Lungs in heart failure

Pulmonary Medicine

Volumn , Issue , 2012, Pages

  Apostolo, Anna ^a   Giusti, Giuliano ^a   Gargiulo, Paola ^a,b   Bussotti, Maurizio ^c   Agostoni, Piergiuseppe ^a,d,e  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISOPROLOL; CARBON DIOXIDE; CARBON MONOXIDE; CARVEDILOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN; SURFACTANT PROTEIN B;

AIR CONDITIONING; ARTERIAL OXYGEN TENSION; BREATHING; BREATHING MECHANICS; CAPILLARY WALL; CARDIOMEGALY; CARDIOPULMONARY EXERCISE TEST; CARDIOPULMONARY HEMODYNAMICS; CENTRAL SLEEP APNEA SYNDROME; DISEASE SEVERITY; EMPHYSEMA; EXERCISE; EXERCISE TOLERANCE; EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; GAS EXCHANGE; HEART FAILURE; HUMAN; HYPERCAPNIA; HYPERVENTILATION; HYPOXIA; LUNG DIFFUSION; LUNG FLUID; LUNG FUNCTION; LUNG VASOCONSTRICTION; MULTICENTER STUDY (TOPIC); OXYGEN TRANSPORT; PRIORITY JOURNAL; PROGNOSIS; REST; REVIEW; SPIROMETRY; TIDAL VOLUME;

EID: 84876509242     PISSN: 20901836     EISSN: 20901844     Source Type: Journal    
DOI: 10.1155/2012/952741     Document Type: Review

References (79)

1. Rosca M. G., Hoppel C. L., Mitochondrial dysfunction in heart failure. Heart Failure Reviews. In press
2. Chua T. P., Coats A. J. S., The lungs in chronic heart failure. European Heart Journal 1995 16 7 882 887 2-s2.0-0029165766
3. Wright R. S., Levine M. S., Bellamy P. E., Simmons M. S., Batra P., Stevenson L. W., Walden J. A., Laks H., Tashkin D. P., Ventilatory and diffusion abnormalities in potential heart transplant recipients. Chest 1990 98 4 816 820 2-s2.0-0025038428 (Pubitemid 20355483)
4. Agostoni P., Cattadori G., Guazzi M., Palermo P., Bussotti M., Marenzi G., Cardiomegaly as a possible cause of lung dysfunction in patients with heart failure. American Heart Journal 2000 140 5, article e24 2-s2.0-0008053960 10.1067/mhj.2000.110282
5. Wasserman K., Zhang Y. Y., Gilt A., Belardinelli R., Koike A., Lubarsky L., Agostoni P. G., Lung function and exercise gas exchange in chronic heart failure. Circulation 1997 96 7 2221 2227 2-s2.0-0030823248 (Pubitemid 27425826)
6. Huang Y. C. T., Helms M. J., MacIntyre N. R., Normal values for single exhalation diffusing capacity and pulmonary capillary blood flow in sitting, supine positions, and during mild exercise. Chest 1994 105 2 501 508 2-s2.0-0028125779 (Pubitemid 24066725)
7. Roughton F. J., Forster R. E., Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. Journal of Applied Physiology 1957 11 2 290 302 2-s2.0-70449193465
8. Agostoni P., Bussotti M., Cattadori G., Margutti E., Contini M., Muratori M., Marenzi G., Fiorentini C., Gas diffusion and alveolar-capillary unit in chronic heart failure. European Heart Journal 2006 27 21 2538 2543 2-s2.0-33750305115 10.1093/eurheartj/ehl302 (Pubitemid 44627297)
9. Olson T. P., Beck K. C., Johnson B. D., Pulmonary function changes associated with cardiomegaly in chronic heart failure. Journal of Cardiac Failure 2007 13 2 100 107 2-s2.0-33947537239 10.1016/j.cardfail.2006.10.018 (Pubitemid 46467393)
10. Palermo P., Cattadori G., Bussotti M., Apostolo A., Contini M., Agostoni P., Lateral decubitus position generates discomfort and worsens lung function in chronic heart failure. Chest 2005 128 3 1511 1516 2-s2.0-24944479872 10.1378/chest.128.3.1511 (Pubitemid 41324440)
