Accuracy and preference assessment of prefilled insulin pen versus vial and syringe with diabetes patients, caregivers, and healthcare professionals

Current Medical Research and Opinion

Volumn 29, Issue 5, 2013, Pages 475-481

  Pfützner, Andreas ^a,b   Bailey, Timothy ^c   Campos, Carlos ^d   Kahn, Douglas ^a   Ambers, Ellen ^a   Niemeyer, Marcus ^e   Guerrero, German ^f   Klonoff, David ^g   Nayberg, Irina ^g  

^a ICRD Institute   (United States)

^b IKFE Institute for Clinical Research and Development   (Germany)

^c AMCR Institute Inc   (United States)

^d Institute for Public Health and Education Research   (United States)

^e NOVO NORDISK A S   (Denmark)

^f NOVO NORDISK INC   (United States)

^g Mills Peninsula Health Services   (United States)

Author keywords

Diabetes; Insulin treatment; Patient preference; Pen injection device; Vial and syringe

Indexed keywords

INSULIN;

ADULT; ARTICLE; CAREGIVER; CLINICAL ARTICLE; DEVICE ASSESSMENT QUESTIONNAIRE; DEVICE PREFERENCE QUESTIONNAIRE; DIABETES MELLITUS; DIABETIC PATIENT; DRUG DELIVERY SYSTEM; FEMALE; HEALTH CARE PERSONNEL; HUMAN; MALE; MEDICAL DEVICE; PATIENT COMPLIANCE; PATIENT PERCEPTION QUESTIONNAIRE; PREFILLED INSULIN PEN; QUESTIONNAIRE; SYRINGE;

AGED; CAREGIVERS; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; MALE; MIDDLE AGED; NURSES; PHYSICIANS; SYRINGES;

EID: 84876238637     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2013.775112     Document Type: Article

References (27)

1. Arslanoglu I, Saka N, Bundak R, et al. A comparison of the use of premixed insulins in pen-injectors with conventional patient-mixed insulin treatment in children and adolescents with IDDM. Is there a decreased risk of night hypoglycemia? J Pediatr Endocrinol Metab 2000;13:313-18
2. Bohannon NJ, Ohannesian JP, Burdan AL, et al. Patient and physician satisfaction with the Humulin/Humalog Pen, a new 3.0-mL prefilled pen device for insulin delivery. Clin Ther 2000;22:1049-67
3. Asakura T, Seino H, Nakano R, et al. A comparison of the handling and accuracy of syringe and vial versus prefilled insulin pen (FlexPen). Diabetes Technol Ther 2009;11:657-61
4. Hunt LM, Valenzuela MA, Pugh JA. NIDDM patients' fears and hopes about insulin therapy. The basis for patient reluctance. Diabetes Care 1997;20: 292-8
5. Hamilton JG. Needle phobia: a neglected diagnosis. J Fam Pract 1995;41: 169-73
6. Korytkowski M, Niskanen L, Asakura T. FlexPen: addressing issues of confidence and convenience in insulin delivery. Clin Ther 2005;27(Suppl B): 89-100
7. Pfutzner A. FlexPen for the delivery of insulin: recent developments in accuracy, injection force and patient preference. Exp Opin Med Dev 2009;6:115-23
8. Reimer T, Hohberg C, Pfutzner AH, et al. Instruction time, intuitiveness and patient acceptance of a prefilled and a re-usable insulin delivery device - the NovoMix 30 FlexPen and the HumaPen Luxura TM . Clin Ther 2009;30:2252-62
9. Pfutzner A, Reimer T, Hohberg C, et al. Prefilled insulin device with reduced injection force: patient perception and accuracy. Curr Med Res Opin 2008;24:254-9
10. Asakura T. Comparison of clinically relevant technical attributes of five insulin injection pens. J Diabetes Sci Technol 2011;5:1203-9
11. Lee LJ, Li Q, Reynolds MW, et al. Trend analyses of insulin delivery systems in the United States. J Diabetes Sci Technol 2011;5:1116-23
12. Kesson CM, Bailie BR. Do diabetic patients inject accurate doses of insulin? Diabetes Care 1981;4:333
13. Puxty JA, Hunter DA, Burr WA. Accuracy of insulin injection in elderly patients. Br Med J (Clin Res Ed) 1983;287:1762
14. Niskanen L, Jensen LE, Rastam J, et al. Randomized, multinational, openlabel, 2-period, crossover comparison of biphasic insulin aspart 30 and biphasic insulin lispro 25 and pen devices in adult patients with type 2 diabetes. Clin Therapeut 2004;26:531-40
15. Luijf YM, DeVries JH. Dosing accuracy of insulin pens versus conventional syringes and vials. Diabetes Technol Ther 2010;12(Suppl 1):S73-7
16. Ignaut DA, Schwartz SL, Sarwat S, Murphy HL. Comparative device assessments: Humalog KwikPen compared with vial and syringe and FlexPen. Diabetes Educ 2009;35:789-98
17. Clarke A, Spollett G. Dose accuracy and injection force dynamics of a novel disposable insulin pen. Expert Opin Drug Deliv 2007;4:165-74
18. Asche CV, Shane-McWhorter L, Raparla S. Health economics and compliance of vials/syringes versus pen devices: a review of the evidence. Diabetes Technol Ther 2010;12(Suppl 1):S101-8
19. Lee WC, Balu S, Cobden D, et al. Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims data. Clin Ther 2006;28:1712-25
20. Baser O, Bouchard J, DeLuzio T, et al. Assessment of adherence and healthcare costs of insulin device (FlexPen) versus conventional vial/syringe. Adv Ther 2010;27:94-104
21. Rubin RR, Peyrot M. Factors affecting use of insulin pens by patients with type 2 diabetes. Diabetes Care 2008;31:430-2
22. Pfutzner J, Hellhammer J, Musholt PB, et al. Evaluation of dexterity, in patients with insulin treated type 1 and type 2 diabetes mellitus. J Diabetes Sci Technol 2011;5:158-65
23. Pfutzner A, Musholt PB, Schipper C, et al. Self-assessment and objective determination of dexterity and cognitive function in patients with type 1 and type 2 diabetes mellitus. Curr Med Res Opin 2012;28:15-21
24. Pfutzner A, Schipper C, Niemeyer M, et al. Comparison of patients' preference for two insulin injection pen devices in relation to patient dexterity skills. J Diabetes Sci Technol 2012;6:910-16
25. Schipper C, Musholt PB, Niemeyer M, et al. Patient device assessment evaluation for FlexTouch vs. InnoLet in a mixed cohort of insulin-treated patients with type 1 or type 2 diabetes mellitus. Curr Med Res Opin 2012;28:1297-303
26. Lee WC, Balu S, Cobden D, et al. Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third party managed care claims data. Clin Ther 2006;28:1712-25
27. Davis EM, Bebee A, Crawford L, et al. Nurse satisfaction using insulin pens in hospitalized patients. Diabetes Educator 2009;35:799-809