Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity

Diabetologia

Volumn 56, Issue 4, 2013, Pages 893-900

  Honka, H ^a,b   Makinen J ^a,b   Hannukainen, J C ^a   Tarkia, M ^a   Oikonen, V ^a   Teras M ^a   Fagerholm, V ^a   Ishizu, T ^a   Saraste, A ^a,b   Stark, C ^b,c   Vahasilta T ^b,c   Salminen, P ^b   Kirjavainen, A ^a   Soinio, M ^b   Gastaldelli, A ^d   Knuuti, J ^a   Iozzo, P ^d   Nuutila, P ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

Insulin action; Intermediary metabolism; Molecular imaging

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN; DIAGNOSTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; DIET RESTRICTION; DUODENUM; DYSLIPIDEMIA; EX VIVO STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; ILEUM; IN VIVO STUDY; INSULIN RESISTANCE; INTESTINE; INTESTINE MUCOSA; JEJUNUM; LEAN BODY WEIGHT; MORBID OBESITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SWINE; VALIDATION STUDY; ADULT; ANIMAL; ARTERY; FEMALE; GASTROINTESTINAL TRACT; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; RANDOMIZATION; VEIN;

ADULT; ANIMALS; ARTERIES; FEMALE; FLUORODEOXYGLUCOSE F18; GASTROINTESTINAL TRACT; GLUCOSE; HUMANS; INSULIN RESISTANCE; INTESTINES; MALE; MIDDLE AGED; OBESITY, MORBID; POSITRON-EMISSION TOMOGRAPHY; RANDOM ALLOCATION; SWINE; VEINS;

EID: 84876496304     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2825-5     Document Type: Article

References (29)

1. Delzenne N, Neyrinck A, Bäckhed F et al (2011) Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 7:639-646
2. Holst JJ, Vilsboll T, Deacon CF (2009) The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 297:127-136
3. Lin Y, Sun Z (2010) Current views on type 2 diabetes. J Endocrinol 204:1-11
4. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7
5. Ishizu K, Nishizawa S, Yonekura Y et al (1994) Effects of hyperglycemia on FDG uptake in human brain and glioma. J Nucl Med 35:1104-1109
6. Thie JA (1995) Clarification of a fractional uptake concept. J Nucl Med 36:711-712
7. Iozzo P, Jarvisalo MJ, Kiss J et al (2007) Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology 132:531-542
8. Teras M, Tolvanen T, Johansson JJ, Williams JJ, Knuuti J (2007) Performance of the new generation of whole-body PET/CT scanners: discovery STE and Discovery VCT. Eur J Nucl Med Mol Imaging 34:1683-1692
9. 18F] fluorodeoxyglucose in human skeletal muscle. J Nucl Med 40:1798-1804
10. Crane PD, Pardridge WM, Braun LD, Oldendorf WH (1983) Kinetics of transport and phosphorylation of 2-fluoro-2-deoxy-D-glucose in rat brain. J Neurochem 40:160-167
11. Bessell EM, Foster AB, Westwood JH (1972) The use of deoxyfluoro-D- glucopyranoses and related compounds in a study of yeast hexokinase specificity. Biochem J 128:199-204
12. DeGrado TR, Turkington TG, Williams JJ, Stearns CW, Hoffman JM, Coleman RE (1994) Performance characteristics of a whole-body PET scanner. J Nucl Med 35:1398-1406
13. 18F]fluoro-2-deoxy-D-glucose (FDG): a study on insulin action on FDG transport, uptake and metabolism in rat muscle, liver and adipose tissue. Life Sci 73:1437-1451
14. Virtanen KA, Peltoniemi P, Marjamaki P et al (2001) Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis. Diabetologia 44:2171-2179
15. del Prato S, Matsuda M, Simonson DC et al (1997) Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia 40:687-697
16. Mithieux G (2001) New data and concepts on glutamine and glucose metabolism in the gut. Curr Opin Clin Nutr Metab Care 4:267-271
17. Mithieux G (2012) A synergy between incretin effect and intestinal gluconeogenesis accounting for the rapid metabolic benefits of gastric bypass surgery. Curr Diab Rep 12:167-171
18. Croset M, Rajas F, Zitoun C et al (2001) Rat small intestine is an insulin-sensitive gluconeogenic organ. Diabetes 50:740-746
19. Rajas F, Bruni N, Montano S et al (1999) The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology 117:132-139
20. Mithieux G, Bady I, Gautier A et al (2003) Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes. Am J Physiol Endocrinol Metab 286:370-375
21. Mithieux G, Rajas F, Gautier-Stein A (2004) A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis. J Biol Chem 279:44231-44234
22. Barrett EJ, Ferrannini E, Gusberg R, Bevilacqua S, DeFronzo RA (1985) Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism 34:410-420
23. Tobin V, Le Gall M, Fioramonti X et al (2008) Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice. Diabetes 57:555-562
24. Ait-Omar A, Monteiro-Sepulveda M, Poitou C et al (2011) GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes 60:2598-2607
25. 18F-FDG bowel uptake in patients treated with metformin. Eur J Nucl Med Mol Imaging 35:95-99
26. Saraste A, Nekolla S, Schwaiger M (2009) Cardiovascular molecular imaging: an overview. Cardiovasc Res 83:643-652
27. Rinne J (1999) Drug development for neurodegenerative diseases: role of PET. Ann Med 31:444-449
28. Pendyala S, Walker JM, Holt PR (2012) A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142:1100-1101.e2
29. Ding S, Chi MM, Scull BP et al (2010) High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One 5:e12191