11. McCormack D. G., Increase in vital capacity after cardiac transplantation. The American Journal of Medicine 1991 90 5 660 661 2-s2.0-44949285224
12. Agostoni P., Pellegrino R., Conca C., Rodarte J. R., Brusasco V., Exercise hyperpnea in chronic heart failure: relationships to lung stiffness and expiratory flow limitation. Journal of Applied Physiology 2002 92 4 1409 1416 2-s2.0-0036092550 (Pubitemid 34670893)
13. Guazzi M., Alveolar gas diffusion abnormalities in heart failure. Journal of Cardiac Failure 2008 14 8 695 702 2-s2.0-52949091099 10.1016/j.cardfail. 2008.06.004
14. Naum C. C., Sciurba F. C., Rogers R. M., Pulmonary function abnormalities in chronic severe cardiomyopathy preceding cardiac transplantation. American Review of Respiratory Disease 1992 145 6 1334 1338 2-s2.0-0026871335
15. Siegel J. L., Miller A., Brown L. K., DeLuca A., Teirstein A. S., Pulmonary diffusing capacity in left ventricular dysfunction. Chest 1990 98 3 550 553 2-s2.0-0025018178 (Pubitemid 20352680)
16. Mettauer B., Lampert E., Charloux A., Zhao Q. M., Epailly E., Oswald M., Frans A., Piquard F., Lonsdorfer J., Lung membrane diffusing capacity, heart failure, and heart transplantation. American Journal of Cardiology 1999 83 1 62 67 2-s2.0-0032931169 10.1016/S0002-9149(98)00784-X (Pubitemid 29036649)
17. Agostoni P. G., Marenzi G. C., Pepi M., Doria E., Salvioni A., Perego G., Lauri G., Giraldi F., Grazi S., Guazzi M. D., Isolated ultrafiltration in moderate congestive heart failure. Journal of the American College of Cardiology 1993 21 2 424 431 2-s2.0-0027457391 (Pubitemid 23047927)
18. Puri S., Baker B. L., Dutka D. P., Oakley C. M., Hughes J. M. B., Cleland J. G. F., Reduced alveolar-capillary membrane diffusing capacity in chronic heart failure: its pathophysiological relevance and relationship to exercise performance. Circulation 1995 91 11 2769 2774 2-s2.0-0029054729
19. Al-Rawas O. A., Carter R., Stevenson R. D., Naik S. K., Wheatley D. J., Exercise intolerance following heart transplantation: the role of pulmonary diffusing capacity impairment. Chest 2000 118 6 1661 1670 2-s2.0-0034546678 10.1378/chest.118.6.1661 (Pubitemid 32001793)
20. Mutlu G. M., Factor P., Alveolar epithelial beta2-adrenergic receptors. American Journal of Respiratory Cell and Molecular Biology 2008 38 127 134
21. Guazzi M., Agostoni P., Bussotti M., Guazzi M. D., Impeded alveolar-capillary gas transfer with saline infusion in heart failure. Hypertension 1999 34 6 1202 1207 2-s2.0-0033405440 (Pubitemid 30002383)
22. Cattadori G., Wasserman K., Meloni C., Mustaq S., Contini M., Apostolo A., Andreini D., Magrì D., Sciomer S., Veglia F., Berna G., Introcaso G., Palermo P., Fiorentini C., Agostoni P., Alveolar membrane conductance decreases as BNP increases during exercise in heart failure. Rationale for BNP in the evaluation of dyspnea. Journal of Cardiac Failure 2009 15 2 136 144 2-s2.0-60849083539 10.1016/j.cardfail.2008.10.002
23. Agostoni P., Cattadori G., Bianchi M., Wasserman K., Exercise-induced pulmonary edema in heart failure. Circulation 2003 108 21 2666 2671 2-s2.0-0344844417 10.1161/01.CIR.0000097115.61309.59 (Pubitemid 37466809)
24. Pellegrino R., Dellacà R., Macklem P. T., Aliverti A., Bertini S., Lotti P., Agostoni P., Locatelli A., Brusasco V., Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans. Journal of Applied Physiology 2003 95 2 728 734 2-s2.0-0043130568 (Pubitemid 36944298)
