Development of a sensitive and rapid UPLC-MS/MS method for the determination of koumine in rat plasma: Application to a pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 6, 2013, Pages 736-740

  Chen, Jian Zhong ^a   Li, Yu ^a   Xiao, Jian Ping ^b   Wu, Shui Sheng ^a   Song, Heng Wen ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Internal Medicine of Second People's Hospital of Fujian Province   (China)

Author keywords

Determination; Koumine; Pharmacokinetics; UPLC MS MS

Indexed keywords

BODY FLUIDS; FORMIC ACID; METHANOL; QUALITY CONTROL; RATS;

DETERMINATION; KOUMINE; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTEIN PRECIPITATION; RAPID METHOD; RAT PLASMA; SAMPLE PREPARATION TECHNIQUES; SENSITIVE METHOD; UPLC-MS/MS;

PHARMACOKINETICS;

KOUMINE;

ANIMAL TISSUE; ARTICLE; CHROMATOGRAPHY; DRUG CLEARANCE; DRUG DETERMINATION; ELECTROSPRAY; FEMALE; FOOD AND DRUG ADMINISTRATION; IN VIVO STUDY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MEAN RESIDENCE TIME; NONHUMAN; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

RATTUS;

EID: 84876332374     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2852     Document Type: Article

References (13)

1. Cai J, Wang WS, Lei LS and Chi DB. An experimental study on anti-stress effect of koumine on mice. Journal of Guangzhou University of Traditional Chinese Medicine 2007; 24: 317-319.
2. Cai J, Lei LS and Chi DB. Antineoplastic effect of koumine in mice bearing H22 solid tumor. Journal of Southern Medical University 2009; 29: 1851-1852.
3. Chi DB, Li L, Sun LS and Ma WF. Koumine-induced apoptosis of human colonic adenocarcinoma cells: the cell biological mechanism. Journal of Southern Medical University 2007; 27: 994-997.
4. Dutt V, Thakur S, Dhar VJ and Sharma A. The genus Gelsemium: an update. Pharmacognosy Review 2010; 4: 185-194.
5. Editorial Committee of Chinese Materia Medica; the Administration Bureau of Traditional Chinese Medicine. Chinese Materia Medica (Zhonghua Bencao), Vol. 6. Shanghai Science and Technology: Shanghai, 2000; 213-215.
6. Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, May 2001. Available from: http://www.fda.gov/CVM.
7. Lu JM, Qi ZR, Liu GL, Shen ZY and Tu KC. Effect of Gelsemium elegans Benth. injection on proliferation of tumor cells. Chinese Journal of Cancer 1990; 9: 472-477.
8. Wang WS, Xue X, Wang DA and Chi DB. Growth-inhibiting and apoptosis-inducing effects of Kou on human glioma cell line U251. Journal of the Fourth Military Medical University 2009; 30: 2914-2917.
9. Xie LJ and Han XF. Mechanism, clinical characteristics and management of Gelsemium elegans poisoning. Adverse Drug Reactions Journal 2006; 8: 202-204.
10. Xu KY, Tan JQ and Shen FM. A study on anti-inflammatory effect of Gelsemium elegans Benth. Pharmacology Clinics of Chinese Materia Medica 1991; 7: 27-28.
11. Xu Y, Qiu HQ, Liu H, Liu M, Huang ZY, Yang J, Su YP and Yu CX. Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone. Pharmacology Biochemistry and Behavior 2012a; 101: 504-514.
12. Xu YK, Liao SG, Na Z, Hu HB, Li Y and Luo HR. Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans. Fitoterapia 2012b; 83: 1120-1124.
13. Yamada Y, Kitajima M, Koqure N, Wongseripipatana S and Takayama H. Seven new monoterpenoid indole alkaloids from Gelsemium elegans. Chemistry, an Asian Journal 2011; 6: 166-173.