-
1
-
-
77951776390
-
Genetics, pathogenesis and clinical interventions in type 1 diabetes
-
Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010;464:1293-1300
-
(2010)
Nature
, vol.464
, pp. 1293-1300
-
-
Bluestone, J.A.1
Herold, K.2
Eisenbarth, G.3
-
2
-
-
78651074199
-
Proinsulin/C-peptide ratio, glucagon and remission in newonset Type 1 diabetes mellitus in young adults
-
Diabetes Incidence Study Group in Sweden (DISS)
-
Schölin A, Nyström L, Arnqvist H, et al.; Diabetes Incidence Study Group in Sweden (DISS). Proinsulin/C-peptide ratio, glucagon and remission in newonset Type 1 diabetes mellitus in young adults. Diabet Med 2011;28:156-161
-
(2011)
Diabet Med
, vol.28
, pp. 156-161
-
-
Schölin, A.1
Nyström, L.2
Arnqvist, H.3
-
3
-
-
67649933375
-
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years
-
Immune Tolerance Network ITN007AI Study Group
-
Herold KC, Gitelman S, Greenbaum C, et al.; Immune Tolerance Network ITN007AI Study Group. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol 2009;132:166-173
-
(2009)
Clin Immunol
, vol.132
, pp. 166-173
-
-
Herold, K.C.1
Gitelman, S.2
Greenbaum, C.3
-
4
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
DOI 10.2337/diabetes.54.6.1763
-
Herold KC, Gitelman SE, Masharani U, et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54:1763-1769 (Pubitemid 40770766)
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-1769
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
Hagopian, W.4
Bisikirska, B.5
Donaldson, D.6
Rother, K.7
Diamond, B.8
Harlan, D.M.9
Bluestone, J.A.10
-
5
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
DOI 10.1056/NEJMoa043980
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005;352:2598-2608 (Pubitemid 41007846)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
Gorus, F.7
Goldman, M.8
Walter, M.9
Candon, S.10
Schandene, L.11
Crenier, L.12
De Block, C.13
Seigneurin, J.-M.14
De Pauw, P.15
Pierard, D.16
Weets, I.17
Rebello, P.18
Bird, P.19
Berrie, E.20
Frewin, M.21
Waldmann, H.22
Bach, J.-F.23
Pipeleers, D.24
Chatenoud, L.25
more..
-
6
-
-
79960912796
-
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebo-controlled trial
-
Type 1 Diabetes TrialNet Abatacept Study Group
-
Orban T, Bundy B, Becker DJ, et al.; Type 1 Diabetes TrialNet Abatacept Study Group. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011;378:412-419
-
(2011)
Lancet
, vol.378
, pp. 412-419
-
-
Orban, T.1
Bundy, B.2
Becker, D.J.3
-
7
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
-
Type 1 Diabetes TrialNet Anti-CD20 Study Group
-
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, et al.; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 2009;361:2143-2152
-
(2009)
N Engl J Med
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
Greenbaum, C.J.2
Krause-Steinrauf, H.3
-
8
-
-
79957899130
-
Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes
-
Waldron-Lynch F, Herold KC. Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes. Nat Rev Drug Discov 2011;10:439-452
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 439-452
-
-
Waldron-Lynch, F.1
Herold, K.C.2
-
9
-
-
33845523340
-
Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes
-
DOI 10.2337/db05-1034
-
Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 2006;55:3238-3245 (Pubitemid 44923579)
-
(2006)
Diabetes
, vol.55
, Issue.12
, pp. 3238-3245
-
-
Sherry, N.A.1
Kushner, J.A.2
Glandt, M.3
Kitamura, T.4
Brillantes, A.-M.B.5
Herold, K.C.6
-
10
-
-
82755197361
-
Detection of β cell death in diabetes using differentially methylated circulating DNA
-
Akirav EM, Lebastchi J, Galvan EM, et al. Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci USA 2011;108:19018-19023
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 19018-19023
-
-
Akirav, E.M.1
Lebastchi, J.2
Galvan, E.M.3
-
11
-
-
70350044885
-
DNA demethylation in hormone-induced transcriptional derepression
-
Kim MS, Kondo T, Takada I, et al. DNA demethylation in hormone-induced transcriptional derepression. Nature 2009;461:1007-1012
-
(2009)
Nature
, vol.461
, pp. 1007-1012
-
-
Kim, M.S.1
Kondo, T.2
Takada, I.3
-
12
-
-
70349138460
-
Insulin gene expression is regulated by DNA methylation
-
Kuroda A, Rauch TA, Todorov I, et al. Insulin gene expression is regulated by DNA methylation. PLoS ONE 2009;4:e6953
-
(2009)
PLoS ONE
, vol.4
-
-
Kuroda, A.1
Rauch, T.A.2
Todorov, I.3
-
13
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
DOI 10.1056/NEJMoa012864
-
Herold KC, Hagopian W, Auger JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002;346:1692-1698 (Pubitemid 34547482)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
14
-
-
80051471700
-
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-Year results from a randomised, placebo-controlled trial
-
Protégé Trial Investigators
-
Sherry N, Hagopian W, Ludvigsson J, et al.; Protégé Trial Investigators. Teplizumab for treatment of type 1 diabetes (Proté gé study): 1-year results from a randomised, placebo-controlled trial. Lancet 2011;378:487-497
-
(2011)
Lancet
, vol.378
, pp. 487-497
-
-
Sherry, N.1
Hagopian, W.2
Ludvigsson, J.3
-
15
-
-
84876095279
-
Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: A randomised controlled trial
-
Herold KC, Gitelman SE, Willi SM, et al. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia 2013;56:391-400
-
(2013)
Diabetologia
, vol.56
, pp. 391-400
-
-
Herold, K.C.1
Gitelman, S.E.2
Willi, S.M.3
-
16
-
-
0023784346
-
IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans
-
Campbell IL, Iscaro A, Harrison LC. IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans. J Immunol 1988;141:2325-2329
-
(1988)
J Immunol
, vol.141
, pp. 2325-2329
-
-
Campbell, I.L.1
Iscaro, A.2
Harrison, L.C.3
-
18
-
-
55849116389
-
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
-
Skowera A, Ellis RJ, Varela-Calviño R, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008;118:3390-3402
-
(2008)
J Clin Invest
, vol.118
, pp. 3390-3402
-
-
Skowera, A.1
Ellis, R.J.2
Varela-Calviño, R.3
-
19
-
-
70350343033
-
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation
-
Fujimoto K, Hanson PT, Tran H, et al. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem 2009;284:27664-27673
-
(2009)
J Biol Chem
, vol.284
, pp. 27664-27673
-
-
Fujimoto, K.1
Hanson, P.T.2
Tran, H.3
|