Epithelial cell adhesion molecule (EpCAM) overexpression is correlated with malignant potentials of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas

Biomedical Research (Japan)

Volumn 34, Issue 2, 2013, Pages 87-95

  Yonaiyama, Shinnosuke ^a   Toyoki, Yoshikazu ^a   Morohashi, Satoko ^a   Sakuraba, Shingo ^a   Yoshizawa, Tadashi ^a   Suzuki, Takahiro ^a   Wu, Yunyan ^a   Kijima, Hiroshi ^a   Hakamada, Kenichi ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CLINICAL FEATURE; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; MAJOR CLINICAL STUDY; MALE; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; UNIVARIATE ANALYSIS;

AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; CELL ADHESION MOLECULES; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUCINS; PANCREATIC NEOPLASMS;

EID: 84876260336     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.34.87     Document Type: Article

References (28)

1. Adsay NV, Fukushima N, Furukawa T, Hruban RH and Klimstra DS (2010) Intraductal neoplasms of the pancreas. In: World Health Organization of Classification of Tumors of the Digestive System 4th Edition (Bosman FT, Carneiro F, Hruban RH and Theise ND, eds), pp304-313, International Agency for Research on Cancer, Lyon.
2. Baeuerle PA and Gires O (2007) EpCAM (CD326) finding its role in cancer. Br J Cancer 96, 417-423.
3. Chadwick B, Willmore-Payne C, Tripp S, Layfield LJ, Hirschowitz S and Holden J (2009) Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas. Appl Immunohistochem Mol Morphol 17, 31-39.
4. Fong D, Steurer M, Obrist P, Barbieri V, Margreiter R, Amberger A, Laimer K, Gastl G, Tzankov A and Spizzo G (2008) Ep-CAM expression in pancreatic and ampullary carcinomas: frequency and prognostic relevance. J Clin Pathol 61, 31-35.
5. Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S and Shimizu M (2011) Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut 60, 509-516.
6. Furukawa T, Kloppel G, Volkan Adsay N, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, Luttges J, Offerhaus GJ, Shimizu M, Sunamura M, Suriawinata A, Takaori K and Yonezawa S (2005) Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447, 794-799.
7. Gastl G, Spizzo G, Obrist P, Dunser M and Mikuz G (2000) Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 356, 1981-1982.
8. Hirono S, Tani M, Kawai M, Ina S, Nishioka R, Miyazawa M, Fujita Y, Uchiyama K and Yamaue H (2009) Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors. Arch Surg 144, 345-350.
9. Japan Pancreas Society (2009) General Rules for the Study of Pancreatic Cancer, 6th ed., pp21-40, Kanehara, Tokyo.
10. Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, Masamune A, Asakura T and Shimosegawa T (2010) Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas. J Gastroenterol 45, 952-959.
11. Kudo Y, Morohashi S, Takasugi K, Tsutsumi S, Ogasawara H, Hanabata N, Yoshimura T, Sato F, Fukuda S and Kijima H (2011) Histopathological phenotypes of early gastric cancer and its background mucosa. Biomed Res 32, 127-134.
12. Lee JH, Kim KS, Kim TJ, Hong SP, Song SY, Chung JB and Park SW (2011) Immunohistochemical analysis of claudin expression in pancreatic cystic tumors. Oncol Rep 25, 971-978.
13. Litvinov SV, Velders MP, Bakker HA, Fleuren GJ and Warnaar SO (1994) Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125, 437-446.
14. Maker AV, Katabi N, Gonen M, DeMatteo RP, D'Angelica MI, Fong Y, Jarnagin WR, Brennan MF and Allen PJ (2011) Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas. Ann Surg Oncol 18, 199-206.
15. Michaels PJ, Brachtel EF, Bounds BC, Brugge WR and Pitman MB (2006) Intraductal papillary mucinous neoplasm of the pancreas: cytologic features predict histologic grade. Cancer 108, 163-173.
16. Munz M, Murr A, Kvesic M, Rau D, Mangold S, Pflanz S, Lumsden J, Volkland J, Fagerberg J, Riethmuller G, Ruttinger D, Kufer P, Baeuerle PA and Raum T (2010) Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies. Cancer Cell Int 10, 44.
17. Ohhashi K, Murakami Y, Maruyama M, Takekoshi T, Hirotoshi O, Ohhashi I, Takagi K and Kato Y (1982) Four cases of mucous secreating pancreatic cancer. Prog Digest Endosc 20, 348-351.
18. Okimura A, Hirano H, Nishigami T, Ueyama S, Tachibana S, Fukuda Y, Yamanegi K, Ohyama H, Terada N and Nakasho K (2009) Immunohistochemical analyses of E-cadherin, betacatenin, CD44s, and CD44v6 expressions, and Ki-67 labeling index in intraductal papillary mucinous neoplasms of the pancreas and associated invasive carcinomas. Med Mol Morphol 42, 222-229.
19. Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ and Gillanders WE (2004) EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64, 5818-5824.
20. Raffel A, Eisenberger CF, Cupisti K, Schott M, Baldus SE, Hoffmann I, Aydin F, Knoefel WT and Stoecklein NH (2010) Increased EpCAM expression in malignant insulinoma: potential clinical implications. Eur J Endocrinol 162, 391-398.
21. Satoh K, Hamada S, Kanno A, Hirota M, Umino J, Ito H, Masamune A, Egawa S, Unno M and Shimosegawa T (2010) Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol 45, 763-770.
22. Shimamoto T, Tani M, Kawai M, Hirono S, Ina S, Miyazawa M, Shimizu A, Uchiyama K, Yokoyama S, Tsutsumi M and Yamaue H (2010) MUC1 is a useful molecular marker for malignant intraductal papillary mucinous neoplasms in pan- creatic juice obtained from endoscopic retrograde pancreatography. Pancreas 39, 879-883.
23. Shin SH, Han DJ, Park KT, Kim YH, Park JB and Kim SC (2010) Validating a simple scoring system to predict malignancy and invasiveness of intraductal papillary mucinous neoplasms of the pancreas. World J Surg 34, 776-783.
24. Spizzo G, Went P, Dirnhofer S, Obrist P, Simon R, Spichtin H, Maurer R, Metzger U, von Castelberg B, Bart R, Stopatschinskaya S, Kochli OR, Haas P, Mross F, Zuber M, Dietrich H, Bischoff S, Mirlacher M, Sauter G and Gastl G (2004) High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast Cancer Res Treat 86, 207-213.
25. Stoecklein NH, Siegmund A, Scheunemann P, Luebke AM, Erbersdobler A, Verde PE, Eisenberger CF, Peiper M, Rehders A, Esch JS, Knoefel WT and Hosch SB (2006) Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker. BMC Cancer 6, 165.
26. Varga M, Obrist P, Schneeberger S, Muhlmann G, Felgel- Farnholz C, Fong D, Zitt M, Brunhuber T, Schafer G, Gastl G and Spizzo G (2004) Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res 10, 3131-3136.
27. Wiesenauer CA, Schmidt CM, Cummings OW, Yiannoutsos CT, Howard TJ, Wiebke EA, Goulet RJ, Jr., McHenry L, Sherman S, Lehman GA, Cramer H and Madura JA (2003) Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms. Arch Surg 138, 610-618.
28. Yonezawa S, Sueyoshi K, Nomoto M, Kitamura H, Nagata K, Arimura Y, Tanaka S, Hollingsworth MA, Siddiki B, Kim YS and Sato E (1997) MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum Pathol 28, 344-352.