Nuclear medicine and multimodality imaging of pediatric neuroblastoma

Pediatric Radiology

Volumn 43, Issue 4, 2013, Pages 418-427

  Mueller, Wolfgang Peter ^a   Coppenrath, Eva ^a   Pfluger, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Child; Diagnosis; Iodobenzylguanidine; Multimodality imaging; Neuroblastoma; Positron emission tomography; Scintigraphy

Indexed keywords

(3 IODOBENZYL)GUANIDINE; 3 HYDROXYEPHEDRINE; 6 FLUORODOPA F 18; CARBON 11; CATECHOLAMINE; FLUORODEOXYGLUCOSE F 18; IODINE 123; IODINE 131; NORADRENALIN; SOMATOSTATIN RECEPTOR;

BONE MARROW BIOPSY; BONE SCINTISCANNING; CATECHOLAMINE URINE LEVEL; CELL MATURATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FOLLOW UP; HUMAN; INDUCTION CHEMOTHERAPY; NEUROBLASTOMA; NEUROENDOCRINE TUMOR; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MEDICINE; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SCINTIGRAPHY; SCORING SYSTEM; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR CELL;

AUTONOMIC NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMAGE ENHANCEMENT; INFANT; INFANT, NEWBORN; MALE; NEUROBLASTOMA; NUCLEAR MEDICINE; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; SUBTRACTION TECHNIQUE;

EID: 84876282962     PISSN: 03010449     EISSN: 14321998     Source Type: Journal    
DOI: 10.1007/s00247-012-2512-1     Document Type: Review

References (80)

