Protective effect of melatonin on acute pancreatitis

International Journal of Inflammation

Volumn 2012, Issue , 2012, Pages

  Jaworek, Jolanta ^a   Szklarczyk, Joanna ^a   Jaworek, Andrzej K ^a   Nawrot Porabka, Katarzyna ^a   Leja Szpak, Anna ^a   Bonior, Joanna ^a   Kot, Michalina ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CHAPERONIN 60; GLUTATHIONE PEROXIDASE; INTERLEUKIN 10; MELATONIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL DEATH; CYTOKINE PRODUCTION; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; IMMUNOMODULATION; LIPID PEROXIDATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PANCREAS BLOOD FLOW; PINEAL BODY; PRIORITY JOURNAL; REVIEW; TISSUE REGENERATION;

EID: 84876510338     PISSN: 20908040     EISSN: 20420099     Source Type: Journal    
DOI: 10.1155/2012/173675     Document Type: Review

References (85)

1. Lerner A. B., Case J. D., Takahashi Y., Lee T. H., Mori W., Isolation of melatonin, the pineal gland factor that lightens melanocytes. Journal of the American Chemical Society 1958 80 10 2587 2-s2.0-33947460818
2. Berra B., Rizzo A. M., Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond. Clinics in Dermatology 2009 27 2 202 209 2-s2.0-58349119160 10.1016/j.clindermatol.2008.04.003
3. Esteban S., Garau C., Aparicio S., Moranta D., Barceló P., Fiol M. A., Rial R., Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. Journal of Pineal Research 2010 48 2 170 177 2-s2.0-75149124644 10.1111/j.1600-079X.2009.00741.x
4. Zawilska J. B., Skene D. J., Arendt J., Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacological Reports 2009 61 3 383 410 2-s2.0-67651151194
5. Bubenik G. A., gbubenik@uoguelph.ca Thirty four years since the discovery of gastrointestinal melatonin. Journal of Physiology and Pharmacology 2008 59 2, supplement 33 51
6. Chen C.-Q., Fichna J., Bashashati M., Li Y.-Y., Storr M., gidoc@gmx.com Distribution, function and physiological role of melatonin in the lower gut. World Journal of Gastroenterology 2011 17 34 3888 3898 10.3748/wjg.v17.i34.3888
7. Bubenik G. A., Pang S. F., Hacker R. R., Smith P. S., Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food. Journal of Pineal Research 1996 21 4 251 256 2-s2.0-0030281283 (Pubitemid 126733143)
8. Stefulj J., Hörtner M., Ghosh M., Schauenstein K., Rinner I., Wölfler A., Semmler J., Liebmann P. M., peter.liebmann@kfunigraz.ac.at Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. Journal of Pineal Research 2001 30 4 243 247 10.1034/j.1600-079X.2001. 300408.x (Pubitemid 32336907)
9. Shimozuma M., Tokuyama R., Tatehara S., Expression and cellular localization of melatonin-synthesis enzyme in rat and human salivary glands. Histochemistry and Cell Biology 2011 135 4 389 396
10. Huether G., Poeggeler B., Reimer A., George A., Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sciences 1992 51 12 945 953 2-s2.0-0026668767
11. Raikhlin N. T., Kvetnoy I. M., Tolkachev V. N., Melatonin may be synthesised in enterochromaffin cells. Nature 1975 255 5506 344 345 2-s2.0-0016808318
12. Kvetnoy I. M., Ingel I. E., Kvetnaia T. V., Malinovskaya N. K., Rapoport S. I., Raikhln N. T., Trofimov A. V., Yuzhakov V. V., Gastrointestinal melatonin: cellular identification and biological role. Neuroendocrinology Letters 2002 23 2 121 132 (Pubitemid 34495405)
13. Tan D. X., Manchester L. C., Reiter R. J., Qi W., Hanes M. A., Farley N. J., High physiological levels of melatonin in the bile of mammals. Life Sciences 1999 65 23 2523 2529 2-s2.0-0006128323 10.1016/S0024-3205(99)00519-6
14. Messner M., Huether G., Lorf T., Ramadori G., Schwörer H., Presence of melatonin in the human hepatobiliary-gastrointestinal tract. Life Sciences 2001 69 5 543 551 2-s2.0-0035933387 10.1016/S0024-3205(01)01143-2 (Pubitemid 32601981)
15. Bubenik G. A., Brown G. M., Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinial tract of rats. Biological Signals 1997 6 1 40 44 2-s2.0-0030951634 (Pubitemid 27135720)
16. Jaworek J., Leja-Szpak A., Bonior J., Nawrot K., Tomaszewska R., Stachura J., Sendur R., Pawlik W., Brzozowski T., Konturek S. J., Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion. Journal of Pineal Research 2003 34 1 40 52 2-s2.0-12244263456 10.1034/j.1600-079X.2003.02937.x (Pubitemid 36140357)
17. Jaworek J., mpjawore@cyf-kr.edu.pl Nawrot-Porabka K., Leja-Szpak A., Bonior J., Szklarczyk J., Kot M., Konturek S. J., Pawlik W. W., Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. Journal of Physiology and Pharmacology 2007 58 6, supplement 65 80
18. Stebelová K., Anttila K., katja.anttila@oulu.fi Mänttäri S., Saarela S., Zeman M., Immunohistochemical definition of MT2 receptors and melatonin in the gastrointestinal tissues of rat. Acta Histochemica 2010 112 1 26 33 10.1016/j.acthis.2008.03.004
19. Stebelová K., Herichová I., Zeman M., mzeman@fns.uniba.sk Diabetes induces changes in melatonin concentrations in peripheral tissues of rat. Neuroendocrinology Letters 2007 28 2 159 165 (Pubitemid 46744781)
20. Ramracheya R. D., Muller D. S., Squires P. E., Brereton H., Sugden D., Huang G. C., Amiel S. A., Jones P. M., Persaud S. J., Function and expression of melatonin receptors on human pancreatic islets. Journal of Pineal Research 2008 44 3 273 279 2-s2.0-40849142345 10.1111/j.1600-079X.2007.00523.x (Pubitemid 351392941)
21. Peschke E., Stumpf I., Bazwinsky I., Litvak L., Dralle H., Mühlbauer E., Melatonin and type 2 diabetesa possible link? Journal of Pineal Research 2007 42 4 350 358 2-s2.0-34147202423 10.1111/j.1600-079X.2007.00426.x (Pubitemid 46581659)
22. Langenberg C., Pascoe L., Mari A., Tura A., Laakso M., Frayling T. M., Barroso I., Loos R. J. F., Wareham N. J., Walker M., Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 2009 52 8 1537 1542 2-s2.0-67650694101 10.1007/s00125-009-1392-x
23. Picinato M. C., Hirata A. E., Cipolla-Neto J., Curi R., Carvalho C. R. O., Anhê G. F., Carpinelli A. R., Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets. Journal of Pineal Research 2008 44 1 88 94 2-s2.0-36849080350 10.1111/j.1600-079X.2007.00493.x (Pubitemid 350231100)
24. Mulder H., Nagorny C. L. F., Lyssenko V., Groop L., Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabetologia 2009 52 7 1240 1249 2-s2.0-67349224047 10.1007/s00125-009-1359-y
25. Jaworek J., Nawrot K., Konturek S. J., Leja-Szpak A., Thor P., Pawlik W. W., Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro. Journal of Pineal Research 2004 36 3 155 164 2-s2.0-1842453126 (Pubitemid 38429280)
26. Leja-Szpak A., Jaworek J., Nawrot-Porabka K., Palonek M., Mitis-Musio M., Dembiski A., Konturek S. J., Pawlik W. W., Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves. Journal of Physiology and Pharmacology 2004 55 33 46 2-s2.0-26044478330
27. Sletten T. L., Vincenzi S., Redman J. R., Lockley S. W., Rajaratnam S. M., Timing of sleep and its relationship with the endogenous melatonin rhythm. Frontiers in Neurology 2010 1 137 147
28. Chojnacki C., Wisniewska-Jarosiska M., Walecka-Kapica E., Klupiska G., Jaworek J., Chojnacki J., Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. Journal of Physiology and Pharmacology 2011 62 3 327 334
29. Ochoa J. J., jjoh@ugr.es Díaz-Castro J., Kajarabille N., García C., Guisado I. M., De Teresa C., Guisado R., Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. Journal of Pineal Research 2011 51 4 373 380 10.1111/j.1600-079X.2011.00899.x
30. Kurcer Z., Oguz E., Ozbilge H., Baba F., Aksoy N., Çelik H., Çakr H., Gezen M. R., Melatonin protects from ischemia/reperfusion- induced renal injury in rats: this effect is not mediated by proinflammatory cytokines. Journal of Pineal Research 2007 43 2 172 178 2-s2.0-34447534361 10.1111/j.1600-079X.2007.00459.x (Pubitemid 47077220)
31. Rodríguez M. I., Escames G., López L. C., López A., García J. A., Ortiz F., Acuña-Castroviejo D., dacuna@ugr.es Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice. Journal of Pineal Research 2007 42 3 272 279 10.1111/j.1600-079X.2006.00416.x (Pubitemid 46365065)
32. Ganguly K., Sharma A. V., Reiter R. J., Swarnakar S., Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. Journal of Pineal Research 2010 49 2 130 140 2-s2.0-77955159826 10.1111/j.1600-079X.2010.00776.x
33. Konturek S. J., Konturek P. C., Brzozowki T., Bubenik G., Role of melatonin in the upper gastrointestinal tract. Journal of Physiology and Pharmacology 2007 58 6, supplement 23 52
34. Miller S. C., Pandi P. S. R., Esquifino A. I., Cardinali D. P., Maestroni G. J. M., The role of melatonin in immuno-enhancement: potential application in cancer. International Journal of Experimental Pathology 2006 87 2 81 87 2-s2.0-33645333682 10.1111/j.0959-9673.2006.00474.x
35. Carrillo-Vico A., Reiter R. J., Lardone P. J., Herrera J. L., Fernández-Montesinos R., Guerrero J. M., Pozo D., The modulatory role of melatonin on immune responsiveness. Current Opinion in Investigational Drugs 2006 7 5 423 431 2-s2.0-33646831160 (Pubitemid 43772981)
36. Paredes S. D., Sánchez S., Parvez H., Rodríguez A. B., Barriga C., Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats. Neuroendocrinology Letters 2007 28 4 489 495 (Pubitemid 47577732)
37. Yang F. L., Subeq Y. M., Lee C. J., Lee R. P., Peng T. C., Hsu B. G., Melatonin Ameliorates Hemorrhagic Shock-Induced Organ Damage in Rats. Journal of Surgical Research 2011 167 3 15 21 2-s2.0-70449956693 10.1016/j.jss.2009.07.026
38. Terron M. P., Delgado J., Paredes S. D., Barriga C., Reiter R. J., Rodroguez A. B., Effect of melatonin and L-tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Experimental Gerontology 2009 44 10 653 658
39. Zhou W., Wang P., Tao L., Effect of melatonin on proliferation of neonatal cord blood mononuclear cells. World Journal of Pediatrics 2009 5 4 300 303 2-s2.0-73349105927 10.1007/s12519-009-0057-7
40. Mukherjee D., Roy S. G., Bandyopadhyay A., Chattopadhyay A., Basu A., Mitra E., Ghosh A. K., Reiter R. J., Bandyopadhyay D., Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. Journal of Pineal Research 2010 48 3 251 262 2-s2.0-77749310300 10.1111/j.1600-079X.2010.00749.x
41. Lin G. J., Huang S. H., Chen Y. W., Hueng D. Y., Chien M. W., Chia W. T., Chang D. M., Sytwu H. K., Melatonin prolongs islet graft survival in diabetic NOD mice. Journal of Pineal Research 2009 47 3 284 292 2-s2.0-69949125268 10.1111/j.1600-079X.2009.00712.x
42. Lahiri S., Singh P., Singh S., Rasheed N., Palit G., Pant K. K., Melatonin protects against experimental reflux esophagitis. Journal of Pineal Research 2009 46 2 207 213 2-s2.0-59149099772 10.1111/j.1600-079X.2008.00650.x
43. Miller E., Mrowicka M., Malinowska K., Kedziora J., Majsterek I., The effect of whole body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzyme in multiple sclerosis patients. Polski Merkuriusz Lekarski 2011 31 183 150 153
44. Shagirtha K., Muthumani M., Milton Prabu S., smprabu73@gmail.com Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. European Review for Medical and Pharmacological Sciences 2011 15 9 1039 1050
45. Tan D. X., Manchester L. C., Terron M. P., Flores L. J., Reiter R. J., One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? Journal of Pineal Research 2007 42 1 28 42 2-s2.0-33845536018 10.1111/j.1600-079X.2006.00407.x (Pubitemid 44924323)
46. Peyrot F., Ducrocq C., Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. Journal of Pineal Research 2008 45 3 235 246 2-s2.0-51649122293 10.1111/j.1600-079X.2008.00580.x
47. Reiter R. J., Paredes S. D., Korkmaz A., Joum J., Tan D. X., Melatonin combats molecular terrorism at the mitochondrial level. Interdisciplinary Toxicology 2008 1 137 148
48. Martínez-Cruz F., Osuna C., Guerrero J. M., Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C. Neuroscience Letters 2006 392 1-2 1 4 2-s2.0-28744448389 10.1016/j.neulet.2005.02.073 (Pubitemid 41757565)
49. Durante P., Romero F., Pérez M., Chávez M., Parra G., Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats. Toxicology and Industrial Health 2010 26 3 163 174 2-s2.0-77950485204 10.1177/0748233710362377
50. BergaminiI C. M., Gambetti S., Dondi A., Cervellaci C., Oxygen reactive species and tissue damage. Current Pharmaceutical Design 2004 10 1611 1626 (Pubitemid 38559774)
51. Gaecka E., Mrowicka M., Malinowska K., Gaecki P., Role of free radicals in the physiological processes. Polski Merkuriusz Lekarski 2008 24 143 446 448 2-s2.0-45749132282
52. Afonso V., Champy R., Mitrovic D., Collin P., Lomri A., Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine 2007 74 4 324 329 2-s2.0-34447328099 10.1016/j.jbspin.2007.02.002 (Pubitemid 47049827)
53. Shi C., Andersson R., Zhao X., Wang X., Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction. Pancreatology 2005 5 4-5 492 500 2-s2.0-23844450083 10.1159/000087063 (Pubitemid 41160293)
54. Modzelewski B., Janiak A., Lipid peroxidation product as prognostic factors in acute necrotizing pancreatitis. Polski Merkuriusz Lekarski 2005 19 112 511 513 2-s2.0-27644461940 (Pubitemid 41564455)
55. Reiter R. J., Tan D. X., Manchester L. C., Pilar Terron M., Flores L. J., Koppisepi S., Medical implications of melatonin: receptor-mediated and receptor-independent actions. Advances in medical sciences 2007 52 11 28 2-s2.0-39749108884
56. Jung K. H., Hong S. W., Zheng H. M., Lee H. S., Lee H., Lee D. H., Lee S. Y., Hong S. S., Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. Journal of Pineal Research 2010 48 3 239 250 2-s2.0-77749310344 10.1111/j.1600-079X.2010.00748.x
57. Sun X. F., Zhang H., NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histology and Histopathology 2007 22 12 1387 1398 (Pubitemid 47470331)
58. Czyz M., Specificity and selectivity of the NFkappaB response. Postepy Biochemii 2005 51 1 60 68 2-s2.0-33644649203
59. Chen H. M., Chen J. C., Ng C. J., Chiu D. F., Chen M. F., Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats. Journal of Pineal Research 2006 40 1 34 39 2-s2.0-33644907794 10.1111/j.1600-079X.2005.00271.x
60. Gülben K., kgulben@yahoo.com Özdemir H., Berberolu U., Mersin H., rkin F., Çakr E., Aksaray S., Melatonin modulates the severity of taurocholate-induced acute pancreatitis in the rat. Digestive Diseases and Sciences 2010 55 4 941 946 10.1007/s10620-009-0808-2
61. Muñoz-Casares F. C., Padillo F. J., med026014@saludalia.com Briceño J., Collado J. A., Muñoz-Castañeda J. R., Ortega R., Cruz A., Túnez I., Montilla P., Pera C., Muntané J., Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. Journal of Pineal Research 2006 40 3 195 203 10.1111/j.1600-079X.2005. 00291.x (Pubitemid 43344655)
62. Soybir G., Topuzlu C., Odabaş O., Dolay K., Bilir A., Köksoy F., The effects of melatonin on angiogenesis and wound healing. Surgery Today 2003 33 12 896 901 2-s2.0-0347416940 10.1007/s00595-003-2621-3 (Pubitemid 38037347)
63. Zhu H., Itoh K., Yamamoto M., Zweier J. L., Li Y., Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Letters 2005 579 14 3029 3036 2-s2.0-20444381360 10.1016/j.febslet.2005.04. 058 (Pubitemid 40797830)
64. Jockers R., Maurice P., Boutin J. A., Delagrange P., Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? British Journal of Pharmacology 2008 154 6 1182 1195 2-s2.0-47249088189 10.1038/bjp.2008.184 (Pubitemid 351992057)
65. Hardeland R., Melatonin: signaling mechanisms of a pleiotropic agent. BioFactors 2009 35 2 183 192 2-s2.0-67649236122 10.1002/biof.23
66. Costa E. J. X., Shida C. S., Biaggi M. H., Ito A. S., Lamy-Freund M. T., mtfreund@fge.if.usp.br How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies. FEBS Letters 1997 416 1 103 106 10.1016/S0014-5793(97)01178-2 (Pubitemid 27470811)
67. Bubenik G. A., gbubenik@uoguelph.ca Konturek S. J., Melatonin and aging: prospects for human treatment. Journal of Physiology and Pharmacology 2011 62 1 13 19
68. Qi W., Tan D. X., Reiter R. J., Kim S. J., Manchester L. C., Cabrera J., Sainz R. M., Mayo J. C., Melatonin reduces lipid peroxidation and tissue edema in cerulein- induced acute pancreatitis in rats. Digestive Diseases and Sciences 1999 44 11 2257 2262 2-s2.0-0032728487
69. Baykal A., Iskit A. B., Hamaloglu E., Oguz Guc M., Hascelik G., Sayek I., Melatonin modulates mesenteric blood flow and TNF α concentrations after lipopolysaccharide challenge. European Journal of Surgery 2000 166 9 722 727 2-s2.0-0033824459
70. Jaworek J., Konturek S. J., Leja-Szpak A., Nawrot K., Bonior J., Tomaszewska R., Stachura J., Pawlik W. W., Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat. Journal of Physiology and Pharmacology 2002 53 4 791 804 2-s2.0-0036916184 (Pubitemid 36014790)
71. Jaworek J., mpjawore@cyf-kr.edu.pl Zwirska-Korczala K., Szklarczyk J., Nawrot-Porabka K., Leja-Szpak A., Jaworek A. K., Tomaszewska R., Pinealectomy aggravates acute pancreatitis in the rat. Pharmacological Reports 2010 62 5 864 873
72. Szabolcs A., Reiter R. J., Letoha T., Hegyi P., Papai G., Varga I., Jarmay K., Kaszaki J., Sari R., Rakonczay Z., Lonovics J., Takacs T., Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. World Journal of Gastroenterology 2006 12 2 251 258 2-s2.0-33644760772 (Pubitemid 43336924)
73. Eşrefolu M., Gül M., Ateş B., Selimolu M. A., Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. Journal of Pineal Research 2006 40 1 92 97 2-s2.0-33644903543 10.1111/j.1600-079X.2005.00288.x
74. Jaworek J., Konturek S. J., Tomaszewska R., Leja-Szpak A., Bonior J., Nawrot K., Palonek M., Stachura J., Pawlik W. W., The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat. Journal of Pineal Research 2004 37 3 161 170 2-s2.0-4644336083 10.1111/j.1600-079X.2004.00153.x (Pubitemid 39274113)
75. Çöl C., Dinler K., Hasdemir A. O., Bugdayci G., The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. Journal of the Pancreas 2009 10 3 306 309 2-s2.0-68149162183
76. Sidhu S., sidhushabir@rediffmail.com Pandhi P., Malhotra S., Vaiphei K., Khanduja K. L., Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. European Journal of Pharmacology 2010 628 1-3 282 289 10.1016/j.ejphar.2009.11.058
77. Alhan E., alhan@meds.ktu.edu.tr Kalyoncu N. I., Kural B. V., Erçin C., Effects of melatonin on acute necrotizing pancreatitis in rats. Zeitschrift fur Gastroenterologie 2004 42 9 967 972 10.1055/s-2004-813321 (Pubitemid 39625603)
78. Belyaev O., Herzog T., Munding J., Bolik B., Vosschulte A., Uhl W., Müller C. A., Protective role of endogenous melatonin in the early course of human acute pancreatitis. Journal of Pineal Research 2011 50 1 71 77 2-s2.0-78650133062 10.1111/j.1600-079X.2010.00811.x
79. Jaworek J., Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity. Journal of Physiology and Pharmacology 2006 57 5 83 96 2-s2.0-34147168122 (Pubitemid 46569786)
80. Leja-Szpak A., Jaworek J., Pierzchalski P., Reiter R. J., Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). Journal of Pineal Research 2010 49 3 248 255 2-s2.0-77956301403 10.1111/j.1600-079X.2010.00789.x
81. Joly A. L., Wettstein G., Mignot G., Ghiringhelli F., Garrido C., Dual role of heat shock proteins as regulators of apoptosis and innate immunity. Journal of Innate Immunity 2010 2 3 238 247 2-s2.0-77953446392 10.1159/000296508
82. Bonior J., Jaworek J., Konturek S. J., Pawlik W. W., Increase of heat shock protein gene expression by melatonin in AR42J cells. Journal of Physiology and Pharmacology 2005 56 3 471 481 2-s2.0-26044479491 (Pubitemid 41406479)
83. Lissoni P., Is there a role for melatonin in supportive care? Supportive Care in Cancer 2002 10 2 110 116 2-s2.0-0036936925 10.1007/s005200100281 (Pubitemid 36056308)
84. Castro F., Carrizo E., Prieto de Rincón D., Rincón C. A., Asián T., Medina-Leendertz S., Bonilla E., Effectiveness of melatonin in tardive dyskinesia. Investigación clínica 2011 52 3 252 260
85. Cardinali D. P., Pagano E. S., Scacchi Bernasconi P. A., Reynoso R., Scacchi P., Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin. Neuroendocrinology Letters 2011 32 5 588 606