Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Martins, Yuri C ^a,b   Clemmer, Leah ^a   Orjuela Sánchez, Pamela ^a   Zanini, Graziela M ^a,c   Ong, Peng Kai ^a   Frangos, John A ^a   Carvalho, Leonardo Jm ^a,d  

^a LA JOLLA BIOENGINEERING INSTITUTE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Funda??o Oswaldo Cruz   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Adjunctive therapy; Blood pressure; ECG; Experimental cerebral malaria; Nimodipine

Indexed keywords

ARTESUNATE; NIMODIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; BRAIN MALARIA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ELECTROCARDIOGRAM; HEART RATE VARIABILITY; HYPOTENSION; MALE; MOUSE; NONHUMAN; OSMOTIC PUMP; PR INTERVAL; QRS COMPLEX; QT DISPERSION; QT INTERVAL; SURVIVAL; TREATMENT RESPONSE;

ADMINISTRATION, INTRAVENOUS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIMALARIALS; ARTEMISININS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FEMALE; MALARIA, CEREBRAL; MICE; MICE, INBRED C57BL; NIMODIPINE; PLASMODIUM BERGHEI; SALVAGE THERAPY; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84876683779     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-138     Document Type: Article

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