Biomarkers identified with time-lapse imaging: Discovery, validation, and practical application

Fertility and Sterility

Volumn 99, Issue 4, 2013, Pages 1035-1043

  Chen, Alice A ^a   Tan, Lei ^a   Suraj, Vaishali ^a   Reijo Pera, Renee ^b   Shen, Shehua ^a  

^a Auxogyn Inc   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; embryo selection; noninvasive; prediction; time lapse imaging

Indexed keywords

ACCURACY; BLASTOCYST; CLINICAL PRACTICE; COMPUTER PROGRAM; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; EMBRYOLOGY; FERTILIZATION; FERTILIZATION IN VITRO; HUMAN; IMAGE ANALYSIS; INTRACYTOPLASMIC SPERM INJECTION; LABORATORY AUTOMATION; MITOSIS; MULTIPLE PREGNANCY; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK REDUCTION; SEMEN ANALYSIS; TIME LAPSE IMAGING; VALIDATION PROCESS;

BIOLOGICAL MARKERS; BLASTOCYST; FEMALE; FERTILIZATION IN VITRO; HUMANS; PREGNANCY; REPRODUCIBILITY OF RESULTS; SINGLE EMBRYO TRANSFER; TIME-LAPSE IMAGING;

EID: 84876363261     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.01.143     Document Type: Conference Paper

References (44)

