Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population

Human Genetics

Volumn 132, Issue 4, 2013, Pages 423-429

  Sun, Jielin ^a   Tao, Sha ^a   Gao, Yong ^b,c   Peng, Tao ^b,d   Tan, Aihua ^c   Zhang, Haiying ^c   Yang, Xiaobo ^c   Qin, Xue ^b,c   Hu, Yanling ^c   Feng, Junjie ^a   Kim, Seong Tae ^a   Lin, Xiaoling ^e   Wu, Yongming ^b   Zhang, Ju ^f   Li, Zhixian ^c   Li, Li ^c   Mo, Linjian ^b   Liang, Zhengjia ^g   Shi, Deyi ^g   Huang, Zhang ^g   Huang, Xianghua ^h   Liu, Ming ⁱ   Liu, Qian ^b   Zhang, Shijun ^c   Lilly Zheng, S ^a   Xu, Jianfeng ^a,e,j   Mo, Zengnan ^b,c   more..

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

^d NATIONAL CANCER INSTITUTE   (United States)

^e FUDAN UNIVERSITY   (China)

^f NANKAI UNIVERSITY   (China)

^g Fangchenggang First People's Hospital   (China)

^h Guigang People's Hospital   (China)

ⁱ Yulin First People's Hospital   (China)

^j FUDAN UNIVERSITY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CHINA; CHINESE; CHROMOSOME 10Q; CHROMOSOME 11; CHROMOSOME 19Q; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; KLK3 GENE; MALE; MSMB GENE; NORMAL HUMAN; PHYSICAL EXAMINATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BLOOD LEVEL; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM; SLC45A3 GENE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CHROMOSOMES, HUMAN; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; KALLIKREINS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS;

EID: 84876467954     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-012-1254-3     Document Type: Article

References (17)

1. Bansal A, Murray DK, Wu JT, Stephenson RA, Middleton RG, Meikle AW (2000) Heritability of prostate-specific antigen and relationship with zonal prostate volumes in aging twins. J Clin Endocrinol Metab 85:1272-1276
2. Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy FC, Dearnaley DP, Muir KR, Smith C, Bagnato M, Ardern-Jones AT, Hall AL, O'Brien LT, Gehr-Swain BN, Wilkinson RA, Cox A, Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL, Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Fisher C, Jamieson C, Cooper CS, English DR, Hopper JL, Neal DE, Easton DF (2008) Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet 40:316-321. doi: 10.1038/ng.90
3. Gudmundsson J, Besenbacher S, Sulem P, Gudbjartsson DF, Olafsson I, Arinbjarnarson S, Agnarsson BA, Benediktsdottir KR, Isaksson HJ, Kostic JP, Gudjonsson SA, Stacey SN, Gylfason A, Sigurdsson A, Holm H, Bjornsdottir US, Eyjolfsson GI, Navarrete S, Fuertes F, Garcia-Prats MD, Polo E, Checherita IA, Jinga M, Badea P, Aben KK, Schalken JA, van Oort IM, Sweep FC, Helfand BT, Davis M, Donovan JL, Hamdy FC, Kristjansson K, Gulcher JR, Masson G, Kong A, Catalona WJ, Mayordomo JI, Geirsson G, Einarsson GV, Barkardottir RB, Jonsson E, Jinga V, Mates D, Kiemeney LA, Neal DE, Thorsteinsdottir U, Rafnar T, Stefansson K (2010) Genetic correction of PSA values using sequence variants associated with PSA levels. Sci Transl Med 2: 62ra92. doi: 10.1126/scitranslmed.3001513
4. Hernandez J, Thompson IM (2004) Prostate-specific antigen: a review of the validation of the most commonly used cancer biomarker. Cancer 101:894-904. doi: 10.1002/cncr.20480
5. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69-90. doi: 10.3322/caac.20107
6. Jian L, Xie LP, Lee AH, Binns CW (2004) Protective effect of green tea against prostate cancer: a case-control study in southeast China. Int J Cancer 108:130-135. doi: 10.1002/ijc.11550
7. Marchini J, Howie B, Myers S, McVean G, Donnelly P (2007) A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 39:906-913. doi: 10.1038/ng2088
8. Perner S, Rupp NJ, Braun M, Rubin MA, Moch H, Dietel M, Wernert N, Jung K, Stephan C, Kristiansen G (2012) Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course. Int J Cancer. doi: 10.1002/ijc.27733
9. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909. doi: 10.1038/ng1847
10. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575. doi: 10.1086/519795
11. Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Berenguer A, Maattanen L, Bangma CH, Aus G, Villers A, Rebillard X, van der Kwast T, Blijenberg BG, Moss SM, de Koning HJ, Auvinen A (2009) Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 360:1320-1328. doi: 10.1056/NEJMoa0810084
12. Shao Q, Ouyang J, Fan Y, Xie J, Zhou J, Wu J, Karim Kader A, Xu J, Liu G, Shan Y, Wen D, Zhang Y et al (2012) Prostate cancer in the senior men from rural areas in east district of China: contemporary management and 5-year outcomes at multi-institutional collaboration. Cancer Lett 315:170-177. doi: 10.1016/j.canlet.2011.09.035
13. Tan A, Gao Y, Yang X, Zhang H, Qin X, Mo L, Peng T, Xia N, Mo Z et al (2011) Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metab, Clin Exp 60:1186-1192. doi: 10.1016/j.metabol.2011.01.002
14. Thompson IM, Ankerst DP, Chi C, Lucia MS, Goodman PJ, Crowley JJ, Parnes HL, Coltman CA Jr (2005) Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower. JAMA 294:66-70. doi: 10.1001/jama.294.1.66
15. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (1999) Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. Genome Res 9:1198-1203
16. Xu J, Kalos M, Stolk JA, Zasloff EJ, Zhang X, Houghton RL, Filho AM, Nolasco M, Badaro R, Reed SG (2001) Identification and characterization of prostein, a novel prostate-specific protein. Cancer Res 61:1563-1568
17. Xu J, Mo Z, Ye D, Wang M, Liu F, Jin G, Xu C, Wang X, Shao Q, Chen Z, Tao Z, Qi J, Zhou F, Wang Z, Fu Y, He D, Wei Q, Guo J, Wu D, Gao X, Yuan J, Wang G, Xu Y, Yao H, Dong P, Jiao Y, Shen M, Yang J, Ou-Yang J, Jiang H, Zhu Y, Ren S, Zhang Z, Yin C, Dai B, Hu Z, Yang Y, Wu Q, Chen H, Peng P, Zheng Y, Zheng X, Xiang Y, Long J, Gong J, Na R, Lin X, Yu H, Tao S, Feng J, Sun J, Liu W, Hsing A, Rao J, Ding Q, Wiklund F, Gronberg H, Shu XO, Zheng W, Shen H, Jin L, Shi R, Lu D, Zhang X, Zheng SL, Sun Y (2012) Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet. doi: 10.1038/ng.2424