Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy

American Journal of Health-System Pharmacy

Volumn 68, Issue 11, 2011, Pages 1012-1014

  Stork, Christine M ^a   Marraffa, Jeanna M ^b   Ragosta, Kevin ^b   Wojcik, Susan M ^b   Angelino, Kenneth L ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Azithromycin; Blood coagulation disorders; Cerebral palsy; Drugs, adverse reactions; International normalized ratio; Macrolides; Pediatrics; Phytonadione; Vitamins

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; AMYLASE; ASPARTATE AMINOTRANSFERASE; AZITHROMYCIN; BILIRUBIN; BUDESONIDE; CARNITINE; CELECOXIB; CLONAZEPAM; FOLIC ACID; HYDROCORTISONE; LANSOPRAZOLE; LEVALBUTEROL; MONTELUKAST; ONDANSETRON; OXYGEN; PHYTOMENADIONE; SENNA EXTRACT; TIZANIDINE; TRIACYLGLYCEROL LIPASE; VALPROIC ACID;

ADRENAL INSUFFICIENCY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMMONIA BLOOD LEVEL; AMYLASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASE REPORT; CEREBRAL PALSY; CHILD; CORTICOSTEROID THERAPY; DRUG WITHDRAWAL; EMERGENCY WARD; GALLSTONE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LONG TERM CARE; MALE; MEDICAL HISTORY; OXYGEN SATURATION; PANCREATITIS; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESTLESSNESS; SCHOOL CHILD; SIDE EFFECT; SINGLE DRUG DOSE; SPASTICITY; TRIACYLGLYCEROL LIPASE BLOOD LEVEL;

EID: 79958274333     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp100603     Document Type: Article

References (19)

1. Ansell JE, Kumar R, Deykin D. The spectrum of vitamin K deficiency. JAMA. 1977; 238:40-2.
2. Durie PR. Vitamin K and the management of patients with cystic fibrosis. CMAJ. 1994; 151:933-6.
3. Mosler K, von Kries R, Vermeer C et al. Assessment of vitamin K deficiency in CF - how much sophistication is useful? J Cyst Fibros. 2003; 2:91-6.
4. Verghese T, Beverley D. Vitamin K deficient bleeding in cystic fibrosis. Arch Dis Child. 2003; 88:553.
5. Grammatikopoulou MG, Daskalou E, Tsigga M. Diet, feeding practices, and anthropometry of children and adolescents with cerebral palsy and their siblings. Nutrition. 2009; 25:620-6.
6. Cordes I, Buchmann S, Scheffner D. Vitamin K deficiency with erythromycin. Observation of a boy treated with valproate. Monatsschr Kinderheilkd. 1990; 138:85-7. Abstract.
7. Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30:239-45.
8. Conly J, Stein K. Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials. Clin Invest Med. 1994; 17:531-9.
9. Shirakawa H, Komai M, Kimura S. Antibiotic-induced vitamin K deficiency and the role of the presence of intestinal flora. Int J Vitam Nutr Res. 1990; 60:245-51.
10. Matsubara T, Touchi A, Harauchi T et al. Depression of liver microsomal vitamin K epoxide reductase activity associated with antibiotic-induced coagulopathy. Biochem Pharmacol. 1989; 38:2693-701.
11. Bhat RV, Deshmukh CT. A study of vitamin K status in children on prolonged antibiotic therapy. Indian Pediatr. 2003; 40:36-40.
12. Yoshikawa H, Yamazaki S, Watanabe T et al. Vitamin K deficiency in severely disabled children. J Child Neurol. 2003; 18:93-7.
13. Acharya S, Bussel JB. Hematologic toxicity of sodium valproate. J Pediatr Hematol Oncol. 2000; 22:62-5.
14. Gerstner T, Teich M, Bell N et al. Valproate-associated coagulopathies are frequent and variable in children. Epilepsia. 2006; 47:1136-43.
15. Sussman NM, McLain LW Jr. A direct hepatotoxic effect of valproic acid. JAMA. 1979; 242:1173-4.
16. Isbister GK, Dawson A, Isbister JP. Recommendations for the management of over-anticoagulation with warfarin. Emerg Med. 2001; 13:469-72.
17. Sarin S, Mukhtar H, Mirza MA. Prolonged coagulopathy related to superwarfarin overdose. Ann Intern Med. 2005; 142:156.
18. Amsden GW. Anti-inflammatory effects of macrolides - an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother. 2005; 55:10-21.
19. Ianaro A, Ialenti A, Maffia P et al. Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther. 2000; 292:156-63.