1. Belgaumi AF, Kauffman WM, Jenkins JJ et al (1997) Blindness in children with neuroblastoma. Cancer 80:1997-2004
2. Kropp J, Hofmann M, Bihl H (1997) Comparison of MIBG and pentetreotide scintigraphy in children with neuroblastoma. Is the expression of somatostatin receptors a prognostic factor? Anticancer Res 17:1583-1588
3. Schmidt M, Simon T, Hero B et al (2008) The prognostic impact of functional imaging with (123)I-mIBG in patients with stage 4 neuroblastoma >1 year of age on a high-risk treatment protocol: results of the German Neuroblastoma Trial NB97. Eur J Cancer 44:1552-1558
4. Taggart D, Dubois S, Matthay KK (2008) Radiolabeled metaiodobenzylguanidine for imaging and therapy of neuroblastoma. Q J Nucl Med Mol Imaging 52:403-418
5. Custodio CM, Semelka RC, Balci NC et al (1999) Adrenal neuroblastoma in an adult with tumor thrombus in the inferior vena cava. J Magn Reson Imaging 9:621-623
6. DuBois SG, Matthay KK (2008) Radiolabeled metaiodobenzylguanidine for the treatment of neuroblastoma. Nucl Med Biol 35(Suppl 1):S35-48
7. Boubaker A, Bischof Delaloye A (2008) MIBG scintigraphy for the diagnosis and follow-up of children with neuroblastoma. Q J Nucl Med Mol Imaging 52:388-402
8. Hugosson C, Nyman R, Jorulf H et al (1999) Imaging of abdominal neuroblastoma in children. Acta Radiol 40:534-542
9. Sofka CM, Semelka RC, Kelekis NL et al (1999) Magnetic resonance imaging of neuroblastoma using current techniques. Magn Reson Imaging 17:193-198
10. Taggart DR, Han MM, Quach A et al (2009) Comparison of iodine-123 metaiodobenzylguanidine (MIBG) scan and [18F]fluorodeoxyglucose positron emission tomography to evaluate response after iodine-131 MIBG therapy for relapsed neuroblastoma. J Clin Oncol 27:5343-5349
11. Sharp SE, Shulkin BL, Gelfand MJ et al (2009) 123I-MIBG scintigraphy and FDG PET in neuroblastoma. J Nucl Med 50:1237-1243
12. Mc Dowell H, Losty P, Barnes N et al (2009) Utility of FDG-PET/CT in the follow-up of neuroblastoma which became MIBG-negative. Pediatr Blood Cancer 52:552
13. Kleis M, Daldrup-Link H, Matthay K et al (2009) Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging 36:23-36
14. Shore RM (2008) Positron emission tomography/computed tomography (PET/CT) in children. Pediatr Ann 37:404-412
15. Rozovsky K, Koplewitz BZ, Krausz Y et al (2008) Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma. Am J Roentgenol 190:1085-1090
16. Murphy JJ, Tawfeeq M, Chang B et al (2008) Early experience with PET/CT scan in the evaluation of pediatric abdominal neoplasms. J Pediatr Surg 43:2186-2192
17. Colavolpe C, Guedj E, Cammilleri S et al (2008) Utility of FDG-PET/CT in the follow-up of neuroblastoma which became MIBG-negative. Pediatr Blood Cancer 51:828-831
18. Roca I, Simo M, Sabado C et al (2007) PET/CT in paediatrics: it is time to increase its use! Eur J Nucl Med Mol Imaging 34:628-629
19. Franzius C, Riemann B, Vormoor J et al (2005) Metastatic neuroblastoma demonstrated by whole-body PET-CT using 11C-HED. Nuklearmedizin 44:N4-5
20. Valk TW, Frager MS, Gross MD et al (1981) Spectrum of pheochromocytoma in multiple endocrine neoplasia. A scintigraphic portrayal using 131I-metaiodobenzylguanidine. Ann Intern Med 94:762-767
21. Wieland DM, Brown LE, Tobes MC et al (1981) Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzylguanidine: concise communication. J Nucl Med 22:358-364
22. Sisson JC, Wieland DM (1986) Radiolabeled meta-iodobenzylguanidine: pharmacology and clinical studies. Am J Physiol Imaging 1:96-103
23. Guilloteau D, Chalon S, Baulieu JL et al (1988) Comparison of MIBG and monoamines uptake mechanisms: pharmacological animal and blood platelets studies. Eur J Nucl Med 14:341-344
24. Claudiani F, Stimamiglio P, Bertolazzi L et al (1995) Radioiodinated meta-iodobenzylguanidine in the diagnosis of childhood neuroblastoma. Q J Nucl Med 39:21-24
25. Rufini V, Calcagni ML, Baum RP (2006) Imaging of neuroendocrine tumors. Semin Nucl Med 36:228-247
26. Howman-Giles R, Shaw PJ, Uren RF et al (2007) Neuroblastoma and other neuroendocrine tumors. Semin Nucl Med 37:286-302
27. Shulkin BL, Shapiro B, Francis IR et al (1986) Primary extra-adrenal pheochromocytoma: positive I-123 MIBG imaging with negative I-131 MIBG imaging. Clin Nucl Med 11:851-854
