-
1
-
-
79959795786
-
BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al., BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364:2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
2
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in nonsmall-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in nonsmall-cell lung cancer. N Engl J Med 2010; 363:1693-1703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
3
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim ES, Herbst RS, Wistuba II, et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 2011; 1:44-53.
-
(2011)
Cancer Discov
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
-
4
-
-
84869223443
-
Personalized medicine in a phase i clinical trials program: The MD Anderson Cancer Center initiative
-
Tsimberidou AM, Iskander NG, Hong DS, et al. Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res 2012; 18:6373-6383.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6373-6383
-
-
Tsimberidou, A.M.1
Iskander, N.G.2
Hong, D.S.3
-
5
-
-
0018763702
-
The variability of estrogen receptors in metastatic breast cancer
-
Brennan MJ, Donegan WL, Appleby DE. The variability of estrogen receptors in metastatic breast cancer. Am J Surg 1979; 137:260-262.
-
(1979)
Am J Surg
, vol.137
, pp. 260-262
-
-
Brennan, M.J.1
Donegan, W.L.2
Appleby, D.E.3
-
6
-
-
0020596899
-
Variation in receptor status between primary and metastatic breast cancer
-
Holdaway IM, Bowditch JV. Variation in receptor status between primary and metastatic breast cancer. Cancer 1983; 52:479-485.
-
(1983)
Cancer
, vol.52
, pp. 479-485
-
-
Holdaway, I.M.1
Bowditch, J.V.2
-
7
-
-
84857568955
-
Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer
-
Amir E, Miller N, Geddie W, et al. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol 2012; 30:587-592.
-
(2012)
J Clin Oncol
, vol.30
, pp. 587-592
-
-
Amir, E.1
Miller, N.2
Geddie, W.3
-
8
-
-
84863116159
-
Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
-
Niikura N, Liu J, Hayashi N, et al. Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol 2012; 30:593-599.
-
(2012)
J Clin Oncol
, vol.30
, pp. 593-599
-
-
Niikura, N.1
Liu, J.2
Hayashi, N.3
-
9
-
-
84861699124
-
Tissue confirmation of disease recurrence in breast cancer patients: Pooled analysis of multicentre, multi-disciplinary prospective studies
-
Amir E, Clemons M, Purdie CA, et al. Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multicentre, multi-disciplinary prospective studies. Cancer Treat Rev 2012; 38:708-714.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 708-714
-
-
Amir, E.1
Clemons, M.2
Purdie, C.A.3
-
10
-
-
77956406352
-
Ethics of mandatory research biopsy for correlative end points within clinical trials in oncology
-
Peppercorn J, Shapira I, Collyar D, et al. Ethics of mandatory research biopsy for correlative end points within clinical trials in oncology. J Clin Oncol 2010; 28:2635-2640.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2635-2640
-
-
Peppercorn, J.1
Shapira, I.2
Collyar, D.3
-
11
-
-
80053196189
-
Outcomes of research biopsies in phase i clinical trials: The MD anderson cancer center experience
-
El-Osta H, Hong D, Wheler J, et al. Outcomes of research biopsies in phase I clinical trials: the MD anderson cancer center experience. Oncologist 2011; 16:1292-1298.
-
(2011)
Oncologist
, vol.16
, pp. 1292-1298
-
-
El-Osta, H.1
Hong, D.2
Wheler, J.3
-
12
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366:883-892.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
13
-
-
84865186133
-
Comparative genomic analysis of primary versus metastatic colorectal carcinomas
-
Vakiani E, Janakiraman M, Shen R, et al. Comparative genomic analysis of primary versus metastatic colorectal carcinomas. J Clin Oncol 2012; 30:2956-2962.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2956-2962
-
-
Vakiani, E.1
Janakiraman, M.2
Shen, R.3
-
14
-
-
84865167805
-
Concordance and discordance in tumor genomic profiling
-
Garraway LA. Concordance and discordance in tumor genomic profiling. J Clin Oncol 2012; 30:2937-2939.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2937-2939
-
-
Garraway, L.A.1
-
15
-
-
84866334608
-
Whole-genome sequencing and cancer therapy: Is too much ever enough?
-
Garraway LA, Baselga J. Whole-genome sequencing and cancer therapy: is too much ever enough? Cancer Discov 2012; 2:766-768.
-
(2012)
Cancer Discov
, vol.2
, pp. 766-768
-
-
Garraway, L.A.1
Baselga, J.2
-
16
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
17
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Cancer Genome Project.
