Resistin expression correlates with steatohepatitis in morbidly obese patients

Surgical Endoscopy

Volumn 27, Issue 4, 2013, Pages 1310-1314

  Edwards, Claire R ^a   Hindle, A Katharine ^a   Latham, Patricia S ^a   Fu, Sidney W ^a   Brody, Fred J ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adipokines; Bariatric surgery; Genomics; Nonalcoholic steatohepatitis; Resistin

Indexed keywords

COMPLEMENTARY DNA; RESISTIN; RNA 18S;

ADULT; AGE DISTRIBUTION; ARTICLE; BARIATRIC SURGERY; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA SYNTHESIS; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HEPATITIS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MALE; MORBID OBESITY; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RESISTIN GENE; RNA EXTRACTION;

EID: 84876296465     PISSN: 09302794     EISSN: 14322218     Source Type: Journal    
DOI: 10.1007/s00464-012-2603-y     Document Type: Article

References (22)

1. Younossi ZM (2008) Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 28:2-12
2. Diehl AM (2010) Hepatic complications of obesity. Gastroenterol Clin N Am 39:57-68
3. Baranova A, Younossi ZM (2008) The future is around the corner: noninvasive diagnosis of progressive nonalcoholic steatohepatitis. Hepatology 47:373-375
4. Younossi ZM, Jarrar M, Nugent C, Randhawa M, Afendy M, Stepanova M, Rafiq N, Goodman Z, Chandhoke V, Baranova A (2008) A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). Obes Surg 18:1430-1437
5. Cheung O, Sanyal AJ (2010) Recent advances in nonalcoholic fatty liver disease. Curr 26:202-208
6. Edwards C, Hindle AK, Fu S, Brody F (2011) Downregulation of leptin and resistin expression in blood following bariatric surgery. Surg Endosc 25:1962-1968
7. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu Y-C, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313-1321
8. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312
9. Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, Forlani G, Melchionda N (1999) Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107:450-455
10. Bertolani C, Sancho-Bru P, Failli P, Bataller R, Aleffi S, DeFranco R, Mazzinghi B, Romagnani P, Milani S, Gines P, Colmenero J, Parola M, Gelmini S, Tarquini R, Laffi G, Pinzani M, Marra F (2006) Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol 169:2042-2053
11. Pagano C, Soardo G, Pilon C, Milocco C, Basan L, Milan G, Donnini D, Faggian D, Mussap M, Plebani M, Avellini C, Federspil G, Sechi LA, Vettor R (2006) Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. J Clin Endocrinol Metab 91:1081-1086
12. Singhal NS, Patel RT, Qi Y, Lee Y-S, Ahima RS (2008) Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab 295:E331-E338
13. Tarkowski A, Bjersing J, Shestakov A, Bokarewa MI (2010) Resistin competes with lipopolysaccharide for binding to toll-like receptor 4. J Cell Mol Med 14:1419-1431
14. Pradere J-P, Troeger JS, Dapito DH, Mencin AA, Schwabe RF (2010) Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis 30:232-244
15. Testro AG, Visvanathan K (2009) Toll-like receptors and their role in gastrointestinal disease. J Gastroenterol Hepatol 24:943-954
16. Jiang L-L, Li L, Hong X-F, Li Y-M, Zhang B-L (2009) Patients with nonalcoholic fatty liver disease display increased serum resistin levels and decreased adiponectin levels. Eur J Gastroenterol Hepatol 21:662-666
17. Bajaj M, Suraamornkul S, Hardies LJ, Pratipanawatr T, DeFronzo RA (2004) Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients. Int J Obes Relat Metab Disord 28:783-789
18. Perseghin G, Lattuada G, De Cobelli F, Ntali G, Esposito A, Burska A, Belloni E, Canu T, Ragogna F, Scifo P, Del Maschio A, Luzi L (2006) Serum resistin and hepatic fat content in nondiabetic individuals. J Clin Endocrinol Metab 91:5122-5125
19. McTernan PG, Kusminski CM, Kumar S (2006) Resistin. Curr Opin Lipidol 17:170-175
20. Mattar SG, Velcu LM, Rabinovitz M, Barinas-Mitchell E, Eid GM, Ramanathan R, Taylor DS, Schauer PR (2005) Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg 242:610-617 discussion 618-620
21. Moschen AR, Molnar C, Wolf AM, Weiss H, Graziadei I, Kaser S, Ebenbichler CF, Stadlmann S, Moser PL, Tilg H (2009) Effects of weight loss induced by bariatric surgery on hepatic adipocytokine expression. J Hepatol 51:765-777
22. Kral JG, Thung SN, Biron S, Hould F-S, Lebel S, Marceau S, Simard S, Marceau P (2004) Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery 135:48-58