28. Biasotti S, Garaventa A, Villavecchia GP et al (2000) False-negative metaiodobenzylguanidine scintigraphy at diagnosis of neuroblastoma. Med Pediatr Oncol 35:153-155
29. Troncone L, Rufini V, Montemaggi P et al (1990) The diagnostic and therapeutic utility of radioiodinated metaiodobenzylguanidine (MIBG). 5 years of experience. Eur J Nucl Med 16:325-335
30. Parisi MT, Greene MK, Dykes TM et al (1992) Efficacy of metaiodobenzylguanidine as a scintigraphic agent for the detection of neuroblastoma. Invest Radiol 27:768-773
31. Gelfand MJ (1993) Meta-iodobenzylguanidine in children. Semin Nucl Med 23:231-242
32. Hadj-Djilani NL, Lebtahi NE, Delaloye AB et al (1995) Diagnosis and follow-up of neuroblastoma by means of iodine-123 metaiodobenzylguanidine scintigraphy and bone scan, and the influence of histology. Eur J Nucl Med 22:322-329
33. Khafagi FA, Shapiro B, Fig LM et al (1989) Labetalol reduces iodine-131 MIBG uptake by pheochromocytoma and normal tissues. J Nucl Med 30:481-489
34. Solanki KK, Bomanji J, Moyes J et al (1992) A pharmacological guide to medicines which interfere with the biodistribution of radiolabelled meta-iodobenzylguanidine (MIBG). Nucl Med Commun 13:513-521
35. Gordon I, Peters AM, Gutman A et al (1990) Skeletal assessment in neuroblastoma - the pitfalls of iodine-123-MIBG scans. J Nucl Med 31:129-134
36. Pfluger T, Schmied C, Porn U et al (2003) Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. Am J Roentgenol 181:1115-1124
37. Geatti O, Shapiro B, Shulkin B et al (1988) Gastrointestinal iodine-131-meta-iodobenzylguanidine activity. Am J Physiol Imaging 3:188-191
38. Granata C, Carlini C, Conte M et al (2001) False positive MIBG scan due to accessory spleen. Med Pediatr Oncol 37:138-139
39. McGarvey CK, Applegate K, Lee ND et al (2006) False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus syndrome treated with adrenocorticotropic hormone (acth). J Child Neurol 21:606-610
40. Moralidis E, Arsos G, Papakonstantinou E et al (2008) 123I-Metaiodobenzylguanidine accumulation in a urinoma and cortex of an obstructed kidney after surgical resection of an abdominal neuroblastoma. Pediatr Radiol 38:118-121
41. Bahar RH, Mahmoud S, Ibrahim A et al (1988) A false positive I-131 MIBG due to dilated renal pelvis: a case report. Clin Nucl Med 13:900-902
42. Bonnin F, Lumbroso J, Tenenbaum F et al (1994) Refining interpretation of MIBG scans in children. J Nucl Med 35:803-810
43. Matthay KK, Edeline V, Lumbroso J et al (2003) Correlation of early metastatic response by 123I-metaiodobenzylguanidine scintigraphy with overall response and event-free survival in stage IV neuroblastoma. J Clin Oncol 21:2486-2491
44. Matthay KK, Shulkin B, Ladenstein R et al (2010) Criteria for evaluation of disease extent by (123)I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force. Br J Cancer 102:1319-1326
45. Shulkin BL, Shapiro B, Hutchinson RJ (1992) Iodine-131- metaiodobenzylguanidine and bone scintigraphy for the detection of neuroblastoma. J Nucl Med 33:1735-1740
46. Daldrup-Link HE, Franzius C, Link TM et al (2001) Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol 177:229-236
47. Mentzel HJ, Kentouche K, Sauner D et al (2004) Comparison of whole-body STIR-MRI and 99mTc-methylene-diphosphonate scintigraphy in children with suspected multifocal bone lesions. Eur Radiol 14:2297-2302
48. Goo HW, Choi SH, Ghim T et al (2005) Whole-body MRI of paediatric malignant tumours: comparison with conventional oncological imaging methods. Pediatr Radiol 35:766-773
49. Lebtahi N, Gudinchet F, Nenadov-Beck M et al (1997) Evaluating bone marrow metastasis of neuroblastoma with iodine-123-MIBG scintigraphy and MRI. J Nucl Med 38:1389-1392
50. Kushner BH, Yeung HW, Larson SM et al (2001) Extending positron emission tomography scan utility to high-risk neuroblastoma: fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients. J Clin Oncol 19:3397-3405
51. Shulkin BL, Hutchinson RJ, Castle VP et al (1996) Neuroblastoma: positron emission tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose compared with metaiodobenzylguanidine scintigraphy. Radiology 199:743-750
52. 18F-FDG PET in paediatric neuroblastoma. Eur J Nucl Med Mol Imaging 38:1648-1658
53. Rosenspire KC, Haka MS, Van Dort ME et al (1990) Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med 31:1328-1334