-
Cancer Genome Project. The landscape of cancer genes and mutational processes in breast cancer. Nature 2012; 486:400-404.
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
-
18
-
-
84868320535
-
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endo-metrial cancer
-
Liang H, Cheung LW, Li J, et al. Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endo-metrial cancer. Genome Res 2012; 22:2120-2129.
-
(2012)
Genome Res
, vol.22
, pp. 2120-2129
-
-
Liang, H.1
Cheung, L.W.2
Li, J.3
-
19
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474:609-615.
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
20
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network; Hammerman PS, Hayes DN, Wilkerson MD, et al. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012; 489:519-525.
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
Hammerman, P.S.1
Hayes, D.N.2
Wilkerson, M.D.3
-
21
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
Imielinski M, Berger AH, Hammerman PS, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012; 150:1107-1120.
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
Berger, A.H.2
Hammerman, P.S.3
-
22
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-337.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
23
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483:100-103.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
24
-
-
84870878845
-
Cost-effectiveness analysis of screening for KRAS and BRAF mutations in metastatic colorectal cancer
-
Behl AS, Goddard KA, Flottemesch TJ, et al. Cost-effectiveness analysis of screening for KRAS and BRAF mutations in metastatic colorectal cancer. J Natl Cancer Inst 2012; 104:1785-1795.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 1785-1795
-
-
Behl, A.S.1
Goddard, K.A.2
Flottemesch, T.J.3
-
25
-
-
84863012433
-
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer
-
Yang H, Higgins B, Kolinsky K, et al. Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. Cancer Res 2012; 72:779-789.
-
(2012)
Cancer Res
, vol.72
, pp. 779-789
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
-
26
-
-
0037186915
-
International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al., International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346:645-652.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
27
-
-
84869236330
-
Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors
-
Yachida S, White CM, Naito Y, et al. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clin Cancer Res 2012; 18:6339-6347.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6339-6347
-
-
Yachida, S.1
White, C.M.2
Naito, Y.3
-
28
-
-
84859463451
-
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
-
Maurer T, Garrenton LS, Oh A, et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci USA 2012; 109:5299-5304.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 5299-5304
-
-
Maurer, T.1
Garrenton, L.S.2
Oh, A.3
-
29
-
-
84874888512
-
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer
-
Kim HR, Kim DJ, Kang DR, et al. Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J Clin Oncol 2013; 31:731-737.
-
(2013)
J Clin Oncol
, vol.31
, pp. 731-737
-
-
Kim, H.R.1
Kim, D.J.2
Kang, D.R.3
-
30
-
-
84873918443
-
Activating HER2 mutations in HER2 gene amplification negative breast cancer
-
Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 2013; 3:1-14.
-
(2013)
Cancer Discov
, vol.3
, pp. 1-14
-
-
Bose, R.1
Kavuri, S.M.2
Searleman, A.C.3
-
31
-
-
79551521053
-
Phase III trial assessing bevaci-zumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
-
Allegra CJ, Yothers G, O'Connell MJ, et al. Phase III trial assessing bevaci-zumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol 2011; 29:11-16.
-
(2011)
J Clin Oncol
, vol.29
, pp. 11-16
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
-
32
-
-
84859403854
-
Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: A randomized trial
-
Alberts SR, Sargent DJ, Nair S, et al. Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: a randomized trial. JAMA 2012; 307:1383-1393.
-
(2012)
JAMA
, vol.307
, pp. 1383-1393
-
-
Alberts, S.R.1
Sargent, D.J.2
Nair, S.3
-
33
-
-
79953874259
-
RIBBON-1: Randomized double-blind placebo-controlled phase III trial of chemotherapy with or without bevacizu-mab for first-line treatment of human epidermal growth factor receptor 2-negative locally recurrent or metastatic breast cancer
-
Robert NJ, Diéras V, Glaspy J, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizu-mab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011; 29:1252-1260.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1252-1260
-
-
Robert, N.J.1
Diéras, V.2
Glaspy, J.3
-
34
-
-
81155123190
-
RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bev-acizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Brufsky AM, Hurvitz S, Perez E, et al. RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bev-acizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2011; 29:4286-4293.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4286-4293
-
-
Brufsky, A.M.1
Hurvitz, S.2
Perez, E.3
-
35
-
-
84876285095
-
Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer
-
Cameron D, Brown J, Dent R, et al. Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer. Cancer Res 2012; 72(24 Suppl):Abstract S6-5.
