Malaria is an uncommon cause of adult sepsis in south-western Uganda

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Auma, Mary A ^a   Siedner, Mark J ^b   Nyehangane, Dan ^c   Nalusaji, Aisha ^c   Nakaye, Martha ^a   Mwanga Amumpaire, Juliet ^a,c   Muhindo, Rose ^a   Wilson, L Anthony ^a   Boum, Yap ^a,c   Moore, Christopher C ^d  

^a MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Uganda)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c EPICENTRE   (France)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Adult; Africa; Malaria; Sepsis; Uganda

Indexed keywords

LACTIC ACID;

ADULT; ARTICLE; AXILLA TEMPERATURE; BLOOD CULTURE; BREATHING RATE; CD4 LYMPHOCYTE COUNT; CONFUSION; FEMALE; GLASGOW COMA SCALE; HEART RATE; HUMAN; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALARIA; MALE; MORTALITY; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; PREVALENCE; RAPID TEST; SEPSIS; SPUTUM SMEAR; SYSTOLIC BLOOD PRESSURE; UGANDA;

ADULT; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALARIA, VIVAX; MALE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PREVALENCE; SEPSIS; UGANDA;

EID: 84876811043     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-146     Document Type: Article

References (28)

1. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin AA, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Lancet 2013 380 2095 2128
2. HIV, malaria parasites, and acute febrile episodes in Ugandan adults: a case-control study. Francesconi P, Fabiani M, Dente MG, Lukwiya M, Okwey R, Ouma J, Ochakachon R, Cian F, Declich S, AIDS 2001 15 2445 2450 10.1097/00002030- 200112070-00013 11740196 (Pubitemid 34014614)
3. Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA, Gilks CF, AIDS 2001 15 899 906 10.1097/00002030-200105040-00010 11399962 (Pubitemid 32424393)
4. Plasmodium infection and its risk factors in eastern Uganda. Pullan RL, Bukirwa H, Staedke SG, Snow RW, Brooker S, Malar J 2010 9 2 10.1186/1475-2875-9- 2 20044942
5. Aggregate evaluable organ dysfunction predicts in-hospital mortality from sepsis in Uganda. Ssekitoleko R, Pinkerton R, Muhindo R, Bhagani S, Moore CC, Am J Trop Med Hyg 2011 85 697 702 10.4269/ajtmh.2011.10-0692 21976575
6. Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A, Lancet 2000 356 1051 1056 10.1016/S0140-6736(00)02727-6 11009139
7. Global malaria mortality between 1980 and 2010: a systematic analysis. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD, Lancet 2012 379 413 431 10.1016/S0140-6736(12) 60034-8 22305225
8. Malaria misdiagnosis in Uganda-implications for policy change. Nankabirwa J, Zurovac D, Njogu JN, Rwakimari JB, Counihan H, Snow RW, Tibenderana JK, Malar J 2009 8 66 10.1186/1475-2875-8-66 19371426
9. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, Saganda K, Shao J, Kitua A, Olomi R, Greenwood BM, Whitty CJ, BMJ 2004 329 1212 10.1136/bmj.38251.658229.55 15542534 (Pubitemid 39551443)
10. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M, Crit Care Med 2006 34 1589 1596 10.1097/01.CCM.0000217961.75225.E9 16625125 (Pubitemid 43810035)
11. Heterogeneous decrease in malaria prevalence in children over a six-year period in south-western Uganda. De Beaudrap P, Nabasumba C, Grandesso F, Turyakira E, Schramm B, Boum Y, Etard JF, Malar J 2011 10 132 10.1186/1475-2875-10-132 21592332
12. Treatment of severe sepsis with artemether-lumefantrine is associated with decreased mortality in Ugandan patients without malaria. Moore CC, Jacob ST, Pinkerton R, Banura P, Meya DB, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM, Am J Trop Med Hyg 2009 80 723 728 19407113
13. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
14. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ, Acta Trop 2012 121 184 195 10.1016/j.actatropica.2011.03.004 21420377
15. Increasing malaria hospital admissions in Uganda between 1999 and 2009. Okiro EA, Bitira D, Mbabazi G, Mpimbaza A, Alegana VA, Talisuna AO, Snow RW, BMC Med 2011 9 37 10.1186/1741-7015-9-37 21486498
16. Clinical manifestations of severe malaria in the highlands of southwestern Uganda. Idro R, Bitarakwate E, Tumwesigire S, John CC, Am J Trop Med Hyg 2005 72 561 567 15891130 (Pubitemid 41278824)
17. Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria. Fogg C, Twesigye R, Batwala V, Piola P, Nabasumba C, Kiguli J, Mutebi F, Hook C, Guillerm M, Moody A, Guthmann JP, Trans R Soc Trop Med Hyg 2008 102 25 31 10.1016/j.trstmh.2007.09.014 18031779 (Pubitemid 350177428)
18. Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis? Swarthout TD, Counihan H, Senga RK, van den Broek I, Malar J 2007 6 58 10.1186/1475-2875-6-58 17506881 (Pubitemid 46902987)
19. The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*. Jacob ST, Banura P, Baeten JM, Moore CC, Meya D, Nakiyingi L, Burke R, Horton CL, Iga B, Wald A, Reynolds SJ, Mayanja-Kizza H, Scheld WM, Crit Care Med 2012 40 2050 2058 10.1097/CCM.0b013e31824e65d7 22564958
20. Severe febrile illness in adult hospital admissions in Tanzania: a prospective study in an area of high malaria transmission. Nadjm B, Mtove G, Amos B, Walker NF, Diefendal H, Reyburn H, Whitty CJ, Trans R Soc Trop Med Hyg 2012 106 688 695 10.1016/j.trstmh.2012.08.006 23022040
21. Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population. Jacob ST, Moore CC, Banura P, Pinkerton R, Meya D, Opendi P, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM, PLoS One 2009 4 7782 10.1371/journal.pone.0007782 19907656
22. Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study. Scott JA, Berkley JA, Mwangi I, Ochola L, Uyoga S, Macharia A, Ndila C, Lowe BS, Mwarumba S, Bauni E, Marsh K, Williams TN, Lancet 2011 378 1316 1323 10.1016/S0140- 6736(11)60888-X 21903251
23. Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study. Crump JA, Ramadhani HO, Morrissey AB, Saganda W, Mwako MS, Yang LY, Chow SC, Njau BN, Mushi GS, Maro VP, Reller LB, Bartlett JA, Clin Infect Dis 2012 55 242 250 10.1093/cid/cis409 22511551
24. Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice. Wallis RS, Pai M, Menzies D, Doherty TM, Walzl G, Perkins MD, Zumla A, Lancet 2010 375 1920 1937 10.1016/S0140-6736(10)60359-5 20488517
25. Leptospirosis among hospitalized febrile patients in northern Tanzania. Biggs HM, Bui DM, Galloway RL, Stoddard RA, Shadomy SV, Morrissey AB, Bartlett JA, Onyango JJ, Maro VP, Kinabo GD, Saganda W, Crump JA, Am J Trop Med Hyg 2011 85 275 281 10.4269/ajtmh.2011.11-0176 21813847
26. Brucellosis among hospitalized febrile patients in Northern Tanzania. Bouley AJ, Biggs HM, Stoddard RA, Morrissey AB, Bartlett JA, Afwamba IA, Maro VP, Kinabo GD, Saganda W, Cleaveland S, Crump JA, Am J Trop Med Hyg 2012 87 1105 1111 10.4269/ajtmh.2012.12-0327 23091197
27. Histoplasmosis among hospitalized febrile patients in northern Tanzania. Lofgren SM, Kirsch EJ, Maro VP, Morrissey AB, Msuya LJ, Kinabo GD, Saganda W, Diefenthal HC, Ramadhani HO, Wheat LJ, Crump JA, Trans R Soc Trop Med Hyg 2012 106 504 507 10.1016/j.trstmh.2012.05.009 22742942
28. Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania. Prabhu M, Nicholson WL, Roche AJ, Kersh GJ, Fitzpatrick KA, Oliver LD, Massung RF, Morrissey AB, Bartlett JA, Onyango JJ, Maro VP, Kinabo GD, Saganda W, Crump JA, Clin Infect Dis 2011 53 8 e15 10.1093/cid/cir411 21810740