25. Robertson H. T., Pellegrino R., Pini D., Oreglia J., DeVita S., Brusasco V., Agostoni P., Exercise response after rapid intravenous infusion of saline in healthy humans. Journal of Applied Physiology 2004 97 2 697 703 2-s2.0-3242680522 10.1152/japplphysiol.00108.2004 (Pubitemid 38963144)
26. Muir A. L., Flenley D. C., Kirby B. J., Cardiorespiratory effects of rapid saline infusion in normal man. Journal of Applied Physiology 1975 38 5 786 793 2-s2.0-0016749901
27. Agostoni P., Marenzi G., Lauri G., Perego G., Schianni M., Sganzerla P., Guazzi M. D., Sustained improvement in functional capacity after removal of body fluid with isolated ultrafiltration in chronic cardiac insufficiency: failure of furosemide to provide the same result. American Journal of Medicine 1994 96 3 191 199 2-s2.0-0028224424
28. Lalande S., Yerly P., Faoro V., Naeije R., Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals. Journal of Physiology 2012 590 17 4279 4288 10.1113/jphysiol.2012.234310
29. De Bisschop C., Martinot J.-B., Leurquin-Sterk G., Faoro V., Guénard H., Naeije R., Improvement in lung diffusion by endothelin A receptor blockade at high altitude. Journal of Applied Physiology 2012 112 1 20 25 10.1152/japplphysiol.00670.2011
30. Agostoni P. G., Bussotti M., Palermo P., Guazzi M., Does lung diffusion impairment affect exercise capacity in patients with heart failure? Heart 2002 88 5 453 459 2-s2.0-0036841446 (Pubitemid 35221951)
31. Abinader E. G., Sharif D. S., Goldhammer E., Effects of low altitude on exercise performance in patients with congestive heart failure after healing of acute myocardial infarction. American Journal of Cardiology 1999 83 3 383 387 2-s2.0-0033081885 10.1016/S0002-9149(98)00873-X (Pubitemid 29066498)
32. Guazzi M., Pontone G., Brambilla R., Agostoni P., Rèina G., Alveolar-capillary membrane gas conductance: a novel prognostic indicator in chronic heart failure. European Heart Journal 2002 23 6 467 476 2-s2.0-0036522191 10.1053/euhj.2001.2803 (Pubitemid 35204186)
33. De Pasquale C. G., Arnolda L. F., Doyle I. R., Grant R. L., Aylward P. E., Bersten A. D., Prolonged alveolocapillary barrier damage after acute cardiogenic pulmonary edema. Critical Care Medicine 2003 31 4 1060 1067 2-s2.0-0037387625 10.1097/01.CCM.0000059649.31659.22 (Pubitemid 36444414)
34. Magrì D., Brioschi M., Banfi C., Schmid J. P., Palermo P., Contini M., Apostolo A., Bussotti M., Tremoli E., Sciomer S., Cattadori G., Fiorentini C., Agostoni P., Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure. Circulation 2009 2 3 175 180 2-s2.0-72849145826 10.1161/CIRCHEARTFAILURE.108. 819607
35. Babb T. G., Viggiano R., Hurley B., Staats B., Rodarte J. R., Effect of mild-to-moderate airflow limitation on exercise capacity. Journal of Applied Physiology 1991 70 1 223 230 2-s2.0-0026025498
36. Johnson R. L. Jr., Gas exchange efficiency in congestive heart failure. Circulation 2000 101 24 2774 2776 2-s2.0-0034691242 (Pubitemid 30396005)
37. Johnson B. D., Beck K. C., Olson L. J., O'Malley K. A., Allison T. G., Squires R. W., Gau G. T., Ventilatory constraints during exercise in patients with chronic heart failure. Chest 2000 117 2 321 332 2-s2.0-0034001040 (Pubitemid 30111578)
