Appropriate cone dimensions to achieve negative excision margins after large loop excision of transformation zone in the uterine cervix for cervical intraepithelial neoplasia

Gynecologic and Obstetric Investigation

Volumn 75, Issue 3, 2013, Pages 163-168

  Papoutsis, Dimitrios ^a   Rodolakis, Alexandros ^a   Mesogitis, Spiridon ^a   Sotiropoulou, Maria ^b   Antsaklis, Aris ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b ALEXANDRA HOSPITAL   (Greece)

Author keywords

Cone volume; Conisation depth; Large loop excision of transformation zone conisation

Indexed keywords

ADULT; ARTICLE; CANCER SURGERY; DISEASE SEVERITY; FEMALE; HUMAN; LARGE LOOP EXCISION; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; PARITY; PREDICTOR VARIABLE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CONIZATION;

ADOLESCENT; ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; COLPOSCOPY; CONIZATION; FEMALE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 84876810943     PISSN: 03787346     EISSN: 1423002X     Source Type: Journal    
DOI: 10.1159/000345864     Document Type: Article

References (19)

1. Kitchener HC, Cruickshank ME, Farmery E: The 1993 British Society for Colposcopy and Cervical Pathology/National Coordinating Network United Kingdom Colposcopy Survey. Comparison with 1988 and the response to introduction of guidelines. Br J Obstet Gynaecol 1995; 102: 549-552.
2. Prendiville W, Cullimore J, Norman S: Large loop excision of the transformation zone (LLETZ). A new method of management for women with cervical intraepithelial neoplasia. Br J Obstet Gynaecol 1989; 96: 1054-1060.
3. Kyrgiou M, Koliopoulos G, Martin-Hirsch P, et al: Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and metaanalysis. Lancet 2006; 367: 489-498.
4. Raine-Fenning NJ, Clewes J, Kendall NR, et al: The interobserver reliability and validity of volume calculation from three-dimensional ultrasound datasets in the in vitro setting. Ultrasound Obstet Gynecol 2003; 21: 283-291.
5. Rubio CA, Thomassen P, Soderberg G, et al: Big cones and little cones. Histopathology 1978; 2: 133-143.
6. Papoutsis D, Rodolakis A, Antonakou A, et al: Cervical cone measurements and residual disease in LLETZ conisation for cervical intraepithelial neoplasia. In Vivo 2011; 25: 691-696.
7. Riccabona M, Nelson TR, Pretorius DH: Three-dimensional ultrasound: Accuracy of distance and volume measurements. Ultrasound Obstet Gynecol 1996; 7: 429-434.
8. Ghaem-Maghami S, Sagi S, Majeed G, Soutter WP: Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: A meta-analysis. Lancet Oncol 2007; 8: 985-993.
9. Cho HY, Kim YB, Hong No J, et al: Endocervical margin involvement as an important risk factor for abnormal cytology after LLETZ. Int J Gynecol Pathol 2012; 31: 377-381.
10. Ang C, Mukhopadhyay A, Burnley C, et al: Histological recurrence and depth of loop treatment of the cervix in women of reproductive age: incomplete excision versus adverse pregnancy outcome. BJOG 2011; 118: 685-692.
11. Anderson MC, Hartley RB: Cervical crypt involvement by intraepithelial neoplasia. Obstet Gynecol 1980; 55: 546-550.
12. Department of Health: Colposcopy and Programme Management. Guidelines for the NHS Cervical Screening Programme. NHSCSP Publication No. 20. Sheffield, NHSCSP, 2010.
13. Jordan J, Martin-Hirsch P, Arbyn M, et al: European guidelines for clinical management of abnormal cervical cytology. Part 2. Cytopathology 2009; 20: 5-16.
14. Arbyn M, Kyrgiou M, Simoens C, et al: Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ 2008; 337: 1284-1295.
15. Leiman G, Harrison NA, Rubin A: Pregnancy following conization of the cervix: complications related to cone size. Am J Obstet Gynecol 1980; 136: 14-18.
16. Noehr B, Jensen A, Frederiksen K, et al: Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery. Obstet Gynecol 2009; 114: 1232-1238.
17. Founta C, Arbyn M, Valasoulis G, et al: Proportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasia. BJOG 2010; 117: 1468-1474.
18. Papoutsis D, Rodolakis A, Mesogitis S, et al: Regeneration of uterine cervix at 6 months after large loop excision of the transformation zone for cervical intraepithelial neoplasia. BJOG 2012; 119: 678-684.
19. Boonlikit S, Yanaranop M: Thermal artifact after three techniques of loop excision of the transformation zone: A comparative study. Gynecol Obstet Invest 2012; 73: 230-235.