Resistance in Escherichia coli: Variable contribution of efflux pumps with respect to different fluoroquinolones

Journal of Applied Microbiology

Volumn 114, Issue 5, 2013, Pages 1294-1299

  Huguet, A ^a   Pensec, J ^a   Soumet, C ^a  

^a FRENCH AGENCY FOR FOOD   (France)

Author keywords

Efflux pump; Escherichia coli; Fluoroquinolones; Hydrophobicity; Resistance

Indexed keywords

ANTIBIOTICS; ANTIMICROBIAL AGENTS; ESCHERICHIA COLI; GENE EXPRESSION;

AFTER-TREATMENT; DIFFERENT MECHANISMS; E. COLI; EFFLUX PUMP INHIBITORS; EFFLUX PUMPS; EXPRESSION LEVELS; EXPRESSION PROFILE; FLUOROQUINOLONES; MARBOFLOXACIN; RESISTANCE;

HYDROPHOBICITY;

CIPROFLOXACIN; ENROFLOXACIN; MARBOFLOXACIN; PORIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTICS; COLIFORM BACTERIUM; HYDROPHOBICITY; INHIBITOR; NODULATION;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; EFFUSION; ESCHERICHIA COLI; GENE EXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE;

ESCHERICHIA COLI;

EID: 84876417726     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/jam.12156     Document Type: Article

References (25)

1. Bohnert, J.A., Schuster, S., Fahnrich, E., Trittler, R. and Kern, W.V. (2007) Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). J Antimicrob Chemother 59, 1216-1222.
2. Cattoir, V. (2004) Efflux-mediated antibiotics resistance in bacteria. Pathol Biol (Paris) 52, 607-616.
3. Clinical and Laboratory Standards Institute (2008) Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standards. CLSI Document M31-A3, 3rd edn. Wayne, PA: Clinical and Laboratory Standards Institute.
4. Cohen, S.P., Hooper, D.C., Wolfson, J.S., Souza, K.S., McMurry, L.M. and Levy, S.B. (1988) Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob Agents Chemother 32, 1187-1191.
5. Cohen, S.P., McMurry, L.M., Hooper, D.C., Wolfson, J.S. and Levy, S.B. (1989) Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction. Antimicrob Agents Chemother 33, 1318-1325.
6. Edgar, R. and Bibi, E. (1997) MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J Bacteriol 179, 2274-2280.
7. Fabrega, A., Martin, R.G., Rosner, J.L., Tavio, M.M. and Vila, J. (2010) Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Antimicrob Agents Chemother 54, 1218-1225.
8. Gibson, J.S., Cobbold, R.N., Kyaw-Tanner, M.T., Heisig, P. and Trott, D.J. (2010) Fluoroquinolone resistance mechanisms in multidrug-resistant Escherichia coli isolated from extraintestinal infections in dogs. Vet Microbiol 146, 161-166.
9. Hooper, D.C. (2001) Emerging mechanisms of fluoroquinolone resistance. Emerg Infect Dis 7, 337-341.
10. Hopkins, K.L., Davies, R.H. and Threlfall, E.J. (2005) Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. Int J Antimicrob Agents 25, 358-373.
11. Jellen-Ritter, A.S. and Kern, W.V. (2001) Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone. Antimicrob Agents Chemother 45, 1467-1472.
12. Kern, W.V., Steinke, P., Schumacher, A., Schuster, S., von Baum, H. and Bohnert, J.A. (2006) Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J Antimicrob Chemother 57, 339-343.
13. Mazzariol, A., Tokue, Y., Kanegawa, T.M., Cornaglia, G. and Nikaido, H. (2000) High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA. Antimicrob Agents Chemother 44, 3441-3443.
14. Morgan-Linnell, S.K., Becnel Boyd, L., Steffen, D. and Zechiedrich, L. (2009) Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother 53, 235-241.
15. Morita, Y., Kodama, K., Shiota, S., Mine, T., Kataoka, A., Mizushima, T. and Tsuchiya, T. (1998) NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother 42, 1778-1782.
16. Poole, K. (2000) Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrob Agents Chemother 44, 2233-2241.
17. Poole, K. (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56, 20-51.
18. Saenz, Y., Ruiz, J., Zarazaga, M., Teixido, M., Torres, C. and Vila, J. (2004) Effect of the efflux pump inhibitor Phe-Arg-beta-naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin. J Antimicrob Chemother 53, 544-545.
19. Swick, M.C., Morgan-Linnell, S.K., Carlson, K.M. and Zechiedrich, L. (2011) Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrob Agents Chemother 55, 921-924.
20. Tavio, M.M., Vila, J., Ruiz, J., Martin-Sanchez, A.M. and Jimenez de Anta, M.T. (1999) Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates. J Antimicrob Chemother 44, 735-742.
21. Tavio, M.M., Aquili, V.D., Poveda, J.B., Antunes, N.T., Sanchez-Cespedes, J. and Vila, J. (2010) Quorum-sensing regulator sdiA and marA overexpression is involved in in vitro-selected multidrug resistance of Escherichia coli. J Antimicrob Chemother 65, 1178-1186.
22. Teresa Tejedor, M., Martin, J.L., Navia, M., Freixes, J. and Vila, J. (2003) Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections. Vet Microbiol 94, 295-301.
23. Webber, M. and Piddock, L.J. (2001) Quinolone resistance in Escherichia coli. Vet Res 32, 275-284.
24. Yang, S., Clayton, S.R. and Zechiedrich, E.L. (2003) Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli. J Antimicrob Chemother 51, 545-556.
25. Yasufuku, T., Shigemura, K., Shirakawa, T., Matsumoto, M., Nakano, Y., Tanaka, K., Arakawa, S., Kinoshita, S. et al. (2011) Correlation of overexpression of efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients. J Clin Microbiol 49, 189-194.