54. Shulkin BL, Wieland DM, Baro ME et al (1996) PET hydroxyephedrine imaging of neuroblastoma. J Nucl Med 37:16-21
55. Schwaiger M, Hutchins GD, Kalff V et al (1991) Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography. J Clin Invest 87:1681-1690
56. Schwaiger M, Kalff V, Rosenspire K et al (1990) Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation 82:457-464
57. Shulkin BL, Wieland DM, Schwaiger M et al (1992) PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med 33:1125-1131
58. Franzius C, Hermann K, Weckesser M et al (2006) Whole-body PET/CT with 11C-meta-hydroxyephedrine in tumors of the sympathetic nervous system: feasibility study and comparison with 123I-MIBG SPECT/CT. J Nucl Med 47:1635-1642
59. Becherer A, Szabo M, Karanikas G et al (2004) Imaging of advanced neuroendocrine tumors with (18)F-FDOPA PET. J Nucl Med 45:1161-1167
60. Hoegerle S, Nitzsche E, Altehoefer C et al (2002) Pheochromocytomas: detection with 18F DOPA whole body PET - initial results. Radiology 222:507-512
61. Mamede M, Carrasquillo JA, Chen CC et al (2006) Discordant localization of 2-[18F]-fluoro-2-deoxy-D-glucose in 6-[18F]-fluorodopamine- and [(123)I]-metaiodobenzylguanidine-negative metastatic pheochromocytoma sites. Nucl Med Commun 27:31-36
62. Piccardo A, Lopci E, Conte M et al (2012) Comparison of 18F-dopa PET/CT and 123I-MIBG scintigraphy in stage 3 and 4 neuroblastoma: a pilot study. Eur J Nucl Med Mol Imaging 39:57-71
63. O'Dorisio MS, Chen F, O'Dorisio TM et al (1994) Characterization of somatostatin receptors on human neuroblastoma tumors. Cell Growth Differ 5:1-8
64. Albers AR, O'Dorisio MS, Balster DA et al (2000) Somatostatin receptor gene expression in neuroblastoma. Regul Pept 88:61-73
65. Georgantzi K, Tsolakis AV, Stridsberg M et al (2011) Differentiated expression of somatostatin receptor subtypes in experimental models and clinical neuroblastoma. Pediatr Blood Cancer 56:584-589
66. Gains JE, Bomanji JB, Fersht NL et al (2011) 177Lu-DOTATATE molecular radiotherapy for childhood neuroblastoma. J Nucl Med 52:1041-1047
67. Muller MF, Krestin GP, Willi UV (1993) Abdominal tumors in children. A comparison between magnetic resonance tomography (MRT) and ultrasonography (US). Rofo 158:9-14
68. Daldrup HE, Link TM, Wortler K et al (1998) MR imaging of thoracic tumors in pediatric patients. Am J Roentgenol 170:1639-1644
69. Kaste SC (2004) Issues specific to implementing PET-CT for pediatric oncology: what we have learned along the way. Pediatr Radiol 34:205-213
70. Bar-Sever Z, Keidar Z, Ben-Barak A et al (2007) The incremental value of FDG PET/CT in paediatric malignancies. Eur J Nucl Med Mol Imaging 34:630-637
71. Olson PN, Everson LI, Griffiths HJ (1994) Staging of musculoskeletal tumors. Radiol Clin N Am 32:151-162
72. Silberstein EB, Saenger EL, Tofe AJ et al (1973) Imaging of bone metastases with 99m Tc-Sn-EHDP (diphosphonate), 18F, and skeletal radiography. A comparison of sensitivity. Radiology 107:551-555
73. Hahn K, Charron M, Shulkin BL (2003) Role of MR imaging and iodine 123 MIBG scintigraphy in staging of pediatric neuroblastoma. Radiology 227:908, author reply 908-909
74. Shah Syed GM, Naseer H, Usmani GN et al (2004) Role of iodine-131 MIBG scanning in the management of paediatric patients with neuroblastoma. Med Princ Pract 13:196-200
75. Moon L, McHugh K (2005) Advances in paediatric tumour imaging. Arch Dis Child 90:608-611
76. Nanni C, Rubello D, Castellucci P et al (2006) FDG PET/CT fusion imaging in paediatric solid extracranial tumours. Biomed Pharmacother 60:593-606
77. Yeung HW, Schoder H, Smith A et al (2005) Clinical value of combined positron emission tomography/computed tomography imaging in the interpretation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography studies in cancer patients. Mol Imaging Biol 7:229-235
78. Franzius C, Daldrup-Link HE, Sciuk J et al (2001) FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT. Ann Oncol 12:479-486
79. Volker T, Denecke T, Steffen I et al (2007) Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial. J Clin Oncol 25:5435-5441
80. Gerth HU, Juergens KU, Dirksen U et al (2007) Significant benefit of multimodal imaging: PET/CT compared with PET alone in staging and follow-up of patients with Ewing tumors. J Nucl Med 48:1932-1939