Altered balance between IL-17A- and IL-17F-producing Th17 cells in HIV-infected patients

Journal of Acquired Immune Deficiency Syndromes

Volumn 63, Issue 1, 2013, Pages

  Salem, Mohammad ^a,b   Ronit, Andreas ^a,b   Gaardbo, Julie C ^a,b   Lund, Tamara T ^a,b   Ullum, Henrik ^b   Gerstoft, Jan ^a   Nielsen, Susanne D ^a  

^a Department of Infectious Diseases M5121 ^*  (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INTERLEUKIN 17; INTERLEUKIN 17F;

CD4 LYMPHOCYTE COUNT; CELL FUNCTION; CROSS-SECTIONAL STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TH17 CELL; VIRUS REPLICATION;

ADULT; ANTI-HIV AGENTS; CROSS-SECTIONAL STUDIES; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-17; MALE; MIDDLE AGED; PROGNOSIS; TH17 CELLS;

EID: 84876255414     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3182893f96     Document Type: Letter

References (12)

1. Bettelli E, Korn T, Oukka M, et al. Induction and effector functions of T(H)17 cells. Nature. 2008;453:1051-1057.
2. Miossec P, Kolls JK. Targeting IL-17 and T(H)17 cells in chronic inflammation. Nat Rev Drug Discov. 2012;11:763-776.
3. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12: 1365-1371.
4. Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 2008;112: 2826-2835.
5. Prendergast A, Prado JG, Kang YH, et al. HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells. AIDS. 2010;24: 491-502.
6. Ndhlovu LC, Chapman JM, Jha AR, et al. Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. AIDS. 2008;22: 990-992.
7. Maek AN, Buranapraditkun S, Klaewsongkram J, et al. Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection. Viral Immunol. 2007;20:66-75.
8. Brandt L, Benfield T, Mens H, et al. Low level of regulatory T cells and maintenance of balance between regulatory T cells and TH17 cells in HIV-1-infected elite controllers. J Acquir Immune Defic Syndr. 2011; 57:101-108.
9. Hartling HJ, Gaardbo JC, Ronit A, et al. CD4(+) and CD8(+) regulatory T cells (Tregs) are elevated and display an active phenotype in patients with chronic HCV mono-infection and HIV/HCV co-infection. Scand J Immunol. 2012;76:294-305.
10. Cosmi L, De PR, Santarlasci V, et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med. 2008;205:1903-1916.
11. Costa-Rodriguez EV, Rivino L, Geginat J, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007; 8:639-646.
12. Monteiro P, Gosselin A, Wacleche VS, et al. Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin beta7. J Immunol. 2011;186:4618-4630.