Real-time in vivo imaging of sizedependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy

Interface Focus

Volumn 3, Issue 3, 2013, Pages

  Browning, Lauren M ^a   Huang, Tao ^a   Xu, Xiao Hong Nancy ^a  

^a OLD DOMINION UNIVERSITY   (United States)

Author keywords

In vivo assays; In vivo imaging; Nanotoxicity; Single nanoparticle imaging and diffusion; Single nanoparticle plasmonic spectroscopy; Zebrafish embryos

Indexed keywords

EID: 84876520703     PISSN: 20428898     EISSN: 20428901     Source Type: Journal    
DOI: 10.1098/rsfs.2012.0098     Document Type: Article

References (43)

1. Bohren CF, Huffman DR. 1983 Absorption and scattering of light by small particles, pp. 287-380. New York, NY: Wiley.
2. Kreibig U, Vollmer M. 1995 Optical properties of metal clusters, pp. 14-123. Berlin, Germany: Springer.
3. Mie G. 1908 Beiträg zur optik trüber medien, speziell kolloidaler metralló́sungen. Annu. Phys. 25, 377-445. (doi:10.1002/andp.19083300302)
4. Kelly KL, Coronado E, Zhao LL, Schatz GC. 2003 The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J. Phys. Chem. B 107, 668-677. (doi:10.1021/jp026731y)
5. Mulvaney P. 1996 Surface plasmon spectroscopy of nanosized metal particles. Langmuir 12, 788-800. (doi:10.1021/la9502711)
6. Lee KS, El-Sayed MA. 2006 Gold and silver nanoparticles in sensing and imaging: sensitivity of plasmon response to size, shape, and metal composition. J. Phys. Chem. B 110, 19 220-19 225. (doi:10.1021/jp062536y)
7. Nallathamby PD, Huang T, Xu X-HN. 2010 Design and characterization of optical nano rulers of single nanoparticles using optical microscopy and spectroscopy. Nanoscale 2, 1715-1722. (doi:10.1039/ c0nr00303d)
8. Huang T, Nallathamby PD, Gillet D, Xu X-HN. 2007 Design and synthesis of single nanoparticle optical biosensors for imaging and characterization of single receptor molecules on single living cells. Anal. Chem. 79, 7708-7718. (doi:10.1021/ ac0709706)
9. Huang T, Nallathamby PD, Xu X-HN. 2008 Photostable single-molecule nanoparticle optical biosensors for real-time sensing of single cytokine molecules and their binding reactions. J. Am. Chem. Soc. 130, 17 095-17 105. (doi:10.1021/ja8068853)
10. Lee KJ, Browning LM, Huang T, Ding F, Nallathamby PD, Xu X-HN. 2010 Probing of multidrug ABC membrane transporters of single living cells using single plasmonic nanoparticle optical probes. Anal. Bioanal. Chem. 397, 3317-3328. (doi:10.1007/ s00216-010-3864-8)
11. Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu X-HN. 2007 In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1, 133-143. (doi:10.1021/nn700048y)
12. Nallathamby PD, Lee KJ, Desai T, Xu X-HN. 2010 Study of multidrug membrane transporters of single living Pseudomonas aeruginosa cells using sizedependent plasmonic nanoparticle optical probes. Biochemistry 49, 5942-5953. (doi:10.1021/ bi100268k)
13. Nallathamby PD, Lee KJ, Xu X-HN. 2008 Design of stable and uniform single nanoparticle photonics for in vivo dynamics imaging of nanoenvironments of zebrafish embryonic fluids. ACS Nano 2, 1371-1380. (doi:10.1021/nn800048x)
14. Xu X-HN, Brownlow WJ, Kyriacou SV, Wan Q, Viola JJ. 2004 Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging. Biochemistry 43, 10 400-10 413. (doi:10.1021/bi036231a)
15. Xu X-HN, Chen J, Jeffers RB, Kyriacou SV. 2002 Direct measurement of sizes and dynamics of single living membrane transporters using nano-optics. Nano Lett. 2, 175-182. (doi:10.1021/nl015682i)
16. Browning LM, Lee KJ, Huang T, Nallathamby PD, Lowman J, Xu X-HN. 2009 Random walk of single gold nanoparticles in zebrafish embryos leading to stochastic toxic effects on embryonic developments. Nanoscale 1, 138-152. (doi:10.1039/b9nr00053d)
17. Huang T, Browning LM, Xu X-HN. 2012 Far-field photostable optical nanoscopy (PHOTON) for realtime super-resolution single-molecular imaging of signaling pathways of single live cells. Nanoscale 4, 2797-2812. (doi:10.1039/c2nr11739h)
18. Lee KJ, Browning LM, Nallathamby PD, Desai T, Cherukui P, Xu X-HN. 2012 In vivo quantitative study of size-dependent transport and toxicity of single silver nanoparticles using zebrafish embryos. Chem. Res. Toxicol. 25, 1029-1046. (doi:10.1021/ tx300021u)
19. Lee KJ, Nallathamby PD, Browning LM, Desai T, Cherukui P, Xu X-HN. 2012 Single nanoparticle spectroscopy for real-time in vivo quantitative analysis of transport and toxicity of single nanoparticles in single embryos. Analyst 137, 2973-2986. (doi:10.1039/c2an35293a)
