In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat

Toxicology in Vitro

Volumn 27, Issue 5, 2013, Pages 1451-1457

  Choi, Kyoungju ^a   Joo, Hyun ^a   Campbell, Jerry L ^a   Andersen, Melvin E ^a   Clewell, Harvey J ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

DEHP; Human; In vitro hepatic metabolism; In vitro intestinal metabolism; Intrinsic clearance; Rat

Indexed keywords

CYTOCHROME; CYTOCHROME P450 2C6; CYTOCHROME P450 2C9 1; CYTOCHROME P450 2C9 2; CYTOCHROME P450 2C9 3; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; ESTERASE; MONO(2 ETHYL 5 HYDROXYHEXYL)PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL)PHTHALATE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME METABOLISM; FEMALE; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; INTESTINE FUNCTION; INTESTINE METABOLISM; LIVER METABOLISM; MALE; METABOLITE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SPECIES DIFFERENCE; TOXICOKINETICS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLHEXYL PHTHALATE; FEMALE; HUMANS; INTESTINES; LIVER; MALE; MICROSOMES; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; YOUNG ADULT;

RATTUS;

EID: 84876698279     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.03.012     Document Type: Article

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