Multi-allelic haplotype association identifies novel information different from single-SNP analysis: A new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI

Gene

Volumn 521, Issue 1, 2013, Pages 78-81

  Shen, Gong Qing ^a   Girelli, Domenico ^b   Li, Lin ^a   Olivieri, Oliviero ^b   Martinelli, Nicola ^b   Chen, Qiuyun ^a   Topol, Eric J ^c,e   Wang, Qing K ^a,d,e  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF VERONA   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SCRIPPS CLINIC   (United States)

^e HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Association study; Haplotype; LRP8; SNPs

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 8; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CORONARY ARTERY DISEASE; FAMILY HISTORY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HEART INFARCTION; HEART PROTECTION; HUMAN; ITALY; POPULATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; ITALY; LDL-RECEPTOR RELATED PROTEINS; MYOCARDIAL INFARCTION; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84876717752     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.03.022     Document Type: Article

References (11)

1. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265.
2. Guttmacher A.E., Collins F.S., Carmona R.H. The family history-more important than ever. N. Engl. J. Med. 2004, 351(22):2333-2336.
3. Huo Y., et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat. Med. 2003, 9(1):61-67.
4. Martinelli N., et al. Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study. BMC Med. Genet. 2009, 10:41.
5. Quinn K.L., et al. Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation. Arterioscler. Thromb. Vasc. Biol. 2011, 31(9):2070-2079.
6. Robertson J.O., Li W., Silverstein R.L., Topol E.J., Smith J.D. Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis. Thromb. Res. 2009, 123(4):644-652.
7. Roger V.L., et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012, 125(1):e2-e220.
8. Shah S.H. Gene polymorphisms and susceptibility to coronary artery disease. Pediatr. Blood Cancer 2007, 48(7):738-741.
9. Shen G.Q., et al. An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. Am. J. Hum. Genet. 2007, 81(4):780-791.
10. Shen G.Q., Abdullah K.G., Wang Q.K. The TaqMan method for SNP genotyping. Methods Mol. Biol. 2009, 578:293-306.
11. Wang Q., et al. Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am. J. Hum. Genet. 2004, 74(2):262-271.