Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas

Human Pathology

Volumn 44, Issue 5, 2013, Pages 734-742

  O'Neal, Ryan L ^a,b   Nam, Ki Taek ^a,b   Lafleur, Bonnie J ^c   Barlow, Brittney ^a,b   Nozaki, Koji ^d   Lee, Hyuk Joon ^e   Kim, Woo Ho ^e   Yang, Han Kwang ^e   Shi, Chanjuan ^b,f   Maitra, Anirban ^f   Montgomery, Elizabeth ^f   Washington, M Kay ^b   El Rifai, Wael ^a,b   Drapkin, Ronny I ^g   Goldenring, James R ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e Seoul National University   (South Korea)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adenocarcinoma; HE4; Metaplasia; WFDC2

Indexed keywords

HUMAN EPIDIDYMIS PROTEIN 4;

ARTICLE; BARRETT ESOPHAGUS; CANCER SURVIVAL; DIGITAL IMAGING; ENDOCRINE CELL; ESOPHAGEAL ADENOCARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KOREA; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PANCREAS CANCER; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH CANCER; TISSUE MICROARRAY; UPREGULATION;

ADENOCARCINOMA; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; HUMANS; METAPLASIA; PANCREAS; PANCREATIC NEOPLASMS; PROTEINS; STOMACH; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84876490201     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.07.017     Document Type: Article

References (21)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. H.J. Lee, K.T. Nam, and H.S. Park Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer Gastroenterology 139 2010 213 225
3. K. Nozaki, M. Ogawa, and J.A. Williams A molecular signature of gastric metaplasia arising in response to acute parietal cell loss Gastroenterology 134 2008 511 521
4. L. Bingle, V. Singleton, and C.D. Bingle The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms Oncogene 21 2002 2768 2773 (Pubitemid 34478335)
5. R. Drapkin, H.H. von Horsten, and Y. Lin Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas Cancer Res 65 2005 2162 2169 (Pubitemid 40490123)
6. R.G. Moore, D.S. McMeekin, and A.K. Brown A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass Gynecol Oncol 112 2009 40 46
7. R.G. Moore, M.C. Miller, E.E. Eklund, K.H. Lu, R.C. Bast Jr., and G. Lambert-Messerlian Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age Am J Obstet Gynecol 206 2011 349.e1 349.e7
8. R.G. Moore, M.C. Miller, and M.M. Steinhoff Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders Am J Obstet Gynecol 206 2011 351.e351 351.e358
9. R.J. Schlemper, Y. Kato, and M. Stolte Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: proposal for a new classification system of gastrointestinal epithelial neoplasia J Gastroenterol Hepatol 15 Suppl 2000 G49 G57
10. T.W. Rice, V.W. Rusch, H. Ishwaran, and E.H. Blackstone Cancer of the esophagus and esophagogastric junction: data-driven staging for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer Cancer Staging Manuals Cancer 116 2010 3763 3773
11. C.M. Leys, S. Nomura, and B.J. LaFleur Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer Surgery 141 2007 41 50 (Pubitemid 44918077)
12. A. Maitra, N.V. Adsay, and P. Argani Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray Mod Pathol 16 2003 902 912 (Pubitemid 37152020)
13. D.Y. Lin, and L.J. Wei The robust inference for the proportional hazards model J Amer Statistical Assoc 84 1989 1074 1078
14. A. Clauss, V. Ng, and J. Liu Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival Neoplasia 12 2010 161 172
15. J.R. Goldenring, K.T. Nam, T.C. Wang, J.C. Mills, and N.A. Wright Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: Time for re-evaluation of metaplasias and the origins of gastric cancer Gastroenterolgy 139 2010 213 225
16. M. Reichert, and A.K. Rustgi Pancreatic ductal cells in development, regeneration, and neoplasia J Clin Invest 121 2011 4572 4578
17. A.L. Means, I.M. Meszoely, and K. Suzuki Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates Development 132 2005 3767 3776 (Pubitemid 41301112)
18. L. Zhu, G. Shi, C.M. Schmidt, R.H. Hruban, and S.F. Konieczny Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia Am J Pathol 171 2007 263 273 (Pubitemid 47339243)
19. J. Li, N. Abushahin, and S. Pang Tubal origin of 'ovarian' low-grade serous carcinoma Mod Pathol 24 2011 1488 1499
20. K. Levanon, C. Crum, and R. Drapkin New insights into the pathogenesis of serous ovarian cancer and its clinical impact J Clin Oncol 26 2008 5284 5293
21. K. Hamilton, A. Chiappori, S. Olson, J. Sawyers, D. Johnson, and K. Washington Prevalence and prognostic significance of neuroendocrine cells in esophageal adenocarcinoma Mod Pathol 13 2000 475 481 (Pubitemid 30332097)