Clinical safety, pharmacokinetics, and pharmacodynamics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 in healthy volunteers and elderly adults

Clinical Pharmacology in Drug Development

Volumn 2, Issue 2, 2013, Pages 133-151

  Liu, Wei ^a   Katz, David A ^a   Locke, Charles ^a   Daszkowski, Dan ^a   Wang, Yi ^a   Rieser, Matthew J ^a   Awni, Walid ^a   Marek, Gerard J ^a   Dutta, Sandeep ^a  

^a ABBVIE INC   (United States)

Author keywords

Clinical trial; Enzyme inhibitor; Hydroxysteroid dehydrogenase; Pharmacodynamics; Pharmacokinetics

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ABT 384; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANDROGEN; ASPARTATE AMINOTRANSFERASE; CORTICOTROPIN; DRUG METABOLITE; ENZYME INHIBITOR; ESTRADIOL; GAMMA GLUTAMYLTRANSFERASE; HYDROCORTISONE; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ALZHEIMER DISEASE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTACT DERMATITIS; CONTROLLED STUDY; COUGHING; DERMATITIS; DIABETES MELLITUS; DIARRHEA; DIZZINESS; DOSAGE SCHEDULE COMPARISON; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG FATALITY; DRUG HALF LIFE; DRUG INDICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; DYSPEPSIA; FEMALE; FOOD DRUG INTERACTION; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEADACHE; HEART ARRHYTHMIA; HORMONE SYNTHESIS; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE URINE LEVEL; HYPERTENSION; IN VITRO STUDY; INSOMNIA; LETHARGY; LYMPHOCYTE; MALE; METABOLIC SYNDROME X; MOOD DISORDER; MUSCULOSKELETAL PAIN; NORMAL HUMAN; NOSE OBSTRUCTION; OROPHARYNX PAIN; OTALGIA; PHARMACODYNAMICS; PHARMACOLOGICAL PARAMETERS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QRS COMPLEX; QT PROLONGATION; RASH; SINGLE DRUG DOSE; SOMNOLENCE; TACHYCARDIA; THERAPEUTIC INDEX; THORAX PAIN; TOOTH PAIN; UNSPECIFIED SIDE EFFECT; VIRUS INFECTION;

EID: 84876770735     PISSN: 2160763X     EISSN: 21607648     Source Type: Journal    
DOI: 10.1002/cpdd.5     Document Type: Article

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