Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells

Experimental and Molecular Medicine

Volumn 45, Issue 2, 2013, Pages

  Park, Sung Nam ^a   Noh, Kyung Tae ^a   Jeong, Young Il ^b   Jung, In Duk ^a   Kang, Hyun Kyu ^a   Cha, Gil Sun ^a   Lee, Su Jung ^a   Seo, Jong Keun ^a   Kang, Dae Hwan ^c   Hwang, Tae Ho ^c   Lee, Eun Kyung ^d   Kwon, Byungsuk ^e   Park, Yeong Min ^a,c  

^a Pusan National University School of Medicine   (South Korea)

^b Korea Centers for Disease Control and Prevention   (South Korea)

^c Pusan National University Yangsan Hospital   (South Korea)

^d Chung Ang University   (South Korea)

^e University of Ulsan   (South Korea)

Author keywords

Adjuvant; Dendritic cells; Rhamnogalacturonan II; Toll like receptor 4; Tumor

Indexed keywords

CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR7; DENDRITIC CELL VACCINE; GAMMA INTERFERON; GINSENG EXTRACT; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; OVALBUMIN; RHAMNOGALACTURONAN II; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; CARRIER PROTEIN; CD14 ANTIGEN; CHEMOKINE RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PECTIN; TICAM 1 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GINSENG; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOMA; LYMPHOMA CELL; MOUSE; NONHUMAN; PHENOTYPE; PLANT LEAF; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN TRANSPORT; ANIMAL CELL; BONE MARROW DERIVED DENDRITIC CELL; CANCER IMMUNIZATION;

ACUTE-PHASE PROTEINS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, CD14; BONE MARROW CELLS; CARRIER PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CYTOKINES; DENDRITIC CELLS; ENZYME ACTIVATION; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASMS; NF-KAPPA B; PECTINS; PHENOTYPE; PROTEIN TRANSPORT; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TOLL-LIKE RECEPTOR 4;

EID: 84876264251     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.14     Document Type: Article

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