메뉴 건너뛰기




Volumn 42, Issue 6, 2013, Pages 2103-2115

Contribution of the PI3K/MMPs/Ln-5γ2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas

Author keywords

3 dimensional matrix; Gallbladder neoplasm; Signaling pathway; Vasculogenic mimicry; Xenograft model

Indexed keywords

EPHRIN RECEPTOR A2; GELATINASE A; MATRIX METALLOPROTEINASE 14; PAXILLIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

EID: 84876514901     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1897     Document Type: Article
Times cited : (65)

References (56)
  • 3
    • 62549119553 scopus 로고    scopus 로고
    • Surgical management of gallbladder cancer
    • Reddy SK and Clary BM: Surgical management of gallbladder cancer. Surg Oncol Clin North Am 18: 307-324, 2009.
    • (2009) Surg Oncol Clin North Am , vol.18 , pp. 307-324
    • Reddy, S.K.1    Clary, B.M.2
  • 4
    • 0031437038 scopus 로고    scopus 로고
    • Research on characteristics of mortality spectrum and type composition of malignant tumors in China
    • Li LD, Zhang SW, Lu FZ, Mu R, Sun XD and Huangpu XM: Research on characteristics of mortality spectrum and type composition of malignant tumors in China. Zhonghua Zhongliu Zazhi 19: 323-328, 1997.
    • (1997) Zhonghua Zhongliu Zazhi , vol.19 , pp. 323-328
    • Li, L.D.1    Zhang, S.W.2    Lu, F.Z.3    Mu, R.4    Sun, X.D.5    Huangpu, X.M.6
  • 6
    • 62949113284 scopus 로고    scopus 로고
    • Factors infuencing long-term survival in patients with T3 gallbladder adenocarcinoma
    • Chakravarty KD, Yeh CN, Jan YY and Chen MF: Factors infuencing long-term survival in patients with T3 gallbladder adenocarcinoma. Digestion 79: 151-157, 2009.
    • (2009) Digestion , vol.79 , pp. 151-157
    • Chakravarty, K.D.1    Yeh, C.N.2    Jan, Y.Y.3    Chen, M.F.4
  • 8
    • 2342534955 scopus 로고    scopus 로고
    • Chemotherapy in the treatment of advanced gallbladder cancer
    • DOI 10.1159/000077440
    • Ishii H, Furuse J, Yonemoto N, Nagase M, Yoshino M and Sato T: Chemotherapy in the treatment of advanced gallbladder cancer. Oncology 66: 138-142, 2004. (Pubitemid 38608381)
    • (2004) Oncology , vol.66 , Issue.2 , pp. 138-142
    • Ishii, H.1    Furuse, J.2    Yonemoto, N.3    Nagase, M.4    Yoshino, M.5    Sato, T.6
  • 9
    • 67650021895 scopus 로고    scopus 로고
    • Treatment of patients with unresectable advanced carcinoma of biliary tract chemotherapy and surgical resection
    • Morise Z, Sugioka A, Tanahashi Y, Okabe Y, Ikeda M, Kagawa T and Takeura C: Treatment of patients with unresectable advanced carcinoma of biliary tract chemotherapy and surgical resection. Anticancer Res 29: 1783-1786, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 1783-1786
    • Morise, Z.1    Sugioka, A.2    Tanahashi, Y.3    Okabe, Y.4    Ikeda, M.5    Kagawa, T.6    Takeura, C.7
  • 11
    • 34347350058 scopus 로고    scopus 로고
    • Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease
    • DOI 10.1002/jso.20831
    • Mojica P, Smith D and Ellenhorn J: Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease. J Surg Oncol 96: 8-13, 2007. (Pubitemid 47015442)
    • (2007) Journal of Surgical Oncology , vol.96 , Issue.1 , pp. 8-13
    • Mojica, P.1    Smith, D.2    Ellenhorn, J.3
  • 12
    • 67650960677 scopus 로고    scopus 로고
    • Gallbladder cancer: We need to do better!
    • Shukla PJ and Barreto SG: Gallbladder cancer: we need to do better! Ann Surg Oncol 16: 2084-2085, 2009.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2084-2085
    • Shukla, P.J.1    Barreto, S.G.2
  • 16
    • 0037636378 scopus 로고    scopus 로고
