Phosphodiesterase-8A binds to and regulates Raf-1 kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 16, 2013, Pages

  Brown, Kim M ^a   Day, Jon P ^a   Huston, Elaine ^a   Zimmermann, Bastian ^b   Hampel, Kornelia ^b   Christian, Frank ^a   Romano, David ^c   Terhzaz, Selim ^a   Lee, Louisa C Y ^a   Willis, Miranda J ^a   Morton, David B ^d   Beavo, Joseph A ^e   Shimizu Albergine, Masami ^e   Davies, Shireen A ^a   Kolch, Walter ^c   Houslay, Miles D ^f   Baillie, George S ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Biaffin GmbH and CoKG   (Germany)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 8A; RAF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL STRESS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSGENIC MOUSE;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ANIMALS; BLOTTING, WESTERN; DNA PRIMERS; DROSOPHILA MELANOGASTER; GENE DELETION; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MAP KINASE SIGNALING SYSTEM; MASS SPECTROMETRY; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; SURFACE PLASMON RESONANCE;

DROSOPHILA MELANOGASTER; MURINAE; MUS;

EID: 84876277103     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303004110     Document Type: Article

References (49)

1. Yoon S, Seger R (2006) The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors 24(1):21-44.
2. Kubicek M, et al. (2002) Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J Biol Chem 277(10):7913-7919.
3. Jaumot M, Hancock JF (2001) Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20(30):3949-3958.
4. Dumaz N, Marais R (2003) Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem 278(32):29819-29823.
5. Dhillon AS, et al. (2002) Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol Cell Biol 22(10):3237-3246.
6. Sutherland EW, Robison GA (1966) The role of cyclic-3′, 5′-AMP in responses to catecholamines and other hormones. Pharmacol Rev 18(1):145-161.
7. Walsh DA, et al. (1972) Cyclic AMP-dependent protein kinases from skeletal muscle and liver. Adv Cyclic Nucleotide Res 1:33-45.
8. Cook SJ, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262(5136):1069-1072.
9. Burgering BM, Pronk GJ, van Weeren PC, Chardin P, Bos JL (1993) cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 12(11):4211-4220.
10. Häfner S, et al. (1994) Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol 14(10):6696-6703.
11. Sevetson BR, Kong X, Lawrence JC, Jr. (1993) Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc Natl Acad Sci USA 90(21):10305-10309.
12. Graves LM, et al. (1993) Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 90(21):10300-10304.
13. Wu J, et al. (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′, 5′-monophosphate. Science 262(5136):1065-1069.
14. Matallanas D, et al. (2011) Raf family kinases: Old dogs have learned new tricks. Genes Cancer 2(3):232-260.
15. Gerits N, Kostenko S, Shiryaev A, Johannessen M, Moens U (2008) Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cell Signal 20(9):1592-1607.
16. Houslay MD, Kolch W (2000) Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol Pharmacol 58(4): 659-668.
17. Conti M, Beavo J (2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annu Rev Biochem 76:481-511.
18. Houslay MD (2010) Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem Sci 35(2):91-100.
19. Baillie GS (2009) Compartmentalized signalling: Spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS J 276(7):1790-1799.
20. Zaccolo M (2011) Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol 11(6):649-655.
21. Wang H, et al. (2008) Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry 47(48):12760-12768.
22. Vasta V, Shimizu-Albergine M, Beavo JA (2006) Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc Natl Acad Sci USA 103(52):19925-19930.
23. Vang AG, et al. (2010) PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS ONE 5(8):e12011.
24. Dong H, Osmanova V, Epstein PM, Brocke S (2006) Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Biochem Biophys Res Commun 345(2): 713-719.
25. Patrucco E, Albergine MS, Santana LF, Beavo JA (2010) Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. J Mol Cell Cardiol 49(2):330-333.
26. Soderling SH, Bayuga SJ, Beavo JA (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci USA 95(15):8991-8996.
27. McCahill A, et al. (2005) In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region. Cell Signal 17(9):1158-1173.
28. Baillie GS, et al. (2007) Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N-and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J 404(1):71-80.
29. Meng D, et al. (2009) MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. J Biol Chem 284(17):11425-11435.
30. Anthony DF, et al. (2011) ß-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol 31(5):1066-1075.
31. Bjørgo E, et al. (2010) Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol 30(7):1660-1672.
32. Perino A, et al. (2011) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110y. Mol Cell 42(1):84-95.
33. Smith KJ, et al. (2007) 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. Cell Signal 19(12):2612-2624.
34. Rampersad SN, et al. (2010) Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. J Biol Chem 285(44):33614-33622.
35. Friedman AA, et al. (2011) Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal 4(196):rs10.
36. Atienza JM, et al. (2006) Dynamic and label-free cell-based assays using the real-time cell electronic sensing system. Assay Drug Dev Technol 4(5):597-607.
37. Starsíchová A, et al. (2009) Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-ß1. Biol Proced Online 11:316-324.
38. Ikeyama S, Kokkonen G, Shack S, Wang XT, Holbrook NJ (2002) Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J 16(1):114-116.
39. Wu P, Wang P (2004) Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins. Proc Natl Acad Sci USA 101(51): 17634-17639.
40. Zebisch A, Troppmair J (2006) Back to the roots: The remarkable RAF oncogene story. Cell Mol Life Sci 63(11):1314-1330.
41. Davies H, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417(6892):949-954.
42. Flaherty KT, et al. (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363(9):809-819.
43. Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N (2010) RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464(7287):427-430.
44. Heidorn SJ, et al. (2010) Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140(2):209-221.
45. Rushworth LK, Hindley AD, O'Neill E, Kolch W (2006) Regulation and role of Raf-1/B-Raf heterodimerization. Mol Cell Biol 26(6):2262-2272.
46. Dumaz N, et al. (2006) In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 66(19): 9483-9491.
47. Marquette A, André J, Bagot M, Bensussan A, Dumaz N (2011) ERK and PDE4 cooperate to induce RAF isoform switching in melanoma. Nat Struct Mol Biol 18(5): 584-591.
48. Kramer A, Schneider-Mergener J (1998) Synthesis and screening of peptide libraries on continuous cellulose membrane supports. Methods in Molecular Biology; Combinatorial peptide library protocols Methods Mol Biol 87:25-39.
49. Frangioni JV, Neel BG (1993) Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal Biochem 210(1):179-187.