Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage i esophageal squamous cell carcinoma

Cancer

Volumn 119, Issue 9, 2013, Pages 1752-1760

  Lee, Eunju ^a   Lee, Bo Bin ^a   Ko, Eunkyung ^a   Kim, Yujin ^a   Han, Jungho ^a   Shim, Young Mog ^a   Park, Joobae ^a   Kim, Duk Hwan ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

DCC; esophageal cancer; hypermethylation; p14; recurrence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPIDERMAL GROWTH FACTOR RECEPTOR; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CADM1 GENE; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; DCC GENE; DISEASE ASSOCIATION; DNA METHYLATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; FOLLOW UP; GENE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; P14 GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; RETROSPECTIVE STUDY;

AGED; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; DNA METHYLATION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POLYMERASE CHAIN REACTION; PROGNOSIS; RECEPTORS, CELL SURFACE; RETROSPECTIVE STUDIES; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEINS;

EID: 84876687658     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27948     Document Type: Article

References (18)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D,. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM,. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127: 2893-2917.
3. Herman JG, Baylin SB,. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003; 349: 2042-2054.
4. Greene F, Page D, Fleming I, et al. Esophagus. In:, Edge SB, ed. AJCC Cancer Staging Manual. 6th ed. New York: Springer-Verlag; 2002: 91-95.
5. Lee EJ, Lee BB, Han J, et al. CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma. Int J Cancer. 2008; 123: 2073-2079.
6. Ling Y, Huang G, Fan L, et al. CpG island methylator phenotype of cell-cycle regulators associated with TNM stage and poor prognosis in patients with oesophageal squamous cell carcinoma. J Clin Pathol. 2011; 64: 246-251.
7. Huang Y, Peters CJ, Fitzgerald RC, Gjerset RA,. Progressive silencing of p14ARF in oesophageal adenocarcinoma. J Cell Mol Med. 2009; 13: 398-409.
8. Ito S, Ohga T, Saeki H, et al. Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and p16INK4a) gene in esophageal squamous cell carcinoma. Anticancer Res. 2007; 27: 3345-3353.
9. Park HL, Kim MS, Yamashita K, et al. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008; 122: 2498-2502.
10. Ito T, Shimada Y, Hashimoto Y, et al. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res. 2003; 63: 6320-6326.
11. Kikuchi S, Yamada D, Fukami T, et al. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma. Cancer. 2006; 106: 1751-1758.
12. Ko E, Park SE, Cho EY, et al. Cystatin M loss is associated with the losses of estrogen receptor, progesterone receptor, and HER4 in invasive breast cancer [serial online]. Breast Cancer Res. 2010; 12: R100.
13. Castets M, Broutier L, Molin Y, et al. DCC constrains tumour progression via its dependence receptor activity. Nature. 2012; 482: 534-537.
14. Krimpenfort P, Song J-Y, Proost N, Zevenhoven J, Jonkers J, Berns A,. Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. Nature. 2012; 482: 538-541.
15. Kuramochi M, Fukuhara H, Nobukuni T, et al. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet. 2001; 27: 427-430.
16. Masuda M, Yageta M, Fukuhara H, et al. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem. 2002; 277: 31014-31019.
17. Shingai T, Ikeda W, Kakunaga S, et al. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 2003; 278: 35421-35427.
18. Yageta M, Kuramochi M, Masuda M, et al. Direct association of TSLC1 and DAL-1, 2 distinct tumor suppressor proteins in lung cancer. Cancer Res. 2002; 62: 5129-5133.