Raphe obscurus neurons participate in thermoregulation in rats;Neurônios do núcleo obscuro da rafe participam da termorregulação em ratos

Arquivos de Neuro-Psiquiatria

Volumn 71, Issue 4, 2013, Pages 249-253

  Pires, José Guilherme Pinheiro ^b,c   Ulhoa, Melissa Araújo ^a   da Silva, Nyam Florencio ^a   de Azevedo Futuro Neto, Henrique ^a,b,d  

^a FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^b Centro Universitário do Espírito Santo ^*

^c Centro Universitário do Espírito Santo UNESC   (Brazil)

^d Escola Superior de Ciencias da Santa Casa de Misericordia de Vitoria   (Brazil)

Author keywords

Nucleus raphe obscurus; Serotonergic neurons; Serotonin

Indexed keywords

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTRODE; MALE; NONHUMAN; NUCLEUS RAPHE OBSCURUS; RAT; SENSORY STIMULATION; SEROTONINERGIC NERVE CELL; STEREOTACTIC PROCEDURE; TAIL; THERMOREGULATION;

EID: 84876423454     PISSN: 0004282X     EISSN: 16784227     Source Type: Journal    
DOI: 10.1590/0004-282X20130010     Document Type: Article

References (28)

1. Morrison SF. 2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: central neural pathways for thermoregulatory cold defense. J Appl Physiol 2011;110:1137-1149.
2. Gordon CJ. Thermal biology of the laboratory rat. Physiol Behav 1990;47:963-991.
3. Carlisle HJ, Laudenslager ML. Observations on the thermoregulatory effects of preoptic warming in rats. Physiol Behav 1979;23:723-732.
4. Kanosue K, Yanase-Fujiwara M, Honoso T. Hypothalamic network for thermoregulatory vasomotor control. Am J Physiol 1994;267(1 Pt 2):R283-288.
5. O'Leary DS, Johnson JM, Taylor WF. Mode of neural control mediating rat tail vasodilatation during heating. J Appl Physiol 1985;59:1533-1538.
6. Rathner JA, McAllen RM. Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups. Brain Res 1999;834:196-199.
7. Smith JE, Jansen AS, Gilbey MP, Loewy AD. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res 1998;786:153-164.
8. Coote JH, Futuro Neto HA, Logan SD. The involvement of serotonin neurones in the inhibition of renal nerve activity during desynchronized sleep. Brain Res 1985;340:277-284.
9. Taber E, Brodal A, Walberg F. The raphe nuclei of the brain stem in the cat. I. Normal topography and cytoarchitecture and general discussion. J Comp Neurol 1960;114:161-187.
10. Bowker RM, Abbott LC. Quantitative re-evaluation of descending serotonergic and non-serotonergic projections from the medulla of the rodent: evidence for extensive co-existence of serotonin and peptides in the same spinally projecting neurons, but not from the nucleus raphe magnus. Brain Res 1990;512:15-25.
11. Ray RS, Corcoran AE, Brust RD, et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 2011;333:637-642.
12. Berthoud HR, Patterson LM, Sutton GM, Morrison C, Zheng H. Inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 2005;123:147-156.
13. Morrison SF, Nakamura K. Central neural pathways for thermoregulation. Front Biosci 2011;16:74-104.
14. Nakamura K, Morrison SF. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2007;292:R127-136.
15. Smith JE, Jansen AS, Gilbey MP, Loewy AD. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res 1998;786:153-164.
16. Tanaka M, Nagashima K, McAllen RM, Kanosue K. Role of the medullary raphé in thermoregulatory vasomotor control in rats. J Physiol 2002;540:657-664.
17. Tanaka M, Ootsuka Y, McKinley MJ, McAllen RM. Independent vasomotor control of rat tail and proximal hairy skin. J Physiol 2007;582:421-433.
18. Nakamura K, Matsumura K, Hübschle T, et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci 2004;24:5370-5380.
19. Ootsuka Y, Blessing WW, McAllen RM. Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries. Neurosci Lett 2004;357:58-62.
20. Ootsuka Y, Blessing WW. Inhibition of medullary raphé/parapyramidal neurons prevents cutaneous vasoconstriction elicited by alerting stimuli and by cold exposure in conscious rabbits. Brain Res 2005;1051:189-193.
21. Ootsuka Y, McAllen RM. Interactive drives from two brain stem premotor nuclei are essential to support rat tail sympathetic activity. Am J Physiol Regul Integr Comp Physiol 2005;289:R1107-1115.
22. Futuro-Neto HA, Coote JH. Changes in sympathetic activity to heart and blood vessels during desynchronized sleep. Brain Res 1982;252:259-268.
23. Dantas MA, Có W, Futuro-Neto HA. Responses of neurons of the nucleus raphe obscurus to noxious stimuli. Braz J Med Biol Res 1990;23:923-926.
24. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 6th ed. San Diego: Elsevier, 2007. p. 1-166.
25. Futuro Neto HA, Dantas MA, Gilbey MP. A comparison of the effects of eserine sulfate on the activity of medullary raphe neurons in the anesthetized rabbit and rat. Braz J Med Biol Res 1994;27:1445-1454.
26. Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev 1992;72:165-229.
27. Chéry-Croze S. Painful sensation induced by a thermal cutaneous stimulus. Pain 1983;17:109-137.
28. Sternbach H. The serotonin syndrome. Am J Psychiatry 1991;148:705-713.