Effect of Azithromycin on Anticoagulation-Related Outcomes in Geriatric Patients Receiving Warfarin

Clinical Therapeutics

Volumn 35, Issue 4, 2013, Pages 425-430

  Mergenhagen, Kari A ^a   Olbrych, Pamela M ^b   Mattappallil, Arun ^a   Krajewski, Michael P ^c   Ott, Michael C ^d  

^a VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

^b WJB Dorn VA Medical Center   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d ERIE COUNTY MEDICAL CENTER   (United States)

Author keywords

Azithromycin; Older adults; Warfarin

Indexed keywords

AZITHROMYCIN; WARFARIN;

AGED; ANTICOAGULATION; ARTICLE; BLEEDING; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; DEEP VEIN THROMBOSIS; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG HALF LIFE; EAR INFECTION; FOOT DISEASE; GERIATRIC PATIENT; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HUMAN; INTERNATIONAL NORMALIZED RATIO; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MITRAL VALVE REGURGITATION; SKIN INFECTION; SOFT TISSUE INFECTION; THROMBOSIS; TOOTH INFECTION; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; AZITHROMYCIN; HUMANS; RETROSPECTIVE STUDIES; WARFARIN;

EID: 84876314790     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2013.02.012     Document Type: Article

References (28)

1. Slaughter R.L., Edwards D.J. Recent advances: the cytochrome P450 enzymes. Ann Pharmacother 1995, 29:619-624.
2. Hassell D., Utt J.K. Suspected interaction: warfarin and erythromycin. South Med J 1985, 78:1015-1016.
3. Oberg K.C. Delayed elevation of international normalized ratio with concurrent clarithromycin and warfarin therapy. Pharmacotherapy 1998, 18:386-391.
4. Recker M.W., Kier K.L. Potential interaction between clarithromycin and warfarin. Ann Pharmacother 1997, 31:996-998.
5. Weibert R.T., Lorentz S.M., Townsend R.J., et al. Effect of erythromycin in patients receiving long-term warfarin therapy. Clin Pharm 1989, 8:210-214.
6. Foster D.R., Milan N.L. Potential interaction between azithromycin and warfarin. Pharmacotherapy 1999, 19:902-908.
7. Woldtvedt B.R., Cahoon C.L., Bradley L.A., Miller S.J. Possible increased anticoagulation effect of warfarin induced by azithromycin. Ann Pharmacother 1998, 32:269-270.
8. Shrader S.P., Fermo J.D., Dzikowski A.L. Azithromycin and warfarin interaction. Pharmacotherapy 2004, 24:945-949.
9. Wiese M.D. Raised INR with concurrent warfarin and azithromycin. Aust J Hosp Pharm 1999, 29:159-161.
10. McCall K.L., Anderson H.G., Jones A.D. Determination of the lack of a drug interaction between azithromycin and warfarin. Pharmacotherapy 2004, 24:188-194.
11. Beckey N.P., Parra D., Colon A. Retrospective evaluation of a potential interaction between azithromycine and warfarin in patients stabilized on warfarin. Pharmacotherapy 2000, 20:1055-1059.
12. Hopkins S. Clinical toleration and safety of azithromycin. Am J Med 1991, 91:40S-45S.
13. DRUG-REAX system, Accessed February 9, 2013. http://www.thomsonhc.com.
14. Drug-drug interactions. Facts & Comparisons Accessed February 9, 2013. http://www.factsandcomparisons.com.
15. Lexicomp interactions Accessed February 9, 2013. http://www.lexi.com.
16. Drug-drug interactions report. Clinical Pharmacology Accessed February 9, 2013. http://www.clinicalpharmacology.com.
17. Schentag J.J., Ballow C.H. Tissue-directed pharmacokinetics. Am J Med 1991, 91:5S-11S.
18. Bhat R.V., Deshmukh C.T. A study of Vitamin K status in children on prolonged antibiotic therapy. Indian Pediatr 2003, 40:36-40.
19. Hirsh J., Dalen J., Anderson D.R., et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 2001, 119:8S-21S.
20. Shirakawa H., Komai M., Kimura S. Antibiotic-induced vitamin K deficiency and the role of the presence of intestinal flora. Int J Vitam Nutr Res 1990, 60:245-251.
21. Cordes I., Buchmann S., Scheffner D. Vitamin K deficiency with erythromycin: observation of a boy treated with valproate [in German]. Monatsschr Kinderheilkd 1990, 138:85-87.
22. Stork C.M., Marraffa J.M., Ragosta K., et al. Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy. Am J Health Syst Pharm 2011, 68:1012-1014.
23. Shorr R.I., Ray W.A., Daugherty J.R., Griffin M.R. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993, 153:1665-1670.
24. Chan T.Y.K. Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance. Ann Pharmacother 1995, 29:1274-1283.
25. Hazlewood K.A., Fugate S.E., Harrison D.L. Effect of oral corticosteroids on chronic warfarin therapy. Ann Pharmacother 2006, 40:2101-2106.
26. Rao K.B., Pallaki M., Tolbert S.R., Hornick T.R. Enhanced hypoprothrombinemia with warfarin due to azithromycin. Ann Pharmacother 2004, 38:982-985.
27. Westphal J.F. Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. Br J Clin Pharmacol 2000, 50:285-295.
28. Peters D.H., Friedel H.A., McTavish D. Azithromycin: a review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs 1992, 44:750-799.