Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities

Anti-Cancer Agents in Medicinal Chemistry

Volumn 13, Issue 4, 2013, Pages 546-554

  Golubovskaya, Vita M ^a,b   Ho, Baotran ^a   Zheng, Min ^c   Magis, Andrew ^d   Ostrov, David ^d   Cance, William G ^a,b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

ATP; Cancer; Enzyme activity; FAK; Focal adhesion kinase; Kinase; Therapy

Indexed keywords

2 [5 CHLORO 2 (2 METHOXY 4 MORPHOLINOANILINO) 4 PYRIMIDINYLAMINO] N METHYLBENZAMIDE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; MITOXANTRONE; PF 562271; PF 573228; PND 1186; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CELL VIABILITY; COLON CANCER; COMPUTER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; ONCOGENE SRC; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BINDING SITES; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MITOXANTRONE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84876720453     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520611313040003     Document Type: Article

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