Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: Identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats

Planta Medica

Volumn 79, Issue 6, 2013, Pages 471-479

  Gao, Qiong ^a   Zhang, Yufeng ^b   Wo, Siukwan ^a   Zuo, Zhong ^a  

^a Prince of Wales Hospital   (Hong Kong)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

arctigenic acid; arctigenin; Arctium lappa; Asteraceae; hydrolysis; paraoxonase 1

Indexed keywords

4 O DEMETHYLARCTIGENIN; ARCTIGENIC ACID; ARCTIGENIN; ARCTIGENIN 4 O' GLUCURONIDE; ARCTIGENIN 4' O SULFATE; ARYLDIALKYLPHOSPHATASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARCTIUM LAPPA; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME KINETICS; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; FURANS; HYDROLYSIS; KINETICS; LIGNANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLASMA; RATS; TANDEM MASS SPECTROMETRY;

ARCTIUM; ARCTIUM LAPPA; ASTERACEAE; RATTUS;

EID: 84876669797     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328332     Document Type: Article

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