Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Journal of the International Society of Sports Nutrition

Volumn 10, Issue , 2013, Pages

  Lopez, Hector L ^a   Ziegenfuss, Tim N ^a   Hofheins, Jennifer E ^a   Habowski, Scott M ^a   Arent, Shawn M ^b   Weir, Joseph P ^c   Ferrando, Arny A ^d  

^a Center for Applied Health Sciences   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Adipokine; Body composition; Capsaicin; Dietary supplement; Fat loss; Raspberry ketone

Indexed keywords

ALLIUM SATIVUM; CITRUS AURANTIUM; RUBUS GLAUCUS; ZINGIBER OFFICINALE;

EID: 84876292897     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-10-22     Document Type: Article

References (51)

1. Dixon JB. The effect of obesity on health outcomes. Mol Cell Endocrinol 2009, 316:104-108.
2. Adult Obesity Facts, Centers for Disease Control and Prevention http://www.cdc.gov/obesity/data/adult.html.
3. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W. Annual medical spending attributable to obesity; payer-and service-specific estimates. Health Aff 2009, 28:w822-w831.
4. Metabolic Syndrome, MedinePlus http://www.nlm.nih.gov/medlineplus/metabolicsyndrome.html.
5. Scarpellini E, Tack J. Obesity and metabolic syndrome: an inflammatory condition. Dig Dis 2012, 30:148-153. 10.1159/000336664, 22722429.
6. Smith MM, Minson CT. Obesity and adipokines: effects on sympathetic overactivity. J Physiol 2012, 590(Pt 8):1787-1801. 3573303, 22351630.
7. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999, 257:79-83. 10.1006/bbrc.1999.0255, 10092513.
8. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000, 20:1595-1619. 10.1161/01.ATV.20.6.1595, 10845877.
9. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y, Osaka CAD, . Study Group Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003, 23:85-89. 10.1161/01.ATV.0000048856.22331.50, 12524229, Study Group.
10. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003, 42:231-234. 10.1161/01.HYP.0000083488.67550.B8, 12860835.
11. Trujillo ME, Scherer PE. Adiponectin: Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005, 257:167-175. 10.1111/j.1365-2796.2004.01426.x, 15656875.
12. Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life Sci 2005, 77:194-204. 10.1016/j.lfs.2004.12.029, 15862604.
13. Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3 T3-L1 adipocytes. Planta Med 2010, 76:1654-1658. 10.1055/s-0030-1249860, 20425690.
14. Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 2007, 292:R77-R85.
15. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab 2010, 7:65.
16. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012, 95:845-850. 10.3945/ajcn.111.018606, 22378725.
17. Bloomer R, Canale R, Shastri S, Suvarnapathki S. Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double-blind, cross-over study. Lipids Health Dis 2010, 9:72. 10.1186/1476-511X-9-72, 2912905, 20633266.
18. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I. Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem 2011, 54:6295-6304. 10.1021/jm200662c, 21851089.
19. Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T. 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3 T3-L1 adipocytes. Biochem Biophys Res Commun 2008, 373:429-434. 10.1016/j.bbrc.2008.06.046, 18577375.
20. Ban JO, Lee DH, Kim EJ, Kang JW, Kim MS, Cho MC, Jeong HS, Kim JW, Yang Y, Hong JT, Yoon do Y. Antiobesity effects of a sulfur compound thiacremonone mediated via down-regulation of serum triglyceride and glucose levels and lipid accumulation in the liver of db/db mice. Phytother Res 2012, 26:1265-1271. 10.1002/ptr.3729, 22228551.
21. Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ. Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome. Am J Hypertens 2007, 20:866-874. 10.1016/j.amjhyper.2007.02.015, 2930912, 17679035.
22. Stohs SJ, Preuss HG, Shara M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci 2012, 9:527-538. 10.7150/ijms.4446, 3444973, 22991491.
23. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990, 51:241-247.
24. Martin CK, O'Neil PM, Tollesfson G, Greenway FL, Marney AW. The association between food cravings and consumption of specific foods in a laboratory taste test. Appetite 2008, 51:324-326. 10.1016/j.appet.2008.03.002, 2748323, 18417253.
25. Weir JP. Quantifying test-retest reliability using the intraclass correlation coefficient. J Strength Cond Res 2005, 19:231-240.
26. Lohman T, Martorell R, Roche AF. Anthropometric standardization reference manual 1988, Champaign, IL: Human Kinetics Books.
27. Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC. AIDS Clinical Trials Group (ACTG) 5157 protocol team. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. HIV Med 2009, 10:103-110. 10.1111/j.1468-1293.2008.00658.x, 2653263, 19200173.
28. Campbell WW, Haub MD, Wolfe RR, Ferrando AA, Sullivan DH, Apolzan JW, Iglay HB. Resistance training preserves fat-free mass without impacting changes in protein metabolism after weight loss in older women. Obesity (Silver Spring) 2009, 17:1332-1339.
29. Hunter GB, Bryne NM, Sirikul B, Fernandez JR, Zuckermann PA, Darnell BE, Gower BA. Resistance training conserves fat-free mass and resting energy expenditure following weight loss. Obesity (Silver Spring) 2008, 16:1045-1051.
30. Weinheimer EM, Sands LP, Campbell WW. A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass on middle-aged and older adults: implications for sarcopenic obesity. Nutt Rev 2010, 68:375-388.
31. Hunter GR, Brock DW, Byrne NM, Chandler-Laney PC, Del Corral P, Gower BA. Exercise training prevents regain of visceral fat for 1 year following weight loss. Obesity (Silver Spring) 2010, 18:690-695.
32. Strychar I, Lavoie ME, Messier K, Krelis AD, Doucet E, Prud'homme D, Fontaine J, Rabasa-Lhoret R. Anthropometric, metabolic, psychosocial, and dietary characteristics of overweight/obese postmenopausal women with a history of weight cycling: a MONET (Montreal Ottawa New Emerging Team) study. J Am Diet Assoc 2009, 109:718-724. 10.1016/j.jada.2008.12.026, 19328269.
33. Sadashiv Tiwari S, Paul BN, Kumar S, Chandra A, Dhananiai S, Negi MP. Over expression of resistin in adipose tissue of the obese induces insulin resistin. World J Diabetes 2012, 3:135-141. 10.4239/wjd.v3.i7.135, 3399912, 22816026.
34. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011, 11:85-97. 10.1038/nri2921, 3518031, 21252989.
35. Baicy K, London ED, Monterosso J, Wong ML, Delibasi T, Sharma A, Licinio J. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci 2007, 104:18276-18279. 10.1073/pnas.0706481104, 2084333, 17986612.
36. Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against non-alcoholic steatohepatitis. J Med Food 2012, 15:495-503. 10.1089/jmf.2011.1717, 22551412.
37. Ludy MJ, Moore GE, Mattes RD. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012, 37:103-121. 10.1093/chemse/bjr100, 3257466, 22038945.
38. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009, 89:45-50. 3151435, 19056576.
39. Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012, 59:341-348. 10.1016/j.appet.2012.05.015, 22634197.
40. Carpéné C, Galitzky J, Fontana E, Atgié C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol 1999, 359:310-321. 10.1007/PL00005357, 10344530.
41. Sae-tan S, Grove KA, Lambert JD. Weight control and prevention of metabolic syndrome by green tea. Parmacol Res 2011, 64:146-154.
42. Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr 2009, 63:57-64. 10.1038/sj.ejcn.1602901, 17882140.
43. Maridakis V, Herring MP, O'Connor PJ. Sensitivity to change in cognitive performance and mood measures of energy and fatigue in response to differing doses of caffeine or breakfast. Int J Neurosci 2009, 119:975-994. 10.1080/00207450802333995, 19466633.
44. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, Taylor L, Willoughby D, Stout J, Graves BS, Wildman R, Ivy JL, Spano M, Smith AE, Antonio J. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 2010, 7:5. 10.1186/1550-2783-7-5, 2824625, 20205813.
45. Hursel R, Westerterp-Plantenga MS. Thermogenic ingredients and body weight regulation. Int J Obes (Lond) 2010, 34:659-669.
46. Ahnis A, Riedl A, Figura A, Steinhagen-Thiessen E, Liebl ME, Klapp BF. Psychological and sociodemographic predictors of premature discontinuation of a 1-year multimodal outpatient weight-reduction program: an attrition analysis. Patient Prefer Adherence 2012, 6:165-177. 3307662, 22442628.
47. Inelmen EM, Toffanello ED, Enzi G, Gasparini G, Miotto F, Sergi G, Busetto L. Predictors of drop-out in overweight and obese outpatients. Int J Obes (Lond) 2005, 29(1):122-128.
48. Black AE, Prentice AM, Goldberg GR, Jebb SA, Bingham SA, Livingstone MB, Coward WA. Measurements of total energy expenditure provide insights into the validity of dietary measurements of energy intake. J Am Diet Assoc 1993, 93:572-579. 10.1016/0002-8223(93)91820-G, 8315169.
49. Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D. 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr 2009, 139(11):2055-2060. 10.3945/jn.109.105452, 19759245.
50. Sahebkar A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World J Gastroenterol 2011, 14(2):271-272.
51. Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008, 24(1):41-51. 10.1002/dmrr.755, 17506119.