Moderate superficial hypothermia prolongs bleeding time in humans

Acta Anaesthesiologica Scandinavica

Volumn 51, Issue 2, 2007, Pages 198-201

  Romlin, B ^a   Petruson, K ^b   Nilsson, K ^a  

^a QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bleeding time; Coagulation; Local hypothermia; Thrombelastograph; Volunteers

Indexed keywords

ADULT; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; COOLING; CORE TEMPERATURE; ENVIRONMENTAL TEMPERATURE; FEMALE; FOREARM; HUMAN; LOW TEMPERATURE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SKIN TEMPERATURE; TEMPERATURE MEASUREMENT; THERMISTOR; THROMBOELASTOGRAPHY;

ADULT; BLEEDING TIME; BLOOD COAGULATION; FEMALE; HUMANS; HYPOTHERMIA; HYPOTHERMIA, INDUCED; MALE; MIDDLE AGED; SKIN TEMPERATURE; THROMBELASTOGRAPHY;

EID: 33846411436     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2006.01181.x     Document Type: Article

References (14)

1. Sessler DI. Mild perioperative hypothermia. N Engl J Med 1997; 336: 1730-7.
2. Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A. Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. The Lancet 1996; 347: 289-92.
3. Valeri CR, Feingold H, Cassidy G, Ragno G, Khuri SF, Altschule M. Hypothermia-induced reversible platelet dysfunction. Ann Surg 1987; 205: 175-81.
4. Michelson AD, Barnard MR, Kuhuri SF, Rohrer MJ, MacGregor H, Valeri CR. The effects of aspirin and hypothermia on platelet function in vivo. Br J Haematol 1999; 104: 64-8.
5. Valeri CR, Khabbaz K, Khuri SF, Marquardt C, Ragno G, Feingold H et al. Effect of skin temperature on platelet function in patients undergoing extracorporeal bypass. J Thorac Cardiovasc Surg 1992; 104: 108-16.
6. Harker LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. New Engl J Med 1972; 287: 155-9.
7. Traverso CI, Caprini JA, Arcelus JI. The normal thromboelastogram and its interpretation. Semin Thromb Hemost 1995; 21: 7-13.
8. Khuri SF, Wolfe AJ, Josa M, Axford TC, Szymanski I, Assousa S et al. Hematologic changes during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss. J Thorac Cardiovasc Surg 1992; 104: 94-107.
9. Reed RI, Johnston TD, Hudson JD, Fisher RP. The disparity between hypothermic coagulopathy and clotting studies. J Trauma 1992; 33: 465-70.
10. Kettner SC, Sitzwohl C, Zimpfer M, Kozek SA, Holzer A, Spiss CK et al. The effect graded hypothermia (36°C-32°C) hemostasis anesthetized patients without surgical trauma. Anesth Analg 2003; 96: 1772-6.
11. Wolberg AS, Meng ZH, Monroe DM, Hoffman M. A systematic evaluation of the effect of temperature coagulation enzyme activity platelet function. J Trauma 2004; 56: 1221-8.
12. Maurer-Spurej E, Pfeiler G, Maurer N, Lindner H, Glatter O, Devine DV. Room temperature activates human blood platelets. Laboratory Investigation 2001; 81: 581-92.
13. Faraday N, Rosenfeld BA. In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression. Anesthesiology 1998; 88: 1579-85.
14. Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR. Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost 1994; 71: 633-40.