38. O'Donnell D. E., Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society 2006 3 2 180 184 2-s2.0-33645526100 10.1513/pats.200508-093DO
39. Mancini D. M., Henson D., LaManca J., Levine S., Respiratory muscle function and dyspnea in patients with chronic congestive heart failure. Circulation 1992 86 3 909 918 2-s2.0-0026786739
40. Mancini D. M., Henson D., La Manca J., Donchez L., Levine S., Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Circulation 1995 91 2 320 329 2-s2.0-0028800735
41. Johnson B. D., Weisman I. M., Zeballos R. J., Beck K. C., Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop. Chest 1999 116 2 488 503 2-s2.0-0032791225 10.1378/chest.116.2.488 (Pubitemid 29382137)
42. Agostoni P. G., Cattadori G., Patterns of response diagnostic for cardiac disease. European Respiratory Monograph 2007 40 1 16
43. Bussotti M., Agostoni P., Durigato A., Santoriello C., Farina S., Brusasco V., Pellegrino R., Do maximum flow-volume loops collected during maximum exercise test alter the main cardiopulmonary parameters? Chest 2009 135 2 425 433 2-s2.0-60249103736 10.1378/chest.08-1477
44. Wasserman K., Hansen J. E., Sue D. Y., Principles of Exercise Testing and Interpretationed 1999 3rd Baltimore, Md, USA Lippincott Williams & Wilkins
45. 2 slope in chronic heart failure. European Journal of Cardiovascular Prevention and Rehabilitation 2003 10 4 267 272 2-s2.0-0242468761 10.1097/00149831-200308000-00008 (Pubitemid 37433491)
46. Johnson R. L. Jr., Gas exchange efficiency in congestive heart failure II. Circulation 2001 103 7 916 918 2-s2.0-0035916303
47. Wilcox I., Grunstein R. R., Collins F. L., Berthon-Jones M., Kelly D. T., Sullivan C. E., The role of central chemosensitivity in central apnea of heart failure. Sleep 1993 16 8 S37 S38 2-s2.0-0027738711 (Pubitemid 24054984)
48. Chua T. P., Clark A. L., Amadi A. A., Coats A. J. S., Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure. Journal of the American College of Cardiology 1996 27 3 650 657 2-s2.0-0029971287 10.1016/0735-1097(95)00523-4 (Pubitemid 26080387)
49. Chua T. P., Harrington D., Ponikowski P., Webb-Peploe K., Poole-Wilson P. A., Coats A. J. S., Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. Journal of the American College of Cardiology 1997 29 1 147 152 2-s2.0-0031022221 10.1016/S0735-1097(96) 00446-9 (Pubitemid 27028732)
50. Piepoli M., Clark A. L., Volterrani M., Adamopoulos S., Sleight P., Coats A. J. S., Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 1996 93 5 940 952 2-s2.0-0030003477 (Pubitemid 26074831)
51. Buller N. P., Poole-Wilson P. A., Mechanism of the increased ventilatory response to exercise in patients with chronic heart failure. British Heart Journal 1990 63 5 281 283 2-s2.0-0025283501 (Pubitemid 20187359)
52. Kleber F. X., Vietzke G., Wernecke K. D., Bauer U., Opitz C., Wensel R., Sperfeld A., Gläser S., Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 2000 101 24 2803 2809 2-s2.0-0034691301 (Pubitemid 30396010)
53. Paoletti P., De Filippis F., Fraioli F., Cinquanta A., Valli G., Laveneziana P., Vaccaro F., Martolini D., Palange P., Cardiopulmonary exercise testing (CPET) in pulmonary emphysema. Respiratory Physiology and Neurobiology 2011 179 2-3 167 173 10.1016/j.resp.2011.07.013
