghrelin potentiates TSH-induced expression of the thyroid tissue-specific genes thyroglobulin, thyroperoxidase and sodiumiodine symporter, in rat PC-Cl3 cells. Peptides 2011; 32:2333-2339.
24. Verhulst PJ, Lintermans A, Janssen S, Loeckx D, Himmelreich U, Buyse J, Tack J, Depoortere I: GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity. J Neuroendocrinol 2011; 23:490-500.
25. Petersen PS, Jin C, Madsen AN, Rasmussen M, Kuhre R, Egerod KL, Nielsen LB, Schwartz TW, Holst B: Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J 2011; 25:3803-3814.
26. Catalán V, Gómez-Ambrosi J, Rotellar F, Silva C, Gil MJ, Rodríguez A, Cienfuegos JA, Salvador J, Frühbeck G: The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity associated type 2 diabetes mellitus. Clin Endocrinol (Oxf) 2007; 66:598-601. (Pubitemid 46434943)
27. Kim GW, Lin JE, Valentino MA, Colon-Gonzalez F, Waldman SA: Regulation of appetite to treat obesity. Expert Rev Clin Pharmacol 2011; 4:243-259.
28. Carraro G, Albertin G, Aragona F, Forneris M, Casale V, Spinazzi R, Nussdorfer GG: Agedependent decrease in the ghrelin gene expression in the human adrenal cortex: a realtime PCR study. Int J Mol Med 2006; 17:319-321.
29. da Veiga MA, Oliveira Kde J, Curty FH, de Moura CC: Thyroid hormones modulate the endocrine and autocrine/paracrine actions of leptin on thyrotropin secretion. J Endocrinol 2004; 183:243-247. (Pubitemid 40124660)
30. Epelbaum J, Bedjaoui N, Dardennes R, Feng DD, Gardette R, Grouselle D, Loudes C, Simon A, Tolle V, Yang SK, Zizzari P: Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis. Mol Cell Endocrinol 2010; 314:244-247.