Prediction of recanalization trumps prediction of tissue fate: The penumbra: A dual-edged sword

Stroke

Volumn 44, Issue 4, 2013, Pages 1014-1019

  Zhu, Guangming ^a,c   Michel, Patrik ^d   Aghaebrahim, Amin ^e   Patrie, James T ^b   Xin, Wenjun ^b   Eskandari, Ashraf ^d   Zhang, Weiwei ^c   Wintermark, Max ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Infarct core; Outcome; Penumbra; Recanalization; Stroke

Indexed keywords

ADULT; AGED; ALBERTA SCORE PROGRAM EARLY CT SCORE; ARTICLE; BRAIN ISCHEMIA; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE REGISTRY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PREDICTION; PRIORITY JOURNAL; RANKIN SCALE; RECANALIZATION; SCORING SYSTEM;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; PERFUSION; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; STROKE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84876288464     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000229     Document Type: Article

References (27)

1. Jovin TG, Yonas H, Gebel JM, Kanal E, Chang YF, Grahovac SZ, et al. The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke. 2003;34:2426-2433.
2. Gasparotti R, Grassi M, Mardighian D, Frigerio M, Pavia M, Liserre R, et al. Perfusion CT in patients with acute ischemic stroke treated with intra-Arterial thrombolysis: predictive value of infarct core size on clinical outcome. AJNR Am J Neuroradiol. 2009;30:722-727.
3. Kruetzelmann A, Köhrmann M, Sobesky J, Cheng B, Rosenkranz M, Röther J, et al. Pretreatment diffusion-weighted imaging lesion volume predicts favorable outcome after intravenous thrombolysis with tissue-Type plasminogen activator in acute ischemic stroke. Stroke. 2011;42:1251-1254.
4. Yoo AJ, Chaudhry ZA, Nogueira RG, Lev MH, Schaefer PW, Schwamm LH, et al. Infarct volume is a pivotal biomarker after intra-Arterial stroke therapy. Stroke. 2012;43:1323-1330.
5. Albers G, Straka M, Kemp S, Mlynash M, Jovin T, Wechsler L. Results of DEFUSE 2: imaging endpoints. Stroke: 2012; 43: A52.
6. Mishra NK, Albers GW, Davis SM, Donnan GA, Furlan AJ, Hacke W, et al. Mismatch-based delayed thrombolysis: a meta-Analysis. Stroke. 2010;41:e25-e33.
7. Leiva-Salinas C, Hom J, Warach S, Wintermark M. Stroke imaging research road map. Neuroimaging Clin N Am. 2011;21:239-45, ix.
8. Wintermark M, Flanders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke. 2006;37:979-985.
9. Michel P, Bogousslavsky J. Penumbra is brain: no excuse not to perfuse. Ann Neurol. 2005;58:661-663.
10. González RG. Imaging-guided acute ischemic stroke therapy: From "time is brain" to "physiology is brain". AJNR Am J Neuroradiol. 2006;27:728-735.
11. Donnan GA, Baron JC, Ma H, Davis SM. Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol. 2009;8:261-269.
12. Nakayama H, Jørgensen HS, Raaschou HO, Olsen TS. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke. 1994;25:808-813.
13. Adams HP Jr, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology. 1999;53:126-131.
14. Balucani C, Grotta JC. Selecting stroke patients for intra-Arterial therapy. Neurology. 2012;78:755-761.
15. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al; DEFUSE Investigators. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60:508-517.
16. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al; EPITHET Investigators. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
17. Gupta R, Tayal AH, Levy EI, Cheng-Ching E, Rai A, Liebeskind DS, et al. Intra-Arterial thrombolysis or stent placement during endovascular treatment for acute ischemic stroke leads to the highest recanalization rate: results of a multicenter retrospective study. Neurosurgery. 2011;68:1618-1622; discussion 1622.
18. Syfret DA, Mitchell P, Dowling R, Yan B. Does intra-Arterial thrombolysis have a role as first-line intervention in acute ischaemic stroke? Intern Med J. 2011;41:220-226.
19. Camporese G, Labropoulos N, Verlato F, Bernardi E, Ragazzi R, Salmistraro G, et al; Carotid Recanalization Investigators Group. Benign outcome of objectively proven spontaneous recanalization of internal carotid artery occlusion. J Vasc Surg. 2011;53:323-329.
20. Warach S, Al-Rawi Y, Furlan AJ, Fiebach JB, Wintermark M, Lindstén A, et al. Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials. Stroke. 2012;43:2313-2318.
21. Fiebach JB, Al-Rawi Y, Wintermark M, Furlan AJ, Rowley HA, Lindstén A, et al. Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke. 2012;43:1561-1566.
22. Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, et al; DIAS Study Group. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke. 2005;36:66-73.
23. Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, et al; DEDAS Investigators. Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke. 2006;37:1227-1231.
24. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8:141-150.
25. Kakuda W, Lansberg MG, Thijs VN, Kemp SM, Bammer R, Wechsler LR, et al; DEFUSE Investigators. Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients. J Cereb Blood Flow Metab. 2008;28:887-891.
26. Croquelois A, Wintermark M, Reichhart M, Meuli R, Bogousslavsky J. Aphasia in hyperacute stroke: language follows brain penumbra dynamics. Ann Neurol. 2003;54:321-329.
27. Puig J, Pedraza S, Demchuk A, Daunis-I-Estadella J, Termes H, Blasco G, et al. Quantification of thrombus hounsfield units on noncontrast CT predicts stroke subtype and early recanalization after intravenous recombinant tissue plasminogen activator. AJNR Am J Neuroradiol. 2012;33:90-96.