Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis

Thrombosis Research

Volumn 123, Issue 4, 2009, Pages 644-652

  Robertson, Jason O ^a,b   Li, Wei ^a   Silverstein, Roy L ^a,b   Topol, Eric J ^c   Smith, Jonathan D ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

ApoER2; Hemostasis; LRP8; Platelet; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; APOLIPOPROTEIN E3; CHOLESTEROL; FERRIC CHLORIDE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 8; NITRIC OXIDE; THROMBIN; UNCLASSIFIED DRUG;

AGGREGOMETRY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BLEEDING TIME; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FLOW CYTOMETRY; GENOTYPE; HEMOSTASIS; INJURY; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 8 DEFICIENCY; MALE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TAIL BLEEDING ASSAY; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOSIS;

ANIMALS; APOLIPOPROTEIN E3; BLOOD PLATELETS; FERRIC COMPOUNDS; HUMANS; MICE; MICE, KNOCKOUT; NITRIC OXIDE; PLATELET ACTIVATION; RECEPTORS, LIPOPROTEIN; THROMBOSIS;

EID: 58649099165     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.07.003     Document Type: Article

References (27)

1. Marenberg M.E., Risch N., Berkman L.F., Floderus B., and de Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330 (1994) 1041-1046
2. Wang Q., Rao S., Shen G.Q., Li L., Moliterno D.J., Newby L.K., et al. Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet 74 (2004) 262-271
3. Shen G.Q., Li L., Girelli D., Seidelmann S.B., Rao S., Fan C., et al. An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. Am J Hum Genet 81 (2007) 780-791
4. Brown M.S., and Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232 (1986) 34-47
5. Riddell D.R., Vinogradov D.V., Stannard A.K., Chadwick N., and Owen J.S. Identification and characterization of LRP8 (apoER2) in human blood platelets. J Lipid Res 40 (1999) 1925-1930
6. Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J., Stockinger W., Nimpf J., et al. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97 (1999) 689-701
7. Riddell D.R., Sun X.M., Stannard A.K., Soutar A.K., and Owen J.S. Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J Lipid Res 42 (2001) 998-1002
8. Andersen O.M., Yeung C.H., Vorum H., Wellner M., Andreassen T.K., Erdmann B., et al. Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem 278 (2003) 23989-23995
9. Andrade N., Komnenovic V., Blake S.M., Jossin Y., Howell B., Goffinet A., et al. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci U S A 104 (2007) 8508-8513
10. Korporaal S.J., Relou I.A., van Eck M., Strasser V., Bezemer M., Gorter G., et al. Binding of low density lipoprotein to platelet apolipoprotein E receptor 2′ results in phosphorylation of p38MAPK. J Biol Chem 279 (2004) 52526-52534
11. Li Y., Lu W., Marzolo M.P., and Bu G. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J Biol Chem 276 (2001) 18000-18006
12. Sun X.M., and Soutar A.K. Expression in vitro of alternatively spliced variants of the messenger RNA for human apolipoprotein E receptor-2 identified in human tissues by ribonuclease protection assays. Eur J Biochem 262 (1999) 230-239
13. Pennings M.T., Derksen R.H., Urbanus R.T., Tekelenburg W.L., Hemrika W., and de Groot P.G. Platelets express three different splice variants of ApoER2 that are all involved in signaling. J Thromb Haemost 5 (2007) 1538-1544
14. Riddell D.R., Graham A., and Owen J.S. Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease. J Biol Chem 272 (1997) 89-95
15. Zhu K., Brubaker G., and Smith J.D. Large disk intermediate precedes formation of apolipoprotein A-I-dimyristoylphosphatidylcholine small disks. Biochemistry 46 (2007) 6299-6307
16. Innerarity T.L., Pitas R.E., and Mahley R.W. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem 254 (1979) 4186-4190
17. Jurk K., and Kehrel B.E. Platelets: physiology and biochemistry. Semin Thromb Hemost 31 (2005) 381-392
18. Bu G., Williams S., Strickland D.K., and Schwartz A.L. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci U S A 89 (1992) 7427-7431
19. Cabello-Verrugio C., and Brandan E. A Novel Modulatory Mechanism of Transforming Growth Factor-beta Signaling through Decorin and LRP-1. J Biol Chem 282 (2007) 18842-18850
20. Loukinova E., Ranganathan S., Kuznetsov S., Gorlatova N., Migliorini M.M., Loukinov D., et al. Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. J Biol Chem 277 (2002) 15499-15506
21. Mikhailenko I., Kounnas M.Z., and Strickland D.K. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin. A process facilitated by cell-surface proteoglycans. J Biol Chem 270 (1995) 9543-9549
22. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240 (1988) 622-630
23. Higashihara M., Kinoshita M., Teramoto T., Kume S., and Kurokawa K. The role of apoE in inhibitory effects of apoE-rich HDL on platelet function. FEBS Lett 282 (1991) 82-86
24. Stuart M.J., Gerrard J.M., and White J.G. Effect of cholesterol on production of thromboxane b2 by platelets in vitro. N Engl J Med 302 (1980) 6-10
25. Tandon N., Harmon J.T., Rodbard D., and Jamieson G.A. Thrombin receptors define responsiveness of cholesterol-modified platelets. J Biol Chem 258 (1983) 11840-11845
26. Brass L.F. Thrombin and platelet activation. Chest 124 (2003) 18S-25S
27. Rosenfeld M.E., Butler S., Ord V.A., Lipton B.A., Dyer C.A., Curtiss L.K., et al. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. Arterioscler Thromb 13 (1993) 1382-1389