    • The clinical signifcance of tumor cell-lined vasculature in ovarian carcinoma: Implications for anti-vasculogenic therapy
    • Sood AK, Fletcher MS, Zahn CM, Gruman LM, Coffn JE, Seftor EA and Hendrix MJ: The clinical signifcance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy. Cancer Biol Ther 1: 661-664, 2002.
    • (2002) Cancer Biol Ther , vol.1 , pp. 661-664
    • Sood, A.K.1    Fletcher, M.S.2    Zahn, C.M.3    Gruman, L.M.4    Coffn, J.E.5    Seftor, E.A.6    Hendrix, M.J.7
  • 17
    • 33947590737 scopus 로고    scopus 로고
    • Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma
    • Sun B, Zhang S, Zhang D, Du J, Guo H, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol Rep 16: 693-698, 2006.
    • (2006) Oncol Rep , vol.16 , pp. 693-698
    • Sun, B.1    Zhang, S.2    Zhang, D.3    Du, J.4    Guo, H.5    Zhao, X.6    Zhang, W.7    Hao, X.8
  • 21
    • 0042941848 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates membrane type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry
    • Hess AR, Seftor EA, Seftor R E and Hendrix MJ: Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res 63: 4757-4762, 2003. (Pubitemid 37022600)
    • (2003) Cancer Research , vol.63 , Issue.16 , pp. 4757-4762
    • Hess, A.R.1    Seftor, E.A.2    Seftor, R.E.B.3    Hendrix, M.J.C.4
  • 22
    • 0035417897 scopus 로고    scopus 로고
    • Cooperative interactions of laminin 5 γ2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma
    • Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, Bilban M, Stetler-Stevenson WG, Quaranta V and Hendrix MJ: Cooperative interactions of laminin 5 gamma 2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metallopro-teinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res 61: 6322-6327, 2001. (Pubitemid 32783230)
    • (2001) Cancer Research , vol.61 , Issue.17 , pp. 6322-6327
    • Seftor, R.E.B.1    Seftor, E.A.2    Koshikawa, N.3    Meltzer, P.S.4    Gardner, L.M.G.5    Bilban, M.6    Stetler-Stevenson, W.G.7    Quaranta, V.8    Hendrix, M.J.C.9
  • 23
    • 0013268010 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment with chemically modifed tetracyclines: Inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry
    • Seftor RE, Seftor EA, Kirschmann DA and Hendrix MJ: Targeting the tumor microenvironment with chemically modifed tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry. Mol Cancer Ther 1: 1173-1179, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1173-1179
    • Seftor, R.E.1    Seftor, E.A.2    Kirschmann, D.A.3    Hendrix, M.J.4
  • 27
    • 37249079132 scopus 로고    scopus 로고
    • Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: Role of the Eph receptors
    • DOI 10.1002/dvdy.21190
    • Hess AR, Margaryan N V, Seftor EA and Hendrix MJ: Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vascu-logenesis: role of the Eph receptors. Dev Dyn 236: 3283-3296, 2007. (Pubitemid 350276386)
    • (2007) Developmental Dynamics , vol.236 , Issue.12 , pp. 3283-3296
    • Hess, A.R.1    Margaryan, N.V.2    Seftor, E.A.3    Hendrix, M.J.C.4
  • 28
    • 33644782772 scopus 로고    scopus 로고
    • Focal adhesion kinase signaling and the aggressive melanoma phenotype
    • Hess AR and Hendrix MJ: Focal adhesion kinase signaling and the aggressive melanoma phenotype. Cell Cycle 5: 478-480, 2006. (Pubitemid 43340521)
    • (2006) Cell Cycle , vol.5 , Issue.5 , pp. 478-480
    • Hess, A.R.1    Hendrix, M.J.C.2
  • 32
    • 84891726886 scopus 로고    scopus 로고
    • Vasculogenic mimicry and its molecules signaling pathways
