Overexpression of IL-6 by gene transfer stimulates IL-8-mediated invasiveness of KYSE170 esophageal carcinoma cells

Anticancer Research

Volumn 33, Issue 4, 2013, Pages 1483-1489

  Okamura, Shinichi ^a   Fujiwara, Hitoshi ^a   Yoneda, Masayuki ^a   Furutani, Akinobu ^a   Todo, Momoko ^a   Ikai, Atsushi ^a   Tada, Hiroyuki ^a   Okamura, Hiroko ^a   Umehara, Seiji ^a   Shiozaki, Atsushi ^a   Kubota, Takeshi ^a   Komatsu, Shuhei ^a   Ichikawa, Daisuke ^a   Okamoto, Kazuma ^a   Ochiai, Toshiya ^a   Otsuji, Eigo ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Esophageal carcinoma; IL 6; IL 8; Invasiveness; KYSE170 cells

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; PLASMID VECTOR; SCATTER FACTOR; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL ACTIVITY; CELL INVASION; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULATION;

BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL NEOPLASMS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTE GROWTH FACTOR; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; NEOPLASM INVASIVENESS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876774075     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med 349: 2241-2252, 2003. (Pubitemid 37485141)
2. Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J and Simes J: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol 8: 226-234, 2007. (Pubitemid 46291702)
3. Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K and Fukuda H: A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol 19: 68-74, 2012.
4. Guo Y, Xu F, Lu T, Duan Z and Zhang Z: Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 38: 904-910, 2012.
5. Wang LS, Chow KC and Wu CW: Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by N-sodium butyrate. Br J Cancer 80: 1617-1622, 1999.
6. Oka M, Yamamoto K, Takahashi M, Hakozaki M, Abe T, Iizuka N, Hazama S, Hirazawa K, Hayashi H, Tangoku A, Hirose K, Ishihara T and Suzuki T: Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma. Cancer Res 56: 2776-2780, 1996. (Pubitemid 26175737)
7. Deans DA, Wigmore SJ, Gilmour H, Paterson-Brown S, Ross JA and Fearon KC: Elevated tumour interleukin-1beta is associated with systemic inflammation: A marker of reduced survival in gastro-oesophageal cancer. Br J Cancer 95: 1568-1575, 2006. (Pubitemid 44863361)
8. Leu CM, Wong FH, Chang C, Huang SF and Hu CP: Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene 22: 7809-7818, 2003. (Pubitemid 37485540)
9. Fujiwara H, Suchi K, Okamura S, Okamura H, Umehara S, Todo M, Shiozaki A, Kubota T, Ichikawa D, Okamoto K, Ochiai T, Kokuba Y, Sonoyama T and Otsuji E: Elevated serum CRP levels after induction chemoradiotherapy reflect poor treatment response in association with IL-6 in serum and local tumor site in patients with advanced esophageal cancer. J Surg Oncol 103: 62-68, 2011.
10. Suchi K, Fujiwara H, Okamura S, Okamura H, Umehara S, Todo M, Furutani A, Yoneda M, Shiozaki A, Kubota T, Ichikawa D, Okamoto K and Otsuji E: Overexpression of interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells. Anticancer Res 31: 67-75, 2011.
11. Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet 357: 539-545, 2001. (Pubitemid 32173595)
12. Abdel-Latif MM, O'Riordan JM, Ravi N, Kelleher D and Reynolds JV: Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy. Dis Esophagus 18: 246-252, 2005. (Pubitemid 43904793)
13. Kanazawa T, Nishino H, Hasegawa M, Ohta Y, Iino Y, Ichimura K and Noda Y: Interleukin-6 directly influences proliferation and invasiveness potential of head and neck cancer cells. Eur Arch Otorhinolaryngol 264: 815-821, 2007. (Pubitemid 46817497)
14. Badache A and Hynes NE: Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. Cancer Res 61: 383-391, 2001. (Pubitemid 32095742)
15. Oh JW, Katz A, Harroch S, Eisenbach L, Revel M and Chebath J: Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: Growth inhibition and differentiation of B16-F10.9 tumor cells. Oncogene 15: 569-577, 1997. (Pubitemid 27384734)
16. Studebaker AW, Storci G, Werbeck JL, Sansone P, Sasser AK, Tavolari S, Huang T, Chan MW, Marini FC, Rosol TJ, Bonafé M and Hall BM: Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res 68: 9087-9095, 2008.
17. Ren Y, Cao B, Law S, Xie Y, Lee PY, Cheung L, Chen Y, Huang X, Chan HM, Zhao P, Luk J, Vande Woude G and Wong J: Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res 11: 6190-6197, 2005. (Pubitemid 41262947)
18. Deans DA, Wigmore SJ, Gilmour H, Paterson-Brown S, Ross JA and Fearon KC: Elevated tumour interleukin-1beta is associated with systemic inflammation: A marker of reduced survival in gastro-oesophageal cancer. Br J Cancer 95: 1568-1575, 2006. (Pubitemid 44863361)
19. Waugh DJ and Wilson C: The interleukin-8 pathway in cancer. Clin Cancer Res 14: 6735-6741, 2008.
20. Benoy IH, Salgado R, Van Dam P, Geboers K, Van Marck E, Scharpé S, Vermeulen PB and Dirix LY: Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 10: 7157-7162, 2004. (Pubitemid 39487700)
21. Gokhale AS, Haddad RI, Cavacini LA, Wirth L, Weeks L, Hallar M, Faucher J and Posner MR: Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck. Oral Oncol 41: 70-76, 2005. (Pubitemid 39647122)
22. Kaminska J, Nowacki MP, Kowalska M, Rysinska A, Chwalinski M, Fuksiewicz M, Michalski W and Chechlinska M: Clinical significance of serum cytokine measurements in untreated colorectal cancer patients: Soluble tumor necrosis factor receptor type I - An independent prognostic factor. Tumour Biol 26: 186-194, 2005. (Pubitemid 41379744)
23. Ren Y, Poon RT, Tsui HT, Chen WH, Li Z, Lau C, Yu WC and Fan ST: Interleukin-8 serum levels in patients with hepatocellular carcinoma: Correlations with clinicopathological features and prognosis. Clin Cancer Res 9: 5996-6001, 2003. (Pubitemid 38018086)
24. Krzystek-Korpacka M, Matusiewicz M, Diakowska D, Grabowski K, Blachut K, Konieczny D, Kustrzeba-Wojcicka I, Terlecki G and Banas T: Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas - Implication for clinical evaluation of cancer patient. Cytokine 41: 232-239, 2008.
25. Yao C, Lin Y, Chua MS, Ye CS, Bi J, Li W, Zhu YF and Wang SM: Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells. Int J Cancer 121: 1949-1957, 2007. (Pubitemid 47463157)
26. Kuwada Y, Sasaki T, Morinaka K, Kitadai Y, Mukaida N and Chayama K: Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. Int J Oncol 22: 765-771, 2003.
27. Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, Oberyszyn TM and Hall BM: Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28: 2940-2947, 2009.
28. Lederle W, Depner S, Schnur S, Obermueller E, Catone N, Just A, Fusenig NE and Mueller MM: IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer 128: 2803-2814, 2011.