Effect of WFDC 2 silencing on the proliferation, motility and invasion of human serous ovarian cancer cells in vitro

Asian Pacific Journal of Tropical Medicine

Volumn 6, Issue 4, 2013, Pages 265-272

  Zhu, Ya Fei ^a   Gao, Guo Lan ^a   Tang, Sheng Bo ^a   Zhang, Zhen Dong ^a   Huang, Qing Shui ^b  

^a NANCHANG UNIVERSITY   (China)

^b Aviation General Hospital   (China)

Author keywords

Cell movement; Cell proliferation; Human epididymal secretory protein 4; Invasion; Ovarian neoplasms; WFDC2 protein

Indexed keywords

CASPASE 3; CATHEPSIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; OLIGONUCLEOTIDE; PROTEIN BCL 2; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENE SILENCING; HE4 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEROUS OVARIAN CANCER; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENETIC VECTORS; HUMANS; LENTIVIRUS; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84876705600     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(13)60055-3     Document Type: Article

References (14)

1. Urban N, McIntosh MW, Andersen M, Karlan BY Ovarian cancer screening. Hematol Oncol Clin North Am 2003, 17(4):989-1005. ix.
2. Zhu YF, Gao GL, Huang QS Diagnostic value of serum human epididymis protein 4 in human epithelial ovarian cancer: A meta-analysis. Chin J Clin Oncol 2011, 38(24):1559-1564.
3. Karlsen MA, Sandhu N, Høgdall C, Christensen IJ, Nedergaard L, Lundvall L, et al. Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk ofmalignancy index (RMI) as diagnostic tools of epithelial ovarian cancer inpatients with a pelvic mass. Gynecol Oncol 2012, 127(2):379-383.
4. Braicu EI, Fotopoulou C, Van Gorp T, Richter R, Chekerov R, Hall C, et al. Preoperative HE4 expression in plasma predicts surgical outcome in primaryovarian cancer patients: Results from the OVCAD study. Gynecol Oncol 2012, 128(2):245-251.
5. Trudel D, Têtu B, Grégoire J, Plante M, Renaud MC, Bachvarov D, et al. Human epididymis protein 4 (HE4) and ovarian cancer prognosis. Gynecol Oncol 2012, 127(3):511-515.
6. Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res 2005, 65(6):2162-2169.
7. Chen J, Xie J Progress on RNAi-based molecular medicines. Int J Nanomedicine 2012, 7:3971-3980.
8. Chen Y, Mu X, Wang S, Zhao L, Wu Y, Li J, et al. WAP four-disulfide core domain protein 2 mediates the proliferation of humanovarian cancer cells through the regulation of growth- and apoptosis-associatedgenes. Oncol Rep 2013, 29(1):288-296.
9. Nakata A, Gotoh N Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lungcancer. Expert Opin Ther Targets 2012, 16(8):771-781.
10. Sheng Q, Liu J The therapeutic potential of targeting the EGFR family in epithelial ovariancancer. Br J Cancer 2011, 104(8):1241-1245.
11. Roomi MW, Kalinovsky T, Rath M, Niedzwiecki A Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human female cancer cell lines. Oncol Rep 2012, 28(3):768-776.
12. Scott A, Weldon S, Taggart CC SLPI and elafin: multifunctional antiproteases of the WFDC family. Biochem Soc Trans 2011, 39(5):1437-1440.
13. Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, et al. WFDC2 (HE4): a potential role in the innate immunity of the oral cavity andrespiratory tract and the development of adenocarcinomas of the lung. Respir Res 2006, 7:61.
14. Chhikara N, Saraswat M, Tomar AK, Dey S, Singh S, Yadav S Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. PLOS One 2012, 7(11):e47672.