20. Nallathamby PD, Xu X-HN. 2010 Study of cytotoxic and therapeutic effects of stable and purified silver nanoparticles on tumor cells. Nanoscale 2, 942-952. (doi:10.1039/c0nr00080a)
21. Kyriacou SV, Brownlow WJ, Xu XHN. 2004 Using nanoparticle optics assay for direct observation of the function of antimicrobial agents in single live bacterial cells. Biochemistry 43, 140-147. (doi:10. 1021/bi0351110)
22. Huang T, Xu X-HN. 2011 Multicolored nanometerresolution mapping of single protein-ligand binding complex using far-field photostable optical nanoscopy (PHOTON). Nanoscale 3, 3567-3572. (doi:10.1039/c1nr10182j)
23. Murphy CJ, Gole AM, Stone JW, Sisco PN, Alkilany AM, Goldsmith EC, Baxter SC. 2008 Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc. Chem. Res. 41, 1721-1730. (doi:10. 1021/ar800035u)
24. Dreaden EC, El-Sayed MA. 2012 Detecting and destroying cancer cells in more than one way with noble metals and different confinement properties on the nanoscale. Acc. Chem. Res. 45, 1854-1865. (doi:10.1021/ar2003122)
25. Bhattacharya R, Mukherjee P. 2008 Biological properties of 'naked' metal nanoparticles. Adv. Drug Deliv. Rev. 60, 1289-1306. (doi:10.1016/j.addr. 2008.03.013)
26. Khlebtsov N, Dykman L. 2011 Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem. Soc. Rev. 40, 1647-1671. (doi:10.1039/c0cs00018c)
27. Fadeel B, Garcia-Bennett AE. 2010 Better safe than sorry: understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. Adv. Drug Deliv. Rev. 62, 362-374. (doi:10.1016/j.addr.2009.11.008)
28. Fischer HC, Chan WC. 2007 Nanotoxicity: the growing need for in vivo study. Curr. Opin. Biotechnol. 18, 565-571. (doi:10.1016/j.copbio.2007.11.008)
29. Hill AJ, Teraoka H, Heideman W, Peterson RE. 2005 Zebrafish as a model vertebrate for investigating chemical toxicity. Toxicol. Sci. 86, 6-19. (doi:10. 1093/toxsci/kfi110)
30. Kahn P. 1994 Zebrafish hit the big time. Science 264, 904-905. (doi:10.1126/science.8178149)
31. Teraoka H, Dong W, Hiraga T. 2003 Zebrafish as a novel experimental model for developmental toxicology. Congenit. Anom. (Kyoto) 43, 123-132. (doi:10.1111/j.1741-4520.2003.tb01036.x)
32. Zon LI, Peterson RT. 2005 In vivo drug discovery in the zebrafish. Nat. Rev. Drug Discov. 4, 35-44. (doi:10.1038/nrd1606)
33. Handley DA. 1989 Methods for synthesis of colloidal gold. In Colloid gold: principles, methods and applications (ed. MA Hayat), pp. 13-29. New York, NY: Academic Press.
34. Turkevich J, Stevenson PC, Hillier J. 1951 A study of the nucleation and growth processes in the synthesis of collodial gold. Discuss. Faraday Soc. 11, 55-75. (doi:10.1039/df9511100055)
35. Xu X-HN, Huang S, Brownlow W, Salatia K, Jeffers R. 2004 Size and temperature dependence of surface plasmon absorption of gold nanoparticles induced by tris(2,20-bipyridine)ruthenium(II). J. Phys. Chem. B 108, 15 543-15 551. (doi:10.1021/ jp048124b)
36. Huang T, Xu X-HN. 2010 Synthesis and characterization of tunable rainbow colored silver nanoparticle solutions using single-nanoparticle plasmonic microscopy and spectroscopy. J. Mater. Chem. 20, 9867-9876. (doi:10.1039/c0jm01990a)
37. Kusumi A, Sako Y. 1994 Compartmental structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis. J. Cell Biol. 125, 1251-1264. (doi:10.1083/jcb.125. 6.1251)
38. Kusumi A, Sako Y, Yamamoto M. 1993 Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells. Biophys. J. 65, 2021-2040. (doi:10. 1016/S0006-3495(93)81253-0)
39. Qian H, Sheetz MP, Elson EL. 1991 Single particle tracking. Analysis of diffusion and flow in twodimensional systems. Biophys. J. 60, 910-921. (doi:10.1016/S0006-3495(91)82125-7)
40. Tinoco I, Sauer K, Wang J, Puglisi JD. 2002 Physical chemistry-principles and applications in biological sciences, pp. 274-290. Englewood Cliffs, NJ: Prentice Hall.
41. Gebhart SC, Thompson RC, Mahadevan-Jansen A. 2007 Liquid-crystal tunable filter spectral imaging for brain tumor demarcation. Appl. Opt. 46, 1896-1910. (doi:10.1364/AO.46.001896)
42. Huang T, Cai W, Elsayed-Ali HE, Xu XHN. 2012 Highthroughput ultrasensitive characterization of chemical, structural and plasmonic properties of EBL-fabricated single silver nanoparticles. Nanoscale 4, 380-385. (doi:10.1039/c1nr11368b)
43. Westerfield M. 1993 The zebrafish book: a guide for the Laboratory use of zebrafish (Danio Rerio*), chs 1-4. Eugene, OR: University of Oregon Press. See http://zfin.org/zf_info/zfbook/zfbk.html.