Characterization of the relaxant response to taurine in rat corpus cavernosum

Pharmacology

Volumn 91, Issue 5-6, 2013, Pages 243-249

  Dalaklioglu Tasatargil, S ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Calcium; Corpus cavernosum; Potassium channels; Relaxation; Taurine

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BARIUM CHLORIDE; CALCIUM; GLIBENCLAMIDE; IBERIOTOXIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SILDENAFIL; TAURINE; TETRYLAMMONIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG POTENTIATION; ENDOTHELIUM; EXTRACELLULAR CALCIUM; INTRACELLULAR SIGNALING; MALE; MUSCLE RELAXATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION;

EID: 84876457775     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000348574     Document Type: Article

References (18)

1. Dashwood MR, Crump A, Shi-Wen X, Loesch A: Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally derived nitric oxide in erectile dysfunction. Curr Pharm Biotechnol 2011; 12: 1316-1321.
2. Lue TF: Erectile dysfunction. New Engl J Med 2000; 342: 1802-1813.
3. Vlachopoulos C, Rokkas K, Ioakeimidis N, Stefanadis C: Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. Eur Urol 2007; 52: 1590-1600.
4. Wespes E, Moreira de Goes P, Schulman CC: Vascular impotence: focal or diffuse penile disease. J Urol 1992; 148: 1435-1436.
5. Nunes KP, Labazi H, Webb RC: New insights into hypertension-associated erectile dysfunction. Curr Opin Nephrol Hypertens 2012; 21: 163-170.
6. Aversa A, Bruzziches R, Francomano D, Natali M, Gareri P, Spera G: Endothelial dysfunction and erectile dysfunction in the aging man. Int J Urol 2010; 17: 38-47.
7. Solomon H, Wierzbicki AS, Lumb PJ, Lambert- Hammill M, Jackson G: Cardiovascular risk factors determine erectile and arterial function response to sildenafil. Am J Hypertens 2006; 19: 915-919.
8. Stuckey BG, Walsh JP, Ching HL, Stuckey AW, Palmer NR, Thompson PL, Watts GF: Erectile dysfunction predicts generalised cardiovascular disease: evidence from a case-control study. Atherosclerosis 2007; 194: 458-464.
9. Malavige LS, Levy JC: Erectile dysfunction in diabetes mellitus. J Sex Med 2009; 6: 1232-1247.
10. Huxtable RJ: Physiological action of taurine. Physiol Rev 1992; 72: 101-163.
11. Li Z, Zhang M, Liang Y: Endothelium-independent vasorelaxant effect of taurine on rat aorta rings. Zhongguo Zhong Yao Za Zhi 2009; 34: 332-335.
12. Liu Y, Niu L, Zhang W, Cui L, Zhang X, Liang Y, Zhang M: Effects of taurine on contractions of the porcine coronary artery. Pharmacol Rep 2009; 61: 681-689.
13. Niu LG, Zhang MS, Liu Y, Xue WX, Liu DB, Zhang J, Liang YQ: Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur J Pharmacol 2008; 580: 169-174.
14. Han DH, Lee J, Kim H, Ko MK, Chae M, Kim HK, So I, Jeon JH, Park JK, Lee SW: Effects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca 2+ homeostasis in CSM cells. BJU Int 2012; 109: 1404-1413.
15. Ng CF, Koon CM, Cheung DW, Lam MY, Leung PC, Lau CB, Fung KP: The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation. J Ethnopharmacol 2011; 137: 1366-1372.
16. Berridge MJ, Irvine RF: Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312: 315-321.
17. Suematsu E, Hirata M, Hashimoto T, Kuriyama H: Inositol 1,4,5-trisphosphate releases Ca 2+ from intracellular store sites in skinned single cells of porcine coronary artery. Biochem Biophys Res Commun 1984; 120: 481-485.
18. Himpens B, Missiaen L, Casteels R: Ca 2+ homeostasis in vascular smooth muscle. J Vasc Res 1995; 32: 207-219.