-
(2012)
Cancer Res
, vol.72
, Issue.24 SUPPL.
-
-
Cameron, D.1
Brown, J.2
Dent, R.3
-
36
-
-
84861690508
-
Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401
-
Kelly WK, Halabi S, Carducci M, et al. Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401. J Clin Oncol 2012; 30:1534-1540.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1534-1540
-
-
Kelly, W.K.1
Halabi, S.2
Carducci, M.3
-
37
-
-
84865165918
-
The price we pay for progress: A meta-analysis of harms of newly approved anticancer drugs
-
Niraula S, Seruga B, Ocana A, et al. The price we pay for progress: a meta-analysis of harms of newly approved anticancer drugs. J Clin Oncol 2012; 30:3012-3019.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3012-3019
-
-
Niraula, S.1
Seruga, B.2
Ocana, A.3
-
38
-
-
79952083872
-
Congestive heart failure risk in patients with breast cancer treated with bevacizumab
-
Choueiri TK, Mayer EL, Je Y, et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 2011; 29:632-638.
-
(2011)
J Clin Oncol
, vol.29
, pp. 632-638
-
-
Choueiri, T.K.1
Mayer, E.L.2
Je, Y.3
-
39
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366:520-529.
-
(2012)
N Engl J Med
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
40
-
-
84867333656
-
Genome sequencing identifiesabasis for everolimus sensitivity
-
Iyer G, Hanrahan AJ, Milowsky MI, et al. Genome sequencing identifiesabasis for everolimus sensitivity. Science 2012; 338:221.
-
(2012)
Science
, vol.338
, pp. 221
-
-
Iyer, G.1
Hanrahan, A.J.2
Milowsky, M.I.3
-
41
-
-
84863673204
-
METRIC Study Group. Improved survival with MEK inhibition in BRAF-mutated melanoma
-
Flaherty KT, Robert C, Hersey P, et al., METRIC Study Group. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012; 367:107-114.
-
(2012)
N Engl J Med
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
42
-
-
84866342282
-
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors
-
Dahlman KB, Xia J, Hutchinson K, et al. BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. Cancer Discov 2012; 2:791-797.
-
(2012)
Cancer Discov
, vol.2
, pp. 791-797
-
-
Dahlman, K.B.1
Xia, J.2
Hutchinson, K.3
-
43
-
-
39849106879
-
FDG PET and risk-adapted therapy in Hodgkin's and non-Hodgkin's lymphoma
-
Kasamon YL, Wahl RL. FDG PET and risk-adapted therapy in Hodgkin's and non-Hodgkin's lymphoma. Curr Opin Oncol 2008; 20:206-219.
-
(2008)
Curr Opin Oncol
, vol.20
, pp. 206-219
-
-
Kasamon, Y.L.1
Wahl, R.L.2
-
44
-
-
84859118421
-
Personalized tumor response assessment in the era of molecular medicine: Cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST
-
Nishino M, Jagannathan JP, Krajewski KM, et al. Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST. AJR Am J Roentgenol 2012; 198:737-745.
-
(2012)
AJR Am J Roentgenol
, vol.198
, pp. 737-745
-
-
Nishino, M.1
Jagannathan, J.P.2
Krajewski, K.M.3
-
45
-
-
66149139452
-
From RECIST to PERCIST: Evolving considerations for PET response criteria in solid tumors
-
Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 2009; 50 (Suppl. 1):122S-150S.
-
(2009)
J Nucl Med
, vol.50
, Issue.SUPPL. 1
-
-
Wahl, R.L.1
Jacene, H.2
Kasamon, Y.3
Lodge, M.A.4
-
46
-
-
84870442338
-
Differences in the biologic activity of 2 novel MEK inhibitors revealed by 18F-FDG PET: Analysis of imaging data from 2 phase i trials
-
Kraeber-Bodéré F, Carlier T, Naegelen VM, et al. Differences in the biologic activity of 2 novel MEK inhibitors revealed by 18F-FDG PET: analysis of imaging data from 2 phase I trials. J Nucl Med 2012; 53: 1836-1846.