54. Agostoni P., Apostolo A., Sciomer S., Evolution of the concept of ventilatory limitation during exercise. Combining the pneumologist and cardiologist point of view. Respiratory Physiology and Neurobiology 2011 179 2-3 127 128 10.1016/j.resp.2011.09.002
55. Arena R., Myers J., Abella J., Peberdy M. A., Bensimhon D., Chase P., Guazzi M., Development of a ventilatory classification system in patients with heart failure. Circulation 2007 115 18 2410 2417 2-s2.0-34247159821 10.1161/CIRCULATIONAHA.107.686576 (Pubitemid 46717963)
56. Corrà U., Mezzani A., Bosimini E., Scapellato F., Imparato A., Giannuzzi P., Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity. American Heart Journal 2002 143 3 418 426 2-s2.0-0036189288 10.1067/mhj.2002. 120772 (Pubitemid 34185171)
57. 2 European Heart Journal 2000 21 2 154 161 2-s2.0-0033984879 (Pubitemid 30072630)
58. Gitt A. K., Wasserman K., Kilkowski C., Kleemann T., Kilkowski A., Bangert M., Schneider S., Schwarz A., Senges J., Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death. Circulation 2002 106 24 3079 3084 2-s2.0-0037058867 10.1161/01.CIR.0000041428.99427.06 (Pubitemid 35440292)
59. Guazzi M., De Vita S., Cardano P., Barlera S., Guazzi M. D., Normalization for peak oxygen uptake increases the prognostic power of the ventilatory response to exercise in patients with chronic heart failure. American Heart Journal 2003 146 3 542 548 2-s2.0-0042833221 10.1016/S0002- 8703(03)00321-1 (Pubitemid 37083092)
60. Ponikowski P., Francis D. P., Piepoli M. F., Davies L. C., Chua T. P., Davos C. H., Florea V., Banasiak W., Poole-Wilson P. A., Coats A. J. S., Anker S. D., Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation 2001 103 7 967 972 2-s2.0-0035916265 (Pubitemid 32183802)
61. Guazzi M., Myers J., Arena R., Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. Journal of the American College of Cardiology 2005 46 10 1883 1890 2-s2.0-27644449703 10.1016/j.jacc.2005.07.051 (Pubitemid 41579812)
62. Agostoni P., Guazzi M., Bussotti M., De Vita S., Palermo P., Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients. Chest 2002 122 6 2062 2067 2-s2.0-0036936261 10.1378/chest.122.6.2062 (Pubitemid 36054183)
63. 2 and exercise performance in healthy subjects. European Journal of Applied Physiology 2008 103 6 727 732 10.1007/s00421-008-0773-z
64. Guazzi M., Arena R., Ascione A., Piepoli M., Guazzi M. D., Exercise oscillatory breathing and increased ventilation to carbon dioxide production slope in heart failure: an unfavorable combination with high prognostic value. American Heart Journal 2007 153 5 859 867 2-s2.0-34247095100 10.1016/j.ahj.2007.02.034 (Pubitemid 46602158)
65. Baba R., Nagashima M., Goto M., Nagano Y., Yokota M., Tauchi N., Nishibata K., Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise. Journal of the American College of Cardiology 1996 28 6 1567 1572 2-s2.0-0030588919 10.1016/S0735-1097(96)00412-3 (Pubitemid 26391865)
66. Myers J., Arena R., Dewey F., Bensimhon D., Abella J., Hsu L., Chase P., Guazzi M., Peberdy M. A., A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure. American Heart Journal 2008 156 6 1177 1183 2-s2.0-56349097630 10.1016/j.ahj.2008.07.010
67. Davies L. C., Wensel R., Georgiadou P., Cicoira M., Coats A. J. S., Piepoli M. F., Francis D. P., Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope. European Heart Journal 2006 27 6 684 690 2-s2.0-33644889404 10.1093/eurheartj/ehi672
68. Sun X.-G., Hansen J. E., Stringer W. W., Oxygen uptake efficiency plateau best predicts early death in heart failure. Chest 2012 141 5 1284 1294 10.1378/chest.11-1270
69. Kremser C. B., O'Toole M. F., Leff A. R., Oscillatory hyperventilation in severe congestive heart failure secondary to idiopathic dilated cardiomyopathy or to ischemic cardiomyopathy. American Journal of Cardiology 1987 59 8 900 905 2-s2.0-0023260127 (Pubitemid 17061311)
70. Agostoni P., Apostolo A., Albert R. K., Mechanisms of periodic breathing during exercise in patients with chronic heart failure. Chest 2008 133 1 197 203 2-s2.0-38349023258 10.1378/chest.07-1439
71. Schmid J. P., Apostolo A., Antonioli L., Cattadori G., Zurek M., Contini M., Agostoni P., Influence of exertional oscillatory ventilation on exercise performance in heart failure. European Journal of Cardiovascular Prevention and Rehabilitation 2008 15 6 688 692 2-s2.0-64749098683 10.1097/HJR.0b013e32830fdfdb
72. Sun X. G., Hansen J. E., Beshai J. F., Wasserman K., Oscillatory breathing and exercise gas exchange abnormalities prognosticate early mortality and morbidity in heart failure. Journal of the American College of Cardiology 2010 55 17 1814 1823 2-s2.0-77950895258 10.1016/j.jacc.2009.10.075
73. Corrà U., Giordano A., Bosimini E., Mezzani A., Piepoli M., Coats A. J. S., Giannuzzi P., Oscillatory ventilation during exercise in patients with chronic heart failure: clinical correlates and prognostic implications. Chest 2002 121 5 1572 1580 2-s2.0-0036247731 10.1378/chest.121.5.1572 (Pubitemid 34499673)
74. Guazzi M., Marenzi G., Alimento M., Contini M., Agostoni P., Improvement of alveolar-capillary membrane diffusing capacity with enalapril in chronic heart failure and counteracting effect of aspirin. Circulation 1997 95 7 1930 1936 2-s2.0-0031001280 (Pubitemid 27164412)
75. Agostoni P., Magini A., Andreini D., Contini M., Apostolo A., Bussotti M., Cattadori G., Palermo P., Spironolactone improves lung diffussion in chronic heart failure. European Heart Journal 2005 26 2 159 164 2-s2.0-14144254868 10.1093/eurheartj/ehi023 (Pubitemid 40282784)
76. Agostoni P., Contini M., Cattadori G., Apostolo A., Sciomer S., Bussotti M., Palermo P., Fiorentini C., Lung function with carvedilol and bisoprolol in chronic heart failure: is β selectivity relevant? European Journal of Heart Failure 2007 9 8 827 833 2-s2.0-34547698952 10.1016/j.ejheart.2007.04.006 (Pubitemid 47212829)
77. Agostoni P., Apostolo A., Cattadori G., Salvioni E., Berna G., Antonioli L., Vignati C., Schina M., Sciomer S., Bussotti M., Palermo P., Fiorentini C., Contini M., Effects of β -blockers on ventilation efficiency in heart failure. American Heart Journal 2010 159 6 1067 1073 2-s2.0-77953062489 10.1016/j.ahj.2010.03.034
78. Agostoni P., Contini M., Magini A., Apostolo A., Cattadori G., Bussotti M., Veglia F., Andreini D., Palermo P., Carvedilol reduces exercise-induced hyperventilation: a benefit in normoxia and a problem with hypoxia. European Journal of Heart Failure 2006 8 7 729 735 2-s2.0-33750417152 10.1016/j.ejheart.2006.02.001 (Pubitemid 44637272)
79. Contini M., Paolillo S., Iorio A., Comparison of carvedilol, nebivolol and bisoprolol on cardiopulmonary function in moderate heart failure. European Heart Journal 2012 33 42 43