1. A.P. van Montfoort, J.C. Dumoulin, J.A. Land, E. Coonen, J.G. Derhaag, and J.L. Evers Elective single embryo transfer (eSET) policy in the first three IVF/ICSI treatment cycles Hum Reprod 20 2005 433 436
2. D. Payne, S.P. Flaherty, M.F. Barry, and C.D. Matthews Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography Hum Reprod 12 1997 532 541
3. J.G. Lemmen, I. Agerholm, and S. Ziebe Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes Reprod Biomed Online 17 2008 385 391
4. C. Pribenszky, S. Matyas, P. Kovacs, E. Losonczi, J. Zadori, and G. Vajta Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring Reprod Biomed Online 21 2010 533 536
5. C. Wong, K. Loewke, N. Bossert, B. Behr, C. De Jonge, and T. Baer Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Nat Biotechnol 28 2010 1115 1121
6. M. Meseguer, J. Herrero, A. Tejera, K.M. Hilligsoe, N.B. Ramsing, and J. Remohi The use of morphokinetics as a predictor of embryo implantation Hum Reprod 26 2011 2658 2671
7. S. Hashimoto, N. Kato, K. Saeki, and Y. Morimoto Selection of high-potential embryos by culture in poly(dimethylsiloxane) microwells and time-lapse imaging Fertil Steril 97 2012 332 337
8. 2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection Fertil Steril 97 2012 742 747
9. M. Cruz, N. Garrido, J. Herrero, I. Perez-Cano, M. Munoz, and M. Meseguer Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality Reprod Biomed Online 25 2012 371 381
10. D. Hlinka, B. Kalatova, I. Uhrinova, S. Dolinska, J. Rutarova, and J. Rezacova Time-lapse cleavage rating predicts human embryo viability Physiol Res 61 2012 513 525
11. M. Dal Canto, G. Coticchio, M. Mignini Renzini, E. De Ponti, P.V. Novara, and F. Brambillasca Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation Reprod Biomed Online 25 2012 474 480
12. I. Rubio, R. Kuhlmann, I. Agerholm, J. Kirk, J. Herrero, and M.-J. Escribá Limited implantation success of direct-cleaved human zygotes: a time-lapse study Fertil Steril 98 2012 1458 1463
13. A. Azzarello, T. Hoest, and A.L. Mikkelsen The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture Hum Reprod 27 2012 2649 2657
14. S.L. Chavez, K.E. Loewke, J. Han, F. Moussavi, P. Colls, and S. Munne Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage Nat Commun 3 2012 1251
15. Y. Mio, and K. Maeda Time-lapse cinematography of dynamic changes occurring during in vitro development of human embryos Am J Obstet Gynecol 199 2008 660.e1 660.e5
16. R. Brown, and J. Harper The clinical benefit and safety of current and future assisted reproductive technology Reprod Biomed Online 25 2012 108 117
17. J. Harper, M. Cristina Magli, K. Lundin, C.L.R. Barratt, and D. Brison When and how should new technology be introduced into the IVF laboratory? Hum Reprod 27 2012 303 313
18. S.S. Palmer, and K.T. Barnhart Biomarkers in reproductive medicine: the promise, and can it be fulfilled? Fertil Steril 13 2012 02431 02434
19. A. Ajduk, T. Ilozue, S. Windsor, Y. Yu, K.B. Seres, and R.J. Bomphrey Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability Nat Commun 9 2011 417
20. K. Piotrowska, F. Wianny, R.A. Pedersen, and M. Zernicka-Goetz Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development Development 128 2001 3739 3748
21. L.M. Ottosen, J. Hindkjær, and J. Ingerslev Light exposure of the ovum and preimplantation embryo during ART procedures J Assist ReprodGenet 24 2007 99 103
22. T. Nakahara, A. Iwase, M. Goto, T. Harata, M. Suzuki, and M. Ienaga Evaluation of the safety of time-lapse observations for human embryos J Assist Reprod Genet 27 2010 93 96
23. K. Kirkegaard, J.J. Hindkjaer, M.L. Grondahl, U.S. Kesmodel, and H.J. Ingerslev A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator J Assist Reprod Genet 29 2012 565 572
24. M. Cruz, B. Gadea, N. Garrido, K.S. Pedersen, M. Martinez, and I. Perez-Cano Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging J Assist Reprod Genet 28 2011 569 573
25. M. Meseguer, I. Rubio, M. Cruz, N. Basile, J. Marcos, and A. Requena Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study Fertil Steril 98 2012 1481 1489.e10
26. A.A. Chen, K. Ivani, J. Conaghan, M. Gvakharia, A. Le, and S. Shen Improved embryo selection accuracy using cell division characteristics defined by time-lapse and automated image analysis Fertil Steril 98 Suppl 2012 S17
27. S. Shen, A.A. Chen, S.P. Willman, P.E. Chenette, R. Boostanfar, and V.L. Baker Early cell cycle durations detected by time-lapse imaging predict embryo developmental potential Hum Reprod 27 2012 ii22 ii24
28. M. Meseguer, J. Herrero, A. Tejera, S. Perez, K.M. Hilligsøe, and M.J. De los Santos Preliminary evaluation of an embryo quality classification system based in a multivariate analysis of morphokinetic data from time-lapse Fertil Steril 96 2011 S244
29. E.G. Papanikolaou, E. D'Haeseleer, G. Verheyen, H. Van de Velde, M. Camus, and A. Van Steirteghem Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study Hum Reprod 20 2005 3198 3203
30. E.G. Papanikolaou, M. Camus, E.M. Kolibianakis, L. Van Landuyt, A. Van Steirteghem, and P. Devroey In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos N Engl J Med 354 2006 1139 1146
31. D.A. Blake, C.M. Farquhar, N. Johnson, and M. Proctor Cleavage stage versus blastocyst stage embryo transfer in assisted conception Cochrane Database Syst Rev 4 2007 CD002118
32. B. Kallen, O. Finnstrom, A. Lindam, E. Nilsson, K.G. Nygren, and P.O. Olausson Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome? Fertil Steril 94 2010 1680 1683
33. S.K. Kalra, S.J. Ratcliffe, K.T. Barnhart, and C. Coutifaris Extended Embryo Culture and an Increased Risk of Preterm Delivery Obstetrics & Gynecology 120 2012 69 75 10.1097/AOG.0b013e31825b88fc
34. M.P. Diamond, S. Willman, P. Chenette, and M.I. Cedars The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles J Assist Reprod Genet 29 2012 391 396
35. T. Hardarson, C. Lofman, G. Coull, A. Sjogren, L. Hamberger, and R.G. Edwards Internalization of cellular fragments in a human embryo: time-lapse recordings Reprod Biomed Online 5 2002 36 38
36. G. Vajta, T.T. Peura, P. Holm, A. Paldi, T. Greve, and A.O. Trounson New method for culture of zona-included or zona-free embryos: the Well of the Well (WOW) system Mol Reprod Dev 55 2000 256 264
37. S.-J. Dai, C.-L. Xu, J. Wang, Y.-P. Sun, and R.-C. Chian Effect of culture medium volume and embryo density on early mouse embryonic development: Tracking the development of the individual embryo J Assist Reprod Genet 29 2012 617 623
38. A.E. Baxter Bendus, J.F. Mayer, S.K. Shipley, and W.H. Catherino Interobserver and intraobserver variation in day 3 embryo grading Fertil Steril 86 2006 1608 1615
39. G. Danuser Computer vision in cell biology Cell 147 2011 973 978
40. T. Abaigar, M. Cano, A.R. Pickard, and W.V. Holt Use of computer-assisted sperm motility assessment and multivariate pattern analysis to characterize ejaculate quality in Mohor gazelles (Gazella dama mhorr): effects of body weight, electroejaculation technique and short-term semen storage Reproduction 122 2001 265 273
41. W. Krause, and G. Viethen Quality assessment of computer-assisted semen analysis (CASA) in the andrology laboratory Andrologia 31 1999 125 129
42. B. Dziura, S. Quinn, and K. Richard Performance of an imaging system vs. manual screening in the detection of squamous intraepithelial lesions of the uterine cervix Acta Cytol 50 2006 309 311
43. R. Lozano Comparison of computer-assisted and manual screening of cervical cytology Gynecol Oncol 104 2007 134 138
44. K. Loewke, F. Moussavi, M. Maddah, K. Ivani, B. Behr, and V. Suraj Development and validation of an automated computer vision algorithm for real-time embryo viability prediction Fertil Steril 98 Suppl 2012 S288 S289