-
(2012)
J Nucl Med
, vol.53
, pp. 1836-1846
-
-
Kraeber-Bodéré, F.1
Carlier, T.2
Naegelen, V.M.3
-
47
-
-
84869213195
-
89Zr-bevacizumab PET as an early biomarker for the antiangiogenic effect of everolimus treatment in an ovarian cancer xenograft model
-
89Zr-bevacizumab PET as an early biomarker for the antiangiogenic effect of everolimus treatment in an ovarian cancer xenograft model. Clin Cancer Res 2012; 18:6306-6314.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6306-6314
-
-
Van Der Bilt, A.R.1
Terwisscha Van Scheltinga, A.G.2
Timmer-Bosscha, H.3
-
49
-
-
84869435971
-
Six cycles of doxorubicin and cyclophosphamide or paclitaxel are not superior to four cycles as adjuvant chemotherapy for breast cancer in women with zero to three positive axillary nodes: Cancer and leukemia group B 40101
-
Shulman LN, Cirrincione CT, Berry DA, et al. Six cycles of doxorubicin and cyclophosphamide or paclitaxel are not superior to four cycles as adjuvant chemotherapy for breast cancer in women with zero to three positive axillary nodes: cancer and leukemia group B 40101. J Clin Oncol 2012; 30:4071-4076.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4071-4076
-
-
Shulman, L.N.1
Cirrincione, C.T.2
Berry, D.A.3
-
50
-
-
84862914692
-
CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortés J, Kim SB, et al., CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012; 366:109-119.
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortés, J.2
Kim, S.B.3
-
51
-
-
84855297353
-
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
-
Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012; 13:25-32.
-
(2012)
Lancet Oncol
, vol.13
, pp. 25-32
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
-
52
-
-
84868520609
-
EMILIA Study Group. Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L, et al., EMILIA Study Group. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012; 367:1783-1791.
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
53
-
-
84866681744
-
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
-
Ibrahim YH, Garćia-Garćia C, Serra V, et al. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2012; 2:1036-1047.
-
(2012)
Cancer Discov
, vol.2
, pp. 1036-1047
-
-
Ibrahim, Y.H.1
Garćia-Garćia, C.2
Serra, V.3
-
54
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
doi: 10.1016/S0140-6736(12) 60868-X.
-
Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012; 380:358-365. doi: 10.1016/S0140-6736(12) 60868-X.
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
55
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367:1694-1703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
56
-
-
78049426513
-
ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi YL, Soda M, Yamashita Y, et al., ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 2010; 363:1734-1739.
-
(2010)
N Engl J Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
57
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman R, Morikawa T, Shee K, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012; 487:500-504.
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
-
58
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011; 3:75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
59
-
-
84872858690
-
Genotype-selective combination therapies for melanoma identified by high-throughput drug screening
-
Held MA, Langdon CG, Platt JT, et al. Genotype-selective combination therapies for melanoma identified by high-throughput drug screening. Cancer Discov 2013; 3:52-67.
-
(2013)
Cancer Discov
, vol.3
, pp. 52-67
-
-
Held, M.A.1
Langdon, C.G.2
Platt, J.T.3
-
60
-
-
84873084388
-
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
-
Kreso A, O'Brien CA, van Galen P, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2013; 339:543-548.
-
(2013)
Science
, vol.339
, pp. 543-548
-
-
Kreso, A.1
O'Brien, C.A.2
Van Galen, P.3
-
61
-
-
84855218212
-
LANDSCAPE: An FNCLCC phaseII study with lapatinib (L) and capecitabine (C) in patients with brain metastases (BM) from HER2-positive (+) metastatic breast cancer (MBC) before whole-brain radiotherapy (WBR)
-
Bachelot TD, Romieu G, Campone M, et al. LANDSCAPE: An FNCLCC phaseII study with lapatinib (L) and capecitabine (C) in patients with brain metastases (BM) from HER2-positive (+) metastatic breast cancer (MBC) before whole-brain radiotherapy (WBR). J Clin Oncol 2011; 29(Suppl.; abstr 509).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
, pp. 509
-
-
Bachelot, T.D.1
Romieu, G.2
Campone, M.3
-
62
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
-
Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet 2012; 379:1893-1901.
-
(2012)
Lancet
, vol.379
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
Kurzrock, R.3
-
63
-
-
84870714044
-
Special series on comparative effectiveness research: Chal lenges to real-world solutions to quality improvement in personalized medicine
-
Browman GP. Special series on comparative effectiveness research: chal lenges to real-world solutions to quality improvement in personalized medicine. J Clin Oncol 2012; 30:4188-4191.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4188-4191
-
-
Browman, G.P.1
|