    • Ge CY and Fan YZ: Vasculogenic mimicry and its molecules signaling pathways. Chin Med Abstr (Surg) 15: 344-350, 2006.
    • (2006) Chin Med Abstr (Surg) , vol.15 , pp. 344-350
    • Ge, C.Y.1    Fan, Y.Z.2
  • 33
    • 79955534120 scopus 로고    scopus 로고
    • Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapy
    • Fan YZ and Sun W: Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapy. World J Gastrointest Surg 2: 117-127, 2010.
    • (2010) World J Gastrointest Surg , vol.2 , pp. 117-127
    • Fan, Y.Z.1    Sun, W.2
  • 34
    • 33947183331 scopus 로고    scopus 로고
    • Vasculogenic mimicry in human primary gallbladder carcinoma and clinical signifcance thereof
    • Fan YZ, Sun W, Zhang WZ and Ge CY: Vasculogenic mimicry in human primary gallbladder carcinoma and clinical signifcance thereof. Zhonghua Yi Xue Za Zhi 87: 145-149, 2007.
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , pp. 145-149
    • Fan, Y.Z.1    Sun, W.2    Zhang, W.Z.3    Ge, C.Y.4
  • 35
    • 84860778205 scopus 로고    scopus 로고
    • Overexpression of HIF-1α in primary gallbladder carcinoma and its relation to vasculogenic mimicry and unfavourable prognosis
    • Sun W, Shen ZY, Zhang H, Fan YZ, Zhang WZ, Zhang JT, Lu XS and Ye C: Overexpression of HIF-1α in primary gallbladder carcinoma and its relation to vasculogenic mimicry and unfavourable prognosis. Oncol Rep 27: 1990-2002, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 1990-2002
    • Sun, W.1    Shen, Z.Y.2    Zhang, H.3    Fan, Y.Z.4    Zhang, W.Z.5    Zhang, J.T.6    Lu, X.S.7    Ye, C.8
  • 36
    • 79955431026 scopus 로고    scopus 로고
    • A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro
    • Sun W, Fan YZ, Zhang WZ and Ge CY: A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro. J Exp Clin Cancer Res 30: 46, 2011.
    • J Exp Clin Cancer Res , vol.30 , Issue.46 , pp. 2011
    • Sun, W.1    Fan, Y.Z.2    Zhang, W.Z.3    Ge, C.Y.4
  • 37
    • 26244445559 scopus 로고    scopus 로고
    • Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt
    • DOI 10.1002/jcb.20479
    • Link W, Rosado A, Fominaya J, Thomas JE and Carnero A: Membrane localization of all class I PI3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fbroblasts via Akt. J Cell Biochem 95: 979-989, 2005. (Pubitemid 41420145)
    • (2005) Journal of Cellular Biochemistry , vol.95 , Issue.5 , pp. 979-989
    • Link, W.1    Rosado, A.2    Fominaya, J.3    Thomas, J.E.4    Carnero, A.5
  • 38
    • 0034176764 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Multifunctional contributors to tumor progression
    • DOI 10.1016/S1357-4310(00)01686-5, PII S1357431000016865
    • McCawley LJ and Matrisian LM: Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 6: 149-156, 2000. (Pubitemid 30171365)
    • (2000) Molecular Medicine Today , vol.6 , Issue.4 , pp. 149-156
    • McCawley, L.J.1    Matrisian, L.M.2
  • 40
    • 0033134622 scopus 로고    scopus 로고
    • Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
    • Stetler-Stevenson WG: Matrix metalloproteinases in angio-genesis: a moving target for therapeutic intervention. J Clin Invest 103: 1237-1241, 1999. (Pubitemid 29218293)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.9 , pp. 1237-1241
    • Stetler-Stevenson, W.G.1
  • 41
    • 0033003771 scopus 로고    scopus 로고
    • Membrane-type matrix metalloproteinases
    • Seiki M: Membrane-type matrix metalloproteinases. APMIS 107: 137-143, 1999. (Pubitemid 29133533)
    • (1999) APMIS , vol.107 , Issue.1 , pp. 137-143
    • Seiki, M.1
  • 42
    • 0035500490 scopus 로고    scopus 로고
    • The many faces of metalloproteases: Cell growth, invasion, angiogenesis and metastasis
