Cleaved caspase-3 expression in hypothalamic magnocellular neurons may affect vasopressin secretion during experimental polymicrobial sepsis

Journal of Neuroimmunology

Volumn 258, Issue 1-2, 2013, Pages 10-16

  Oliveira Pelegrin, Gabriela Ravanelli ^a   Basso, Paulo José ^a   Soares, Aline Souza ^a   Martinez, Mariana Rossin ^a   Riester, Karin Dorota ^a,b   Rocha, Maria José Alves ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cecal ligation and puncture; Cytokines; Nitric oxide; Paraventricular nucleus; Supraoptic nucleus

Indexed keywords

CASPASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRATE; TUMOR NECROSIS FACTOR ALPHA; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL INFECTION; GIANT CELL; HORMONE DEFICIENCY; HORMONE RELEASE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SEPSIS; SUPRAOPTIC NUCLEUS; UPREGULATION; VASOPRESSIN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; NITRATES; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEPSIS; VASOPRESSINS;

EID: 84876735701     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2013.02.007     Document Type: Article

References (36)

1. Alexander J.J., Jacob A., Cunningham P., Hensley L., Quigg R.J. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem. Int. 2008, 52:447-456.
2. Bantel H., Schulze-Osthoff K. Cell death in sepsis: a matter of how, when, and where. Crit. Care 2009, 13:173.
3. Berg R.M., Moller K., Bailey D.M. Neuro-oxidative-nitrosative stress in sepsis. J. Cereb. Blood Flow Metab. 2011, 31:1532-1544.
4. Bone R.C., Sprung C.L., Sibbald W.J. Definitions for sepsis and organ failure. Crit. Care Med. 1992, 20:724-726.
5. Bruhn F.H., Correa P.B., Oliveira-Pelegrin G.R., Rocha M.J. Blocking systemic nitric oxide production alters neuronal activation in brain structures involved in cardiovascular regulation during polymicrobial sepsis. Neurosci. Lett. 2009, 453:141-146.
6. Bustin S.A., Benes V., Garson J.A., Hellemans J., Huggett J., Kubista M., Mueller R., Nolan T., Pfaffl M.W., Shipley G.L., Vandesompele J., Wittwer C.T. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 2009, 55(4):611-622.
7. Correa P.B., Pancoto J.A., de Oliveira-Pelegrin G.R., Carnio E.C., Rocha M.J. Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis. J. Neuroimmunol. 2007, 183:17-25.
8. Erusalimsky J.D., Moncada S. Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler. Thromb. Vasc. Biol. 2007, 27:2524-2531.
9. Kovacs K.J. Neurohypophyseal hormones in the integration of physiological responses to immune challenges. Prog. Brain Res. 2002, 139:127-146.
10. Landry D.W., Levin H.R., Gallant E.M., Ashton R.C., Seo S., D'Alessandro D., Oz M.C., Oliver J.A. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 1997, 95:1122-1125.
11. Mander P., Brown G.C. Nitric oxide, hypoxia and brain inflammation. Biochem. Soc. Trans. 2004, 32:1068-1069.
12. Mander P., Brown G.C. Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration. J. Neuroinflammation 2005, 2:20.
13. Mastorakos G., Weber J.S., Magiakou M.A., Gunn H., Chrousos G.P. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J. Clin. Endocrinol. Metab. 1994, 79:934-939.
14. McCann S.M., Kimura M., Karanth S., Yu W.H., Mastronardi C.A., Rettori V. The mechanism of action of cytokines to control the release of hypothalamic and pituitary hormones in infection. Ann. N. Y. Acad. Sci. 2000, 917:4-18.
15. Mignotte B., Vayssiere J.L. Mitochondria and apoptosis. Eur. J. Biochem. 1998, 252:1-15.
16. Nemzek J.A., Xiao H.Y., Minard A.E., Bolgos G.L., Remick D.G. Humane endpoints in shock research. Shock 2004, 21:17-25.
17. Oliveira-Pelegrin G.R., Ravanelli M.I., Branco L.G., Rocha M.J. Thermoregulation and vasopressin secretion during polymicrobial sepsis. Neuroimmunomodulation 2009, 16:45-53.
18. Oliveira-Pelegrin G.R., Aguila F.A., Basso P.J., Rocha M.J. Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis. Peptides 2010, 31:1847-1852.
19. Oliveira-Pelegrin G.R., de Azevedo S.V., Yao S.T., Murphy D., Rocha M.J. Central NOS inhibition differentially affects vasopressin gene expression in hypothalamic nuclei in septic rats. J. Neuroimmunol. 2010, 227:80-86.
20. Palkovits M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res. 1973, 59:449-450.
21. Pancoto J.A., Correa P.B., Oliveira-Pelegrin G.R., Rocha M.J. Autonomic dysfunction in experimental sepsis induced by cecal ligation and puncture. Auton. Neurosci. 2008, 138:57-63.
22. Pfaffl M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002, 30:e36.
23. Porter A.G., Janicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999, 6:99-104.
24. Rivest S., Lacroix S., Vallieres L., Nadeau S., Zhang J., Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc. Soc. Exp. Biol. Med. 2000, 223:22-38.
25. Russell J.A. Vasopressin in vasodilatory and septic shock. Curr. Opin. Crit. Care 2007, 13:383-391.
26. Schwerk C., Schulze-Osthoff K. Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem. Pharmacol. 2003, 66:1453-1458.
27. Semmler A., Okulla T., Sastre M., Dumitrescu-Ozimek L., Heneka M.T. Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J. Chem. Neuroanat. 2005, 30:144-157.
28. Sharshar T., Blanchard A., Paillard M., Raphael J.C., Gajdos P., Annane D. Circulating vasopressin levels in septic shock. Crit. Care Med. 2003, 31:1752-1758.
29. Sharshar T., Gray F., Lorin de la Grandmaison G., Hopkinson N.S., Ross E., Dorandeu A., Orlikowski D., Raphael J.C., Gajdos P., Annane D. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003, 362:1799-1805.
30. Sharshar T., Annane D., de la Grandmaison G.L., Brouland J.P., Hopkinson N.S., Francoise G. The neuropathology of septic shock. Brain Pathol. 2004, 14:21-33.
31. Siami S., Bailly-Salin J., Polito A., Porcher R., Blanchard A., Haymann J.P., Laborde K., Maxime V., Boucly C., Carlier R., Annane D., Sharshar T. Osmoregulation of vasopressin secretion is altered in the postacute phase of septic shock. Crit. Care Med. 2010, 38:1962-1969.
32. Swanson L.W. Brain Maps: Structure of the Rat Brain 1998, Elsevier Science, Amsterdam.
33. Villapol S., Acarin L., Faiz M., Castellano B., Gonzalez B. Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain. Neuroscience 2008, 153:108-119.
34. Vincent J.L., Korkut H.A. Defining sepsis. Clin. Chest Med. 2008, 29:585-590. (vii).
35. Wong M.L., Bongiorno P.B., Al-Shekhlee A., Esposito A., Khatri P., Licinio J. IL-1 beta, IL-1 receptor type I and iNOS gene expression in rat brain vasculature and perivascular areas. Neuroreport 1996, 7:2445-2448.
36. Wong M.L., Bongiorno P.B., Rettori V., McCann S.M., Licinio J. Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:227-232.