Bifunctional epitope-agonist ligands of the bradykinin B2 receptor

Biological Chemistry

Volumn 394, Issue 3, 2013, Pages 379-383

  Gera, Lajos ^a   Roy, Caroline ^b   Marceau, François ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

antibody cargo; B2 receptor; bradykinin

Indexed keywords

ANATIBANT; BETA ARRESTIN; BRADYKININ B2 RECEPTOR; EPITOPE; GREEN FLUORESCENT PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOFLUORESCENCE; BINDING COMPETITION; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; EPIFLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR AFFINITY; STEREOSPECIFICITY; STOICHIOMETRY; SURFACE PROPERTY; UMBILICAL VEIN; WILD TYPE;

AMINO ACID SEQUENCE; DRUG DESIGN; ENDOCYTOSIS; EPITOPES; GENES, MYC; HEK293 CELLS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; RECEPTOR, BRADYKININ B2;

ORYCTOLAGUS CUNICULUS;

EID: 84876587239     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0286     Document Type: Article

References (7)

1. Bawolak, M-T., Gera, L., Stewart, J.M., and Marceau, F. (2007). B-9972 (D-Arg-[Hyp 3, Igl 5, Oic 7, Igl 8 ]-bradykinin) is an inactivationresistant agonist of the bradykinin B 2 receptor derived from the peptide antagonist B-9430 (D-Arg-[Hyp 3, Igl 5, D-Igl 7, Oic 8 ]-bradykinin): Pharmacologic profile and effective induction of receptor degradation. J. Pharmacol. Exp. Ther. 323, 534-546.
2. Bawolak, M.T., Lodge, R., Morissette, G., and Marceau, F. (2011). Bradykinin B 2 receptor-mediated transport into intact cells: Anti-receptor antibody-based cargoes. Eur. J. Pharmacol. 668, 107-114.
3. Bawolak, M.T., Roy, C., Gera, L., and Marceau, F. (2012). Prolonged signalling and trafficking of the bradykinin B 2 receptor stimulated with the amphibian peptide maximakinin: Insight into the endosomal inactivation of kinins. Pharmacol. Res. 65, 247-253.
4. Gera, L., Bawolak, M-T., Roy, C., Lodge, R., and Marceau, F. (2011). Design of fluorescent bradykinin analogs: Application to imaging of B 2 receptor-mediated agonist endocytosis and trafficking and of angiotensin-converting enzyme. J. Pharmacol. Exp. Ther. 337, 33-41.
5. Gera, L., Roy, C., Bawolak, M.T., Charest-Morin, X., and Marceau, F (2012). N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: Structure - activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes. Peptides 34, 433-446.
6. Leeb-Lundberg, L.M.F., Marceau, F., M ü ller-Esterl, W., Pettibone, D.J., and Zuraw, B.L. (2005). International Union of Pharmacology. XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequences. Pharmacol. Rev. 57, 27-77.
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