Impact of AMICAR on hemorrhagic complications of ECMO: A ten-year review

Journal of Pediatric Surgery

Volumn 38, Issue 8, 2003, Pages 1212-1216

  Downard, Cynthia D ^a   Betit, Peter ^a   Chang, Robert W ^a   Garza, Jennifer J ^a   Arnold, John H ^a   Wilson, Jay M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Aminocaproic acid; Complications; Extracorporeal membrane oxygenation; Hemorrhage

Indexed keywords

AMINOCAPROIC ACID;

ADULT; BLEEDING; BRAIN HEMORRHAGE; CHI SQUARE TEST; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EXTRACORPOREAL OXYGENATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; NEWBORN; POSTOPERATIVE HEMORRHAGE; PRESCHOOL CHILD; PRIORITY JOURNAL; REGISTER; REVIEW; SURGICAL WOUND; SURVIVAL RATE; UNITED STATES;

EID: 0041358888     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(03)00270-7     Document Type: Article

References (6)

1. Ackerman N, Lyon J, Ratner I, et al: A proposal for a multicenter trial of 6-amino-hexanoic acid (AMICAR) for the prevention of bleeding of infants on ECMO. Presented at the 2nd Annual Extracorporeal Life Support Organization Meeting, Ann Arbor, MI, November, 1990
2. Wilson JM, Bower LK, Fackler JC, et al: Aminocaproic acid decreases the incidence of intracranial hemorrhage and other hemorrhagic complications of ECMO. J Pediatr Surg 28:536-540, 1993
3. Bartlett RH, Andrews AF, Toomasian JM, et al: Extracorporeal membrane oxygenation for newborn respiratory failure: Forty-five cases. Surgery 92:425-433, 1982
4. Horwitz JR, Cofer BR, Warner BW, et al: A multicenter trial of 6-aminocaproic acid (Amicar) in the prevention of bleeding in infants on ECMO. J Pediatr Surg 33:1610-1613, 1998
5. Lally KP, Paranka MS, Roden J, et al: Congenital diaphragmatic hernia. Stabilization and repair on ECMO. Ann Surg 216:569-573, 1992
6. Hocker JR, Saving KL: Fatal aortic thrombosis in a neonate during infusion of epsilon-aminocaproic acid. J Pediatr Surg 30:1490-1492, 1995