    • Chang C and Werb Z: The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11: S37-S43, 2001.
    • (2001) Trends Cell Biol , vol.11
    • Chang, C.1    Werb, Z.2
  • 43
    • 0036712828 scopus 로고    scopus 로고
    • Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)
    • Lafleur, MA, Handsley MM, Knauper V, Murphy G and Edwards DR: Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). J Cell Sci 115: 3427-3438, 2002. (Pubitemid 34994032)
    • (2002) Journal of Cell Science , vol.115 , Issue.17 , pp. 3427-3438
    • Lefleur, M.A.1    Handsley, M.M.2    Knauper, V.3    Murphy, G.4    Edwards, D.R.5
  • 44
    • 0036022139 scopus 로고    scopus 로고
    • MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels
    • DOI 10.1002/jcb.10257
    • Koike T, Vernon RB, Hamner MA, Sadoun E and Reed MJ: MT1-MMP, but not secreted MMPs, infuences the migration of human microvascular endothelial cells in 3-dimensional collagen gels. J Cell Biochem 86: 748-758, 2002. (Pubitemid 34839976)
    • (2002) Journal of Cellular Biochemistry , vol.86 , Issue.4 , pp. 748-758
    • Koike, T.1    Vernon, R.B.2    Hamner, M.A.3    Sadoun, E.4    Reed, M.J.5
  • 45
    • 0032488895 scopus 로고    scopus 로고
    • Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells
    • DOI 10.1074/jbc.273.6.3604
    • Haas TL, Davis SJ and Madri JA: Three-dimensional type I collagen lattices induce coordinate expression of matrix metallo-proteinases MT1-MMP and MMP-2 inmicrovascular endothelial cells. J Biol Chem 273: 3604-3610, 1998. (Pubitemid 28109785)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.6 , pp. 3604-3610
    • Haas, T.L.1    Davis, S.J.2    Madri, J.A.3
  • 49
    • 0033785409 scopus 로고    scopus 로고
    • Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
    • Miao H, Burnett E, Kinch M, Simon E and Wang B: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2: 62-69, 2000.
    • (2000) Nat Cell Biol , vol.2 , pp. 62-69
    • Miao, H.1    Burnett, E.2    Kinch, M.3    Simon, E.4    Wang, B.5
  • 51
    • 33644645280 scopus 로고    scopus 로고
    • VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: Implications for vasculogenic mimicry
    • Hess AR, Seftor EA, Gruman LM, Kinch MS, Seftor RE and Hendrix MJ: VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry. Cancer Biol Ther 5: 228-233, 2006. (Pubitemid 43327544)
    • (2006) Cancer Biology and Therapy , vol.5 , Issue.2 , pp. 228-233
    • Hess, A.R.1    Seftor, E.A.2    Gruman, L.M.3    Kinch, M.S.4    Seftor, R.E.B.5    Hendrix, M.J.C.6
  • 52
    • 0035475321 scopus 로고    scopus 로고
    • Paxillin: A focal adhesion-associated adaptor protein
    • DOI 10.1038/sj.onc.1204786
    • Schaller MD: Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20: 6459-6472, 2001. (Pubitemid 32977851)
    • (2001) Oncogene , vol.20 , Issue.44 REV. ISS. 5 , pp. 6459-6472
    • Schaller, M.D.1
  • 53
    • 0024394212 scopus 로고
    • TIMP-2, a new member of the metalloproteinase inhibitor family
    • Stetler-Stevenson WG, Krutzsch HC and Liotta LA: TIMP-2, a new member of the metalloproteinase inhibitor family. J Biol Chem 264: 17374-17378, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 17374-17378
    • Stetler-Stevenson, W.G.1    Krutzsch, H.C.2    Liotta, L.A.3
  • 56
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: An imbalance of positive and negative regulation
    • Liotta LA and Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 51 (Suppl): S5054-S5059, 1991.
    • (1991) Cancer Res , vol.51 , Issue.SUPPL.
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.