The distressing overuse of gastric acid inhibitors

Digestive Diseases and Sciences

Volumn 58, Issue 3, 2013, Pages 600-601

  Fossmark, Reidar ^a,b   Waldum, Helge ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR;

CLOSTRIDIUM DIFFICILE INFECTION; DRUG MECHANISM; EDITORIAL; ENERGY EXPENDITURE; HUMAN; INFECTION RISK; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; PROPHYLAXIS; RESPIRATORY TRACT INFECTION; STOMACH ACID SECRETION; STOMACH PH; STRESS ULCER;

ANTI-ULCER AGENTS; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; PHYSICIANS; STRESS, PHYSIOLOGICAL; ULCER;

EID: 84876691437     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2532-6     Document Type: Editorial

References (23)

1. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 2005;96:94-102.
2. Wilder-Smith CH, Spirig C, Krech T, Merki H. Bactericidal factors in gastric juice. Eur J Gastroenterol Hepatol. 1992;4:885-891.
3. Weiss C, Clark HF. Rapid inactivation of rotaviruses by exposure to acid buffer or acidic gastric juice. J Gen Virol. 1985;66:2725-2730.
4. Martinsen TC, Benestad SL, Moldal T, Waldum HL. Inhibitors of gastric acid secretion increase the risk of prion infection in mice. Scand J Gastroenterol. 2011;46(12):1418-1422. doi: 10.3109/00365521.2011.619277.
5. Sethbhakdi S, Pfeiffer CJ, Roth JL. Gastric mucosal ulceration following vasoactive agents. A new experimental model. Am J Dig Dis. 1970;15:261-270.
6. Menguy R, Masters YF. Mechanism of stress ulcer. 3. Effects of hemorrhagic shock on energy metabolism in the mucosa of the antrum, corpus, and fundus of the rabbit stomach. Gastroenterology. 1974;66:1168-1176.
7. Brown TH, Davidson PF, Larson GM. Acute gastritis occurring within 24 hours of severe head injury. Gastrointest Endosc. 1989;35:37-40.
8. Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J. Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med. 1999;27:2812-2817.
9. Waldum HL, Marvik R, Gronbech JE, Sandvik AK, Aase S. Oxyntic lesions may be provoked in the rat both by the process of acid secretion and also by gastric acidity. Aliment Pharmacol Ther. 2000;14:135-141.
10. Demitrack ES, Aihara E, Kenny S, Varro A, Montrose MH. Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage. Gut. 2012;61:804-811. doi: 10.1136/gutjnl-2011-300420.
11. Koczka CP, Geraldino-Pardilla LB, Goodman AJ. Physicians' opinions of stress ulcer prophylaxis: survey results from a large urban medical center. Dig Dis Sci. 2012. (Epub ahead of print). doi: 10.1007/s10620-012-2423-x.
12. Giannella RA, Broitman SA, Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972;13:251-256.
13. Lewis SJ, Franco S, Young G, O'Keefe SJ. Altered bowel function and duodenal bacterial overgrowth in patients treated with omeprazole. Aliment Pharmacol Ther. 1996;10:557-561.
14. Howell MD, Novack V, Grgurich P, et al. Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med. 2010;170:784-790. doi: 10.1001/archinternmed.2010.89.
15. Trikudanathan G, Israel J, Cappa J, O'Sullivan DM. Association between proton pump inhibitors and spontaneous bacterial peritonitis in cirrhotic patients - a systematic review and meta-analysis. Int J Clin Pract. 2011;65:674-678. doi: 10.1111/j.1742-1241.2011.02650.x.
16. Thuluvath PJ, Morss S, Thompson R. Spontaneous bacterial peritonitis - in-hospital mortality, predictors of survival, and health care costs from 1988 to 1998. Am J Gastroenterol. 2001;96:1232-1236. doi: 10.1111/j.1572-0241.2001. 03708.x.
17. Prod'hom G, Leuenberger P, Koerfer J, et al. Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med. 1994;120:653-662.
18. de Jager CP, Wever PC, Gemen EF, et al. Proton pump inhibitor therapy predisposes to community-acquired Streptococcus pneumoniae pneumonia. Aliment Pharmacol Ther. 2012. doi: 10.1111/apt.12069.
19. Cook DJ, Griffith LE, Walter SD, et al. The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. Critical Care (London, England). 2001;5:368-375.
20. Reimer C, Bytzer P. Clinical trial: long-term use of proton pump inhibitors in primary care patients - a cross sectional analysis of 901 patients. Aliment Pharmacol Ther. 2009;30:725-732. doi: 10.1111/j.1365-2036. 2009.04092.x.
21. Jacobson BC, Ferris TG, Shea TL, Mahlis EM, Lee TH, Wang TC. Who is using chronic acid suppression therapy and why? Am J Gastroenterol. 2003;98:51-58. doi: 10.1111/j.1572-0241.2003.07186.x.
22. Waldum HL, Arnestad JS, Brenna E, Eide I, Syversen U, Sandvik AK. Marked increase in gastric acid secretory capacity after omeprazole treatment. Gut. 1996;39:649-653.
23. Reimer C, Sondergaard B, Hilsted L, Bytzer P. Proton pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology. 2009;137:80-87.