Semen abnormality and Nigerian herbal remedies: A preliminary investigation

Internet Journal of Toxicology

Volumn 8, Issue 2, 2011, Pages

  Enuh, Hilary ^a   Oragwu, Chikelue Ifeanyi ^b   Okeke, Chinedu ^b   Elu, Emmanuel ^b   Orisakwe, Orish Ebere ^c  

^a RICHMOND UNIVERSITY MEDICAL CENTER   (United States)

^b NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^c UNIVERSITY OF PORT HARCOURT   (Nigeria)

Author keywords

Herbal remedies; Male infertility; Reproductive health; Toxicity

Indexed keywords

ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EDUCATIONAL STATUS; HERBAL MEDICINE; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT PARAMETERS; MALE INFERTILITY; MEDICAL HISTORY; MEN'S HEALTH; NIGERIA; PROSPECTIVE STUDY; QUESTIONNAIRE; REPRODUCTIVE HEALTH; SEMEN ABNORMALITY; SEMEN ANALYSIS; SEMEN VOLUME; SOCIAL STATUS; SPERM QUALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TEACHING HOSPITAL;

EID: 84876465841     PISSN: None     EISSN: 15593916     Source Type: Journal    
DOI: 10.5580/2cba     Document Type: Article

References (53)

1. Gee BC, Wilson P, Morris AD, Emerson RM. Herbal is not synonymous with safe. Arch Dermatol 2002; 138: 1613.
2. Capasso R, Izzo AA, Pinto L, Bifulco T, Vitobello, Mascolo N. Phytotherapy and quality of herbal medicines. Fitoterapia 2000; 71: S58-S65.
3. Goldman P. Herbal medicines today and the roots of modern pharmacology. Ann Intern Med 2001; 135: 594-600.
4. Cohen MH. Regulation, religious experience, and epilepsy: a lens on complementary therapies. Epilepsy Behav 2003; 4: 602-606.
5. Topliss JG, Clark AM, Ernst E, Hufford CD, Johnson GAR, Rimoldi JM, Weimann BJ. Natural and synthetic substances related to human health. IUPAC Technical Report. Pure Appl Chem 2002; 74: 1957-1985.
6. Zini A, Fishcher MA, Nam RK, Jarvi K. Use of alternative and hormonal therapies in male infertility. Urology 2004; 63: 141-143.
7. Van Wassenhoven M, Ives G. An observational study of patients receiving homeopathic treatment. Homeopathy 2004; 93: 2-11.
8. Brunelli B, Gorson KC. The use of complementary and alternative medicines by patients with peripheral neuropathy. J Neurol Sci 2004; 218: 59-66.
9. Sharples FMC, van Haselen R, Fisher P. NHS patients' perspective on complementary medicine: a survey. Complement Ther Med 2003; 11: 243-248.
10. Smith JR, Spurrier NJ, Travis Martin J, Rosenbaum JT. Prevalent use of complementary and alternative medicine by patients with inflammatory eye disease. Ocul Immunol Inflamm 2004; 12: 203-214.
11. Orisakwe O.E., Dioka C. E., and Ofoefule S.I., (1996). A comparative review of poisoning in Nigeria. J. W. Afr. Pharm. 10 (2): 53-55.
12. Giwa-Osagie OO. Nigeria has twelve million infertile persons. Pharmanews 2003;25(7):48-49.
13. Cates W, Farley TMM, Rowe PJ. Worldwide patterns of infertility, is Africa different? Lancet 1985;2:596-598
14. Osegbe DN, Amaku EO. The causes of male infertility in 504 consecutive Nigeria patients. Int Urol Nephrol 1985;17:349.
15. Ikechebelu JI, Adinma JI, Orie EF, Ikegwuonu SO, 2003.High prevalence of male infertility in southeastern Nigeria Journal of Obstetrics and Gynaecology, 23(6):657-659.
16. WHO labpratory mannual for the examination of human semen and sperm cervical mucus interaction,4th edition, Cambridge university press, Cambridge.
17. World Health Organization, 1987. Infections, pregnancies, and infertility: perspectives on prevention. Fertil. Steril. 47, 964-968.
18. Brugo-Olmedo S, Chillik C, Kopelman S. Definition and causes of infertility. Reprod Biomed Online 2001; 2(1):41-53.
19. Sundby J. Methodological considerations in the study of frequency, risk factors and outcome of reduced fertility. Scand J Soc Med 1989; 17(2):135-140.
20. International workshop on the Impact of the Environment on Reproductive Health (1991: Copenhagen). Impact of the environment on reproductive health. Prog Hum Reprod Res 1991; 20:1-11.
21. Gerhard I, Monga B, Waldbrenner A, Runnebaum B. Heavy metals and fertility. J Toxicol Environ Health 1998; 54(8):593-611.
22. Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod 2001; 16(8):1768-1776.
23. Ulcova-Gallova Z. Diagnosis- infertility. Attack of antibodies. Praha: Petrklic; 1999. (In Czech)
24. Frank I, Bieger WP. Autoimunität bei Patienten mit zellulärer Sensibilisierung gegenu{double acute}ber Dentalmetallen. Immun Infekt 1997; 2:70-76. (In German)
25. Kosuda LL, Greiner DL, Bigazzi PE. Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone BB rats. Autoimmunity 1997; 26(3):173-187.
26. Pusey CD, Bowman C, Morgan A, Weetman AP, Hartley B, Lockwood CM. Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat. Clin Exp Immunol 1990; 81(1):76-82.
27. Kaminska T, Filar J, Madej E, Szuster-Ciesielska A, Kandefer-Szerszen M. Modification of bovine interferon and tumor necrosis factor production by lead in vivo and in vitro. Arch Immunol Ther Exp (Warsz.) 1998; 46(5):323-328.
28. O'Brian-Ladner AR, Nelson SR, Murphy WJ, Blumer BM, Wesselius LJ. Iron is a regulatory component of human IL-1 beta production. Support for regional variability in the lung. Am J Respir Cell Mol Biol 2000; 23(1):112-119.
29. Bostofte E, Serup J, Rebbe H. Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972. Int J Fertil 1983; 28(2):91-95.
30. Lawrence DA. Posited mechanisms of metal immunotoxicity. Hum Exp Toxicol. 1995; 14:114-116.
31. Bartova J, Prochazkova J, Kratka Z, Benetkova K, Vencliková Z, Sterzl I. Dental amalgam as a risk factor in autoimmune diseases. Neuroendocrinol Lett 2003; 24(1-2):65-67.
32. Bigazzi PE. Autoimmunity induced with metals. In: Chang LW, ed. Toxicology of metals. The USA: CRC Press, Inc 1996; 835-853.
33. Prochazkova J, Bartova J, Ivaskova E, Kupkova L, Sterzl I, Stejskal VDM. HLA - association in patients with intolerance to mercury and other metals in dental materials. Disease Markers 2000; 16:135-138.
34. Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, Haines CJ. Infertility, blood mercury concentrations and dietary seafood consumption. BJOG 2002; 109(10):1121-1125.
35. Hanf V, Forstmann A, Costea JE, Schieferstein G, Fischer I, Schweinsberg F. Mercury in urine and ejaculate in husbands of barren couples. Toxicol Lett 1996; 1-3:227-231.
36. Omu AE, Dashti H, Mohamed AT, Mattappallil AB. Significance of trace elements in seminal plasma of infertile men. Nutrition 1995; 11(5 Suppl):502-505.
37. Telisman S, Cvitkovic P, Jurasovic J, Pizent A, Gavella M, Rocic B. Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc and copper in men. Environ Health Perspect 2000; 108(1):45-53.
38. Bogusz MJ. (Ed). 2008. Forensic science. Hand book of Analytical separation,vol 6 Elsvier BV pg 589
39. Obi E., Akunyili D.N., Ekpo B.O., Orisakwe O.E. (2006). Heavy metals hazards of Nigerian Herbal Remedies. Sci Total Environ. 2006; 369(1-3): 35-41.
40. Davis LE, Wands JR, Weiss SA. Central nervous system intoxication from mercurous chloride laxatives. Arch Neurol 1974;30: 428-431.
41. Garvey JG, Gary H, Richard VL, Raymond DHC. Heavy metal hazards of Asian traditional remedies. Int J Environ Health Res 2001;11:63-71.
42. Koh HL, Woo SO. Chinese proprietary medicine in Singapore regulatory control of toxic heavy metals and undeclared drugs. Drug Safety 2000;23:351-362.
43. Schicher H. Contamination of natural products with pesticides and heavy metals. In: Breimer DD, Speiser P, editors. Topics in Pharmaceuticals Sciences. Amsterdam: Elsevier Science; 1983. p. 417-423.
44. Chaung IC, Chen KS, Huang YL, Lee PN, Lin TH. Determination of trace elements in some natural drugs by atomic absorption spectrometry. Biol Trace Elem Res 2000;76:235-244.
45. Oyejide CO, Oke ES. An ethnographic study of acute respiratory infections in four local government areas of Nigeria. Afr J Med Med Sci 1995;4(1):85-91.
46. WHO. Traditional medicine; 2003.
47. Obi, E., Heavy metal hazards of Nigerian herbal supplements: investigations into testicular toxicity in albino rats. Ph.D dissertation. Abia State University, Uturu, Abia State, Nigeria 2006.
48. Debem, H., Testicular toxicity of Operation Sweep M.Sc. dissertation. Usmanu Dan Fodio University Sokoto, Nigeria 2006.
49. Orisakwe OE, Debem HC, Etuk EU, Elsa AT (2010) Spermatoxic effects of operation sweep herbal supplement in male albino rats J Basic Clin Physiol Pharmacol.;21(2):147-156
50. Orisakwe OE, Afonne OJ, Dioka EC, Agbasi PU, Azikiwe C, Obi E. Testicular toxicity of rinbacin in rats. Biol Pharm Bull 2002;25 (2):206-208.
51. Orisakwe O E, Husaini D C, Afonne O J (2004) Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats
52. Ondrizek RR, Chan PJ, Patton WC, King A. Inhibition of human sperm motility by specific herbs used in alternative medicine. J Assist Reprod Genet 1999;16:87-91.
53. Ondrizek RR, Chan PJ, Patton WC, King A. An alternative medicine study of herbal. Fertil Steril 1999;71:517-522. Marks L, Partin AW, Epstein JI, et