Quantitative evaluation of MRI and histological characteristics of the 5xFAD Alzheimer mouse brain

NeuroImage

Volumn 76, Issue , 2013, Pages 108-115

  Spencer, N G ^a   Bridges, L R ^b   Elderfield, K ^b   Amir, K ^a   Austen, B ^a   Howe, F A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Amyloid; Alzheimer's disease; Quantitative MRI; Transgenic mouse model

Indexed keywords

AMYLOID BETA PROTEIN; MYELIN BASIC PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELAXATION TIME; TRANSGENIC MOUSE; WHITE MATTER; WILD TYPE;

ALZHEIMER DISEASE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC;

EID: 84876314017     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2013.02.071     Document Type: Article

References (36)

1. Benveniste H., Einstein G., Kim K.R., Hulette C., Johnson G.A. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:14079-14084.
2. Besson J.A.O., Crawford J.R., Parker D.M., Ebmeier K.P., Gemmell H.G., Sharp P.F., Best P.V., Smith F.W. Neuroimaging, cognitive, and pathological-changes in dementia of the Alzheimer type (Dat). Psychiatry Res. 1989, 29:447-448.
3. Boretius S., Kasper L., Tammer R., Michaelis T., Frahm J. MRI of cellular layers in mouse brain in vivo. Neuroimage 2009, 47:1252-1260.
4. Borthakur A., Gur T., Wheaton A.J., Corbo M., Trojanowski J.Q., Lee V.M., Reddy R. In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. J. Magn. Reson. Imaging 2006, 24:1011-1017.
5. Braakman N., Matysik J., van Duinen S.G., Verbeek F., Schliebs R., de Groot H.J., Alia A. Longitudinal assessment of Alzheimer's beta-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging. J. Magn. Reson. Imaging 2006, 24:530-536.
6. Choi S.R., Golding G., Zhuang Z., Zhang W., Lim N., Hefti F., Benedum T.E., Kilbourn M.R., Skovronsky D., Kung H.F. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J. Nucl. Med. 2009, 50:1887-1894.
7. Clinton J., Roberts G.W., Gentleman S.M., Royston M.C. Differential pattern of beta-amyloid protein deposition within cortical sulci and gyri in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 1993, 19:277-281.
8. Eickhoff S., Walters N.B., Schleicher A., Kril J., Egan G.F., Zilles K., Watson J.D.G., Amunts K. High-resolution MRI reflects myeloarchitecture and cytoarchitecture of human cerebral cortex. Hum. Brain Mapp. 2005, 24:206-215.
9. El Tannir El Tayara N., Delatour B., Le Cudennec C., Guégan M., Volk A., Dhenain M. Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 2006, 22:199-208.
10. Falangola M.F., Lee S.P., Nixon R.A., Duff K., Helpern J.A. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem. Res. 2005, 30:201-205.
11. Falangola M.F., Ardekani B. a, Lee S.P., Babb J.S., Bogart a., Dyakin V.V., Nixon R., Duff K., Helpern J. a Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. J. Neurosci. Methods 2005, 144:91-97.
12. Gouw A.A., Seewann A., Vrenken H., van der Flier W.M., Rozemuller J.M., Barkhof F., Scheltens P., Geurts J.J.G. Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology. Brain 2008, 131:3286-3298.
13. Haris M., Singh A., Cai K.J., McArdle E., Fenty M., Davatzikos C., Trojanowski J.Q., Melhem E.R., Clark C.M., Borthakur A. T-1 rho MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe. J. Neuroimaging 2011, 21:e86-e90.
14. Helpern J. a, Lee S.-P., Falangola M.F., Dyakin V.V., Bogart A., Ardekani B., Duff K., Branch C., Wisniewski T., de Leon M.J., Wolf O., O'Shea J., Nixon R. a MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn. Reson. Med. 2004, 51:794-798.
15. Higuchi M., Iwata N., Matsuba Y., Sato K., Sasamoto K., Saido T.C. 19F and 1H MRI detection of amyloid beta plaques in vivo. Nat. Neurosci. 2005, 8:527-533.
16. Jack C.R., Garwood M., Wengenack T.M., Borowski B., Curran G.L., Lin J., Adriany G., Gröhn O.H.J., Grimm R., Poduslo J.F. In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn. Reson. Med. 2004, 52:1263-1271.
17. Jack C.R., Wengenack T.M., Reyes D. a, Garwood M., Curran G.L., Borowski B.J., Lin J., Preboske G.M., Holasek S.S., Adriany G., Poduslo J.F. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J. Neurosci. 2005, 25:10041-10048.
18. Klunk W.E., Lopresti B.J., Ikonomovic M.D., Lefterov I.M., Koldamova R.P., Abrahamson E.E., Debnath M.L., Holt D.P., Huang G.F., Shao L., DeKosky S.T., Price J.C., Mathis C.A. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain. J. Neurosci. 2005, 25:10598-10606.
19. Lee S.-P., Falangola M.F., Nixon R. a., Duff K., Helpern J. a. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn. Reson. Med. 2004, 52:538-544.
20. Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 2006, 26:10129-10140.
21. Petiet A., Santin M., Bertrand A., Wiggins C.J., Petit F., Houitte D., Hantraye P., Benavides J., Debeir T., Rooney T., Dhenain M. Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice. Neurobiol. Aging 2012, 33:1533-1544.
22. Poduslo J.F., Wengenack T.M., Curran G.L., Wisniewski T., Sigurdsson E.M., Macura S.I., Borowski B.J., Jack C.R. Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging. Neurobiol. Dis. 2002, 11:315-329.
23. Ridha B.H., Tozer D.J., Symms M.R., Stockton K.C., Lewis E.B., Siddique M.M., MacManus D.G., Rossor M.N., Fox N.C., Tofts P.S. Quantitative magnetization transfer imaging in Alzheimer disease. Radiology 2007, 244:832-837.
24. Rugg-Gunn F.J., Boulby P.A., Symms M.R., Barker G.J., Duncan J.S. Whole-brain T2 mapping demonstrates occult abnormalities in focal epilepsy. Neurology 2005, 64:318-325.
25. Schmierer K., Parkes H.G., So P.-W., An S.F., Brandner S., Ordidge R.J., Yousry T. a, Miller D.H. High field (9.4Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis. Brain 2010, 133:858-867.
26. Schmitz C., Rutten B.P., Pielen A., Schafer S., Wirths O., Tremp G., Czech C., Blanchard V., Multhaup G., Rezaie P., Korr H., Steinbusch H.W., Pradier L., Bayer T.A. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 2004, 164:1495-1502.
27. Selkoe D.J. Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease. Handb. Clin. Neurol. 2008, 89:245-260.
28. Sereno M.I., Lutti A., Weiskopf N., Dick F. Mapping the human cortical surface by combining quantitative T1 with retinotopy. Cereb. Cortex 2012.
29. Sigurdsson E.M., Wadghiri Y.Z., Mosconi L., Blind J.A., Knudsen E., Asuni A., Scholtzova H., Tsui W.H., Li Y., Sadowski M., Turnbull D.H., de Leon M.J., Wisniewski T. A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiol. Aging 2008, 29:836-847.
30. Teipel S.J., Kaza E., Hadlich S., Bauer A., Bruning T., Plath A.S., Krohn M., Scheffler K., Walker L.C., Lotze M., Pahnke J. Automated detection of amyloid-beta-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI. J. Alzheimers Dis. 2011, 23:221-237.
31. Thevenaz P., Ruttimann U.E., Unser M. A pyramid approach to subpixel registration based on intensity. IEEE Trans. Image Process. 1998, 7:27-41.
32. Vanhoutte G., Dewachter I., Borghgraef P., Van Leuven F., Van der Linden a. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magn. Reson. Med. 2005, 53:607-613.
33. Wadghiri Y.Z., Sigurdsson E.M., Sadowski M., Elliott J.I., Li Y., Scholtzova H., Tang C.Y., Aguinaldo G., Pappolla M., Duff K., Wisniewski T., Turnbull D.H. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn. Reson. Med. 2003, 50:293-302.
34. Walters N.B., Egan G.F., Kril J.J., Kean M., Waley P., Jenkinson M., Watson J.D.G. In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:2981-2986.
35. Zhang J., Yarowsky P., Gordon M.N., Di Carlo G., Munireddy S., van Zijl P.C.M., Mori S. Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging. Magn. Reson. Med. 2004, 51:452-457.
36. Zilles K. Architecture of the human cortex - regional and laminar organization. The Human Nervous System 2004, Elsevier Academic Press, Amsterdam, Boston. 2nd ed. G. Paxinos, J.K. Mai (Eds.).