StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

Journal of Assisted Reproduction and Genetics

Volumn 30, Issue 3, 2013, Pages 437-440

  Jahaninejad, Tahere ^a   Ghasemi, Nasrin ^a   Kalantar, Seyyed Mehdi ^a   Sheikhha, Mohammad Hasan ^a   Pashaiefar, Hossein ^a  

^a SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Androgen receptor; Polymorphism; Recurrent spontaneous abortion; RFLP PCR

Indexed keywords

ANDROGEN RECEPTOR; MEMBRANE PROTEIN; PROTEIN STUI; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BASE PAIRING; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT SPONTANEOUS ABORTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPONTANEOUS ABORTION; WILD TYPE;

EID: 84876284374     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-013-9949-5     Document Type: Article

References (26)

1. Apparao KB, Lovely LP, Gui Y, Lininger RA, Lessey BA. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biol Reprod. 2002;66:297-304.
2. Brosens IA, De Sutter P, Hamerlynck T, Imeraj L, Yao Z, Cloke B, et al. Endometriosis is associated with a decreased risk of preeclampsia. Hum Reprod. 2007;22:1725-9.
3. Brown CJ, Goss SJ, Lubahn DB, Joseph DR, Wilson EM, French FS, et al. Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am J Hum Genet. 1989;44:264-9.
4. Buchholz T, Lohse P, Kosian E, Thaler CJ. Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent spontaneous abortions (RSA). Am J Reprod Immunol. 2004;51(5):323-8.
5. Burger HG. Androgen production in women. Fertil Stril. 2002;77:S3-5.
6. Carrington B, Sacks G, Regan L. Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol. 2005;17(6):591-7.
7. Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. 1994;22:3181-6.
8. Chang C, Saltzman A, Yeh S, Young W, Keller E, Lee HJ, et al. Androgen receptor: an overview. Crit Rev Eukaryot Gene Expr. 1995;5:97-125.
9. Ding D, Xu L, Menon M, Reddy GP, Barrack ER. Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action. Prostate. 2005;62:133-9.
10. Grad JM, Lyons LS, Robins DM, Burnstein KL. The androgen receptor (AR) amino-terminus imposes androgen-specific regulation of AR gene expression via an exonic enhancer. Endocrinology. 2001;142:1107-16.
11. Guay A, Munarriz R, Jacobson J, Talakoub L, Quirk F, Goldstein I, et al. Serum androgen levels healthy premenopausal women with and without sexual dysfunction: part A. Serum androgen levels in women aged 20-49 years with no complaints of sexual dysfunction. Int J Import. 2004;16:112-20.
12. Karvela M, Papadopoulou S, Tsaliki E, Konstantakou E, Hatzaki A, Florentin-Arar L, et al. Endothelial nitric oxide synthase gene polymorphisms in recurrent spontaneous abortions. Arch Gynecol Obstet. 2008;278(4):349-52.
13. Karvela M, Stefanakis N, Papadopoulou S, Tsitilou SG, Tsilivakos V and Lamnissou K. Evidence for association of the G1733A polymorphism of the androgen receptor gene with recurrent spontaneous abortions. Fertil Stril. 2008;90.
14. Li TC, Makris M, Tomsu M, Tuckerman E, Laird S. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update. 2002;8:463-81.
15. Lu J, Danielsen M. A Stu I polymorphism in the human androgen receptor gene (AR). Clin Genet. 1996;49:323-4.
16. Monien S, Kadecki O, Baumgarten S, Salama A, Dörner T, Kiesewetter H. Use of heparin in women with early and late miscarriages with and without thrombophilia. Clin Appl Thromb Hemost. 2009;15(6):636-44.
17. Quigley CA, De Bellis A, Marschke KB, Marschke KB, Marschke KB, el-Awady MK, et al. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev. 1995;16:271-321.
18. Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368(9535):601-11.
19. Redline RW. Thrombophilia and placental pathology. Clin Obstet Gynecol. 2006;49(4):885-94.
20. Regan L. Overview of recurrent miscarriage. Gynaecol Forum. 1998;3:3-7.
21. Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, Takemasa S, et al. Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci USA. 2006;103(1):224-9.
22. Tempfer C, Unfried G, Zeillinger R, Hefler L, Nagele F, Huber JC. Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage. Hum Reprod. 2001;16(8):1644-7.
23. Toth B, Jeschke U, Rogenhofer N, Scholz C, Würfel W, Thaler CJ, et al. Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol. 2010;85(1):25-32.
24. Walters KA, Allan CM, Jimenez M, Lim PR, Davey RA, Zajac JD, et al. Female mice haploin sufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology. 2007;148(8):3674-84.
25. Walter KA, Simanainen U, Handelsman DJ. Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Hum Reprod Update. 2010;16(5):543-58.
26. Weihua Z, Ekman J, Almkvist A, Saji S, Wang L, Warner M, et al. Involvement of androgen receptor in 17beta-estradiol-induced cell proliferation in rat uterus. Biol Reprod. 2002;67(2):616-23.