Controlling intrathoracic hemorrhage on ECMO: Help from Factor VIIa and Virchow

Perfusion (United Kingdom)

Volumn 28, Issue 3, 2013, Pages 201-206

  Rigby, M R ^a   Kamat, P ^b   Vats, A ^b   Heard, M ^b  

^a INDIANA UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

activated factor VIIa; aminocaproic acid.; chest tube; extracorporeal membrane oxygenation (ECMO); hemorrhage; hemothorax; pneumothorax

Indexed keywords

AMINOCAPROIC ACID; ANTIBIOTIC AGENT; BLOOD CLOTTING FACTOR 7A; FIBRINOGEN; METHYLPREDNISOLONE SODIUM SUCCINATE; NEUTROPHIL CYTOPLASMIC ANTIBODY; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ARTICLE; BRONCHOSCOPY; CASE REPORT; CHEST TUBE; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DAY HOSPITAL; EXTRACORPOREAL OXYGENATION; HEMATOTHORAX; HIGH FREQUENCY OSCILLATION; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPOXEMIA; INTENSIVE CARE UNIT; INTERNATIONAL NORMALIZED RATIO; LOWER RESPIRATORY TRACT INFECTION; LUNG HEMORRHAGE; LUNG VENTILATION; MALE; OXYGEN DESATURATION; PLEURA EFFUSION; POSITIVE END EXPIRATORY PRESSURE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RESPIRATORY DISTRESS; RESPIRATORY FAILURE; SCHOOL CHILD; TENSION PNEUMOTHORAX; THORACOCENTESIS; THORAX RADIOGRAPHY; THROMBOCYTE TRANSFUSION; UPPER RESPIRATORY TRACT INFECTION;

AMINOCAPROIC ACIDS; AUTOIMMUNE DISEASES; CHILD; DECOMPRESSION, SURGICAL; EXTRACORPOREAL MEMBRANE OXYGENATION; FACTOR VIIA; HEMORRHAGE; HUMANS; MALE; PNEUMONIA; PNEUMOTHORAX; RESPIRATORY INSUFFICIENCY; VASCULITIS;

EID: 84876713217     PISSN: 02676591     EISSN: 1477111X     Source Type: Journal    
DOI: 10.1177/0267659112469549     Document Type: Article

References (19)

1. Zwischenberger JB, Bowers RM, Pickens GJ.. Tension pneumothorax during extracorporeal membrane oxygenation. Ann Thorac Surg. 1989 ; 47: 868-871 (Pubitemid 19182528)
2. Horwitz JR, Cofer BR, Warner BW, Cheu HW, Lally KP.. A multicenter trial of 6-aminocaproic acid (Amicar) in the prevention of bleeding in infants on ECMO. J Pediatr Surg. 1998 ; 33: 1610-1613 (Pubitemid 28530409)
3. Downard CD, Betit P, Chang RWsss, Garza JJ, Arnold JH, Wilson JM.. Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review. J Pediatr Surg. 2003 ; 38: 1212-1216 (Pubitemid 37048044)
4. Verrijckt A, Proulx F, Morneau S, Vobecky S.. Activated recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg. 2004 ; 127: 1812-1813 (Pubitemid 38725466)
5. DiDomenico RJ, Massad MG, Kpodonu J, Navarro RA, Geha AS.. Use of recombinant activated factor VII for bleeding following operations requiring cardiopulmonary bypass. Chest. 2005 ; 127: 1828-1835 (Pubitemid 46218814)
6. Dominguez TE, Mitchell M, Friess SH, et al. Use of recombinant factor VIIa for refractory hemorrhage during extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2005 ; 6: 348-351 (Pubitemid 40724289)
7. Levi M, Peters M, Buller HR.. Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review. Crit Care Med. 2005 ; 33: 883-890
8. Wittenstein B, Ng C, Ravn H, Goldman A.. Recombinant factor VII for severe bleeding during extracorporeal membrane oxygenation following open heart surgery. Pediatr Crit Care Med. 2005 ; 6: 473-476 (Pubitemid 40980831)
9. Davis MC, Andersen NE, Johansson P, Andersen LW.. Use of thromboelastograph and factor VII for the treatment of postoperative bleeding in a pediatric patient on ECMO after cardiac surgery. J Extra Corpor Technol. 2006 ; 38: 165-167 (Pubitemid 351506603)
10. Veldman A, Neuhaeuser C, Akintuerk H, et al. rFVIIa in the treatment of persistent hemorrhage in pediatric patients on ECMO following surgery for congenital heart disease. Paediatr Anaesth. 2007 ; 17: 1176-1181 (Pubitemid 350059105)
11. Preston TJ, Olshove VF, Ayad O, Nicol KK, Riley JB.. Novoseven use in a non-cardiac pediatric ECMO patient with uncontrolled bleeding. J Extra Corpor Technol. 2008 ; 40: 123-126
12. Guzzetta NA, Huch S, Fernandez JD, Tosone SR, Miller BE.. Use of recombinant factor VIIa for uncontrolled bleeding in neonates after cardiopulmonary bypass. Paediatr Anaesth. 2009 ; 19: 364-370
13. Niebler RA, Punzalan RC, Marchan M, Lankiewicz MW.. Activated recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2010 ; 11: 98-102
14. Chalwin RP, Tiruvoipati R, Peek GJ.. Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation. Eur J Cardiothorac Surg. 2008 ; 34: 685-686
15. Syburra T, Lachat M, Genoni M, Wilhelm MJ.. Fatal outcome of recombinant factor VIIa in heart transplantation with extracorporeal membrane oxygenation. Ann Thorac Surg. 2010 ; 89: 1643-1645
16. Warren OJ, Rogers PL, Watret AL, et al. Defining the role of recombinant activated factor VII in pediatric cardiac surgery: where should we go from here?. Pediatr Crit Care Med. 2009 ; 10: 572-582
17. Dominguez TE, Brown KL.. Activated recombinant factor VII and extracorporeal membrane oxygenation: everything is all right, nothing is wrong?. Pediatr Crit Care Med. 2010 ; 11: 155-156
18. McMullan DM, Emmert JA, Permut LC, et al. Minimizing bleeding associated with mechanical circulatory support following pediatric heart surgery. Eur J Cardiothorac Surg. 2011 ; 39: 392-397
19. Majno G, Joris I. Cells, tissues, and disease: principles of general pathology. 2nd Ed New York, NY: Oxford University Press ; 2004 :