Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 3028-3033

  Liu, Chunjian ^a   Lin, James ^a   Everlof, Gerry ^a   Gesenberg, Christoph ^a   Zhang, Hongjian ^a   Marathe, Punit H ^a   Malley, Mary ^a   Galella, Michael A ^a   McKinnon, Murray ^a   Dodd, John H ^a   Barrish, Joel C ^a   Schieven, Gary L ^a   Leftheris, Katerina ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Prodrugs Carbamoylmethylene linked prodrugs Prodrugs of secondary amides

Indexed keywords

ANTIRHEUMATIC AGENT; BMS 582949; CARBAMOYLMETHYLENE; FUMARIC ACID; PRODRUG; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; PH;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DACARBAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PRODRUGS; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TRIAZINES;

EID: 84876692329     